Effect of in vivo administration of 5α reductase inhibitors on epididymal function

Progesterone, epitestosterone (4-androstene-17 α-o1-3-one, EpiT) and 4- androstene-3-one-17β-carboxylic acid (COOH), three known in vitro inhibitors of 5α reductase, were injected daily for 30 days into male rats to study their effect on some parameters of epididymal function. Progesterone at a dose...

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Autores principales:	De Larminat, M.A., Blaquier, J.A.
Formato:	JOUR
Materias:	epitestosterone progesterone radioisotope steroid reductase 3 oxo 4 etienic acid 5alpha androstane 3alpha,17beta diol c 14 androstanolone c 14 animal experiment dose response drug response endocrine system enzyme inhibition epididymis fertility liver male genital system prostate rat seminal vesicle spermatozoon count testis testosterone h 3 Animal Body Weight Epididymis Epitestosterone Female Fertility Genitalia, Male Male Organ Weight Oxidoreductases Pregnancy Progesterone Rats Rats, Inbred Strains Sperm Count Support, Non-U.S. Gov't Testosterone Testosterone 5-alpha-Reductase
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_NIS18557_v29_n1_p1_DeLarminat
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_NIS18557_v29_n1_p1_DeLarminat
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spelling	todo:paper_NIS18557_v29_n1_p1_DeLarminat2023-10-03T16:46:04Z Effect of in vivo administration of 5α reductase inhibitors on epididymal function De Larminat, M.A. Blaquier, J.A. epitestosterone progesterone radioisotope steroid reductase 3 oxo 4 etienic acid 5alpha androstane 3alpha,17beta diol c 14 androstanolone c 14 animal experiment dose response drug response endocrine system enzyme inhibition epididymis fertility liver male genital system prostate rat seminal vesicle spermatozoon count testis testosterone h 3 Animal Body Weight Epididymis Epitestosterone Female Fertility Genitalia, Male Male Organ Weight Oxidoreductases Pregnancy Progesterone Rats Rats, Inbred Strains Sperm Count Support, Non-U.S. Gov't Testosterone Testosterone 5-alpha-Reductase Progesterone, epitestosterone (4-androstene-17 α-o1-3-one, EpiT) and 4- androstene-3-one-17β-carboxylic acid (COOH), three known in vitro inhibitors of 5α reductase, were injected daily for 30 days into male rats to study their effect on some parameters of epididymal function. Progesterone at a dose of 750 and 2000 μg/day decreased fertility by 59% and 50%, respectively. EpiT at a dose of 1 500 μg/day decreased fertility by 74%. These treatments did not change the sperm counts in the cauda epididynis. epididymis. with COOH did not decrease fertility. Progesterone at 750 and 2 000 μg/day and EpiT at 750 μg/day decreased the weight of the epididymis, prostate and seminal vesicles. None of the compounds tested produced variations in body weight or in the weight of liver and testis. The 5α reductase activity of epididymis, testis and liver was diminished by progesterone treatment, while EpiT decreased only that of testis and liver. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_NIS18557_v29_n1_p1_DeLarminat
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	epitestosterone progesterone radioisotope steroid reductase 3 oxo 4 etienic acid 5alpha androstane 3alpha,17beta diol c 14 androstanolone c 14 animal experiment dose response drug response endocrine system enzyme inhibition epididymis fertility liver male genital system prostate rat seminal vesicle spermatozoon count testis testosterone h 3 Animal Body Weight Epididymis Epitestosterone Female Fertility Genitalia, Male Male Organ Weight Oxidoreductases Pregnancy Progesterone Rats Rats, Inbred Strains Sperm Count Support, Non-U.S. Gov't Testosterone Testosterone 5-alpha-Reductase
spellingShingle	epitestosterone progesterone radioisotope steroid reductase 3 oxo 4 etienic acid 5alpha androstane 3alpha,17beta diol c 14 androstanolone c 14 animal experiment dose response drug response endocrine system enzyme inhibition epididymis fertility liver male genital system prostate rat seminal vesicle spermatozoon count testis testosterone h 3 Animal Body Weight Epididymis Epitestosterone Female Fertility Genitalia, Male Male Organ Weight Oxidoreductases Pregnancy Progesterone Rats Rats, Inbred Strains Sperm Count Support, Non-U.S. Gov't Testosterone Testosterone 5-alpha-Reductase De Larminat, M.A. Blaquier, J.A. Effect of in vivo administration of 5α reductase inhibitors on epididymal function
topic_facet	epitestosterone progesterone radioisotope steroid reductase 3 oxo 4 etienic acid 5alpha androstane 3alpha,17beta diol c 14 androstanolone c 14 animal experiment dose response drug response endocrine system enzyme inhibition epididymis fertility liver male genital system prostate rat seminal vesicle spermatozoon count testis testosterone h 3 Animal Body Weight Epididymis Epitestosterone Female Fertility Genitalia, Male Male Organ Weight Oxidoreductases Pregnancy Progesterone Rats Rats, Inbred Strains Sperm Count Support, Non-U.S. Gov't Testosterone Testosterone 5-alpha-Reductase
description	Progesterone, epitestosterone (4-androstene-17 α-o1-3-one, EpiT) and 4- androstene-3-one-17β-carboxylic acid (COOH), three known in vitro inhibitors of 5α reductase, were injected daily for 30 days into male rats to study their effect on some parameters of epididymal function. Progesterone at a dose of 750 and 2000 μg/day decreased fertility by 59% and 50%, respectively. EpiT at a dose of 1 500 μg/day decreased fertility by 74%. These treatments did not change the sperm counts in the cauda epididynis. epididymis. with COOH did not decrease fertility. Progesterone at 750 and 2 000 μg/day and EpiT at 750 μg/day decreased the weight of the epididymis, prostate and seminal vesicles. None of the compounds tested produced variations in body weight or in the weight of liver and testis. The 5α reductase activity of epididymis, testis and liver was diminished by progesterone treatment, while EpiT decreased only that of testis and liver.
format	JOUR
author	De Larminat, M.A. Blaquier, J.A.
author_facet	De Larminat, M.A. Blaquier, J.A.
author_sort	De Larminat, M.A.
title	Effect of in vivo administration of 5α reductase inhibitors on epididymal function
title_short	Effect of in vivo administration of 5α reductase inhibitors on epididymal function
title_full	Effect of in vivo administration of 5α reductase inhibitors on epididymal function
title_fullStr	Effect of in vivo administration of 5α reductase inhibitors on epididymal function
title_full_unstemmed	Effect of in vivo administration of 5α reductase inhibitors on epididymal function
title_sort	effect of in vivo administration of 5α reductase inhibitors on epididymal function
url	http://hdl.handle.net/20.500.12110/paper_NIS18557_v29_n1_p1_DeLarminat
work_keys_str_mv	AT delarminatma effectofinvivoadministrationof5areductaseinhibitorsonepididymalfunction AT blaquierja effectofinvivoadministrationof5areductaseinhibitorsonepididymalfunction
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Effect of in vivo administration of 5α reductase inhibitors on epididymal function

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