Intrahypophyseal immune-endocrine interactions: Endocrine integration of the inflammatory inputs

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Endotoxin (lipopolysaccharide, LPS) of gram-negative bacteria has been recognized for more than 40 years as a modulator of anterior pituitary hormone production. The action of LPS was thought to be predominantly mediated through LPS-stimulated immune cell-derived cytokines, and is part of the concep...

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Autores principales: Renner, U., Sapochnik, M., Lucia, K., Stalla, G.K., Arzt, E.
Formato: CHAP
Materias:
lipopolysaccharide
animal
human
hypophysis
immunology
innate immunity
physiology
Animals
Humans
Immunity, Innate
Lipopolysaccharides
Pituitary Gland
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_97833180_v48_n_p37_Renner
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_97833180_v48_n_p37_Renner
record_format dspace
spelling todo:paper_97833180_v48_n_p37_Renner2023-10-03T16:44:48Z Intrahypophyseal immune-endocrine interactions: Endocrine integration of the inflammatory inputs Renner, U. Sapochnik, M. Lucia, K. Stalla, G.K. Arzt, E. lipopolysaccharide animal human hypophysis immunology innate immunity physiology Animals Humans Immunity, Innate Lipopolysaccharides Pituitary Gland Endotoxin (lipopolysaccharide, LPS) of gram-negative bacteria has been recognized for more than 40 years as a modulator of anterior pituitary hormone production. The action of LPS was thought to be predominantly mediated through LPS-stimulated immune cell-derived cytokines, and is part of the concept of immune-endocrine crosstalk, which regulates bidirectional adaptive processes between the endocrine and immune systems during inflammatory or infectious processes. With the detection of innate immune system components in the normal and tumoral pituitary, including the Toll-like receptor 4, the target of LPS, it has become evident that LPS can directly modify the physiology and pathophysiology of the anterior pituitary. LPS-induced intrapituitary mechanisms involve the stimulation of intrapituitary cytokines, and also directly act on hormone synthesis, growth, and apoptosis of endocrine cells. This review focuses on the effects of LPS on pituitary physiology, its interaction with pro- and anti-inflammatory factors, and the molecular mechanisms involved in these processes. © 2017 S. Karger AG, Basel. All rights reserved. CHAP info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_97833180_v48_n_p37_Renner
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic lipopolysaccharide
animal
human
hypophysis
immunology
innate immunity
physiology
Animals
Humans
Immunity, Innate
Lipopolysaccharides
Pituitary Gland
spellingShingle lipopolysaccharide
animal
human
hypophysis
immunology
innate immunity
physiology
Animals
Humans
Immunity, Innate
Lipopolysaccharides
Pituitary Gland
Renner, U.
Sapochnik, M.
Lucia, K.
Stalla, G.K.
Arzt, E.
Intrahypophyseal immune-endocrine interactions: Endocrine integration of the inflammatory inputs
topic_facet lipopolysaccharide
animal
human
hypophysis
immunology
innate immunity
physiology
Animals
Humans
Immunity, Innate
Lipopolysaccharides
Pituitary Gland
description Endotoxin (lipopolysaccharide, LPS) of gram-negative bacteria has been recognized for more than 40 years as a modulator of anterior pituitary hormone production. The action of LPS was thought to be predominantly mediated through LPS-stimulated immune cell-derived cytokines, and is part of the concept of immune-endocrine crosstalk, which regulates bidirectional adaptive processes between the endocrine and immune systems during inflammatory or infectious processes. With the detection of innate immune system components in the normal and tumoral pituitary, including the Toll-like receptor 4, the target of LPS, it has become evident that LPS can directly modify the physiology and pathophysiology of the anterior pituitary. LPS-induced intrapituitary mechanisms involve the stimulation of intrapituitary cytokines, and also directly act on hormone synthesis, growth, and apoptosis of endocrine cells. This review focuses on the effects of LPS on pituitary physiology, its interaction with pro- and anti-inflammatory factors, and the molecular mechanisms involved in these processes. © 2017 S. Karger AG, Basel. All rights reserved.
format CHAP
author Renner, U.
Sapochnik, M.
Lucia, K.
Stalla, G.K.
Arzt, E.
author_facet Renner, U.
Sapochnik, M.
Lucia, K.
Stalla, G.K.
Arzt, E.
author_sort Renner, U.
title Intrahypophyseal immune-endocrine interactions: Endocrine integration of the inflammatory inputs
title_short Intrahypophyseal immune-endocrine interactions: Endocrine integration of the inflammatory inputs
title_full Intrahypophyseal immune-endocrine interactions: Endocrine integration of the inflammatory inputs
title_fullStr Intrahypophyseal immune-endocrine interactions: Endocrine integration of the inflammatory inputs
title_full_unstemmed Intrahypophyseal immune-endocrine interactions: Endocrine integration of the inflammatory inputs
title_sort intrahypophyseal immune-endocrine interactions: endocrine integration of the inflammatory inputs
url http://hdl.handle.net/20.500.12110/paper_97833180_v48_n_p37_Renner
work_keys_str_mv AT renneru intrahypophysealimmuneendocrineinteractionsendocrineintegrationoftheinflammatoryinputs
AT sapochnikm intrahypophysealimmuneendocrineinteractionsendocrineintegrationoftheinflammatoryinputs
AT luciak intrahypophysealimmuneendocrineinteractionsendocrineintegrationoftheinflammatoryinputs
AT stallagk intrahypophysealimmuneendocrineinteractionsendocrineintegrationoftheinflammatoryinputs
AT arzte intrahypophysealimmuneendocrineinteractionsendocrineintegrationoftheinflammatoryinputs
_version_ 1807315765091631104

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