Heme metabolism nonhuman 28 animal experiment 24 article 24 controlled study 24 mouse 24 5 aminolevulinate synthase 22 Animals 22 enzyme activity 22 male 22 animal model 20 animal tissue 20 Mice 18 heme oxygenase 18 5-Aminolevulinate Synthetase 16 Oxidative Stress 16 heme 16 Heme 14 Liver 14 Male 14 oxidative stress 14 priority journal 14 Animalia 12 glutathione 12 isoflurane 12 Heme Oxygenase (Decyclizing) 10 Isoflurane 10 Oxidative stress 10 cytochrome P450 2E1 10 drug metabolism 10