Galactofuranosyl-containing glycans: Occurrence, synthesis and biochemistry

Galactofuranosyl units (Galf), mainly in the β-configuration, are constituents of infectious microorganisms, such as the Mycobacteria, trypanosomatids like Trypanosoma cruzi and Leishmania, and fungi like Aspergillus fumigatus. The metabolic pathways involved in the biosynthesis of the microbial gly...

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Autores principales: Marino, C., Gallo-Rodriguez, C., de Lederkremer, R.M.
Formato: CHAP
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_97816194_v_n_p207_Marino
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_97816194_v_n_p207_Marino2023-10-03T16:44:23Z Galactofuranosyl-containing glycans: Occurrence, synthesis and biochemistry Marino, C. Gallo-Rodriguez, C. de Lederkremer, R.M. Galactofuranosyl units (Galf), mainly in the β-configuration, are constituents of infectious microorganisms, such as the Mycobacteria, trypanosomatids like Trypanosoma cruzi and Leishmania, and fungi like Aspergillus fumigatus. The metabolic pathways involved in the biosynthesis of the microbial glycoconjugates containing Galf are attractive targets for the development of therapeutic agents, because Galf is absent in mammalian cells. The enzymes involved in the biosynthesis of Galf-containing molecules are the UDP-galactopyranosyl mutase, which catalyzes the interconversion of UDP-Galp into UDP-Galf, the donor of Galf units, and the galactofuranosyltransferases, which are responsible for the incorporation of the sugar into the glycoconjugates. In some species, β-D-galactofuranosidases have been identified as responsible for the degradation of the D-Galf containing glycoconjugates. Although the metabolism of β-D-galactofuranosides has been extensively studied, the α-D-Galf biosynthetic and metabolic machinery still remain unclear. The description of the enzymes involved in its metabolism is important, considering that glycoconjugates containing α-D-Galf residues have been also described in several pathogenic microorganisms including bacteria, such as Escherichia coli and Streptococcus pneumoniae, and fungi, such as Paracoccidioides brasiliensis, the causative agent of paracoccidioidomycosis. It is interesting that in the latter Galf is present in both anomeric configurations. Recent methods for the synthesis of galactofuranosides are included in this chapter. © 2012 by Nova Science Publishers, Inc. All rights reserved. CHAP info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_97816194_v_n_p207_Marino
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
description Galactofuranosyl units (Galf), mainly in the β-configuration, are constituents of infectious microorganisms, such as the Mycobacteria, trypanosomatids like Trypanosoma cruzi and Leishmania, and fungi like Aspergillus fumigatus. The metabolic pathways involved in the biosynthesis of the microbial glycoconjugates containing Galf are attractive targets for the development of therapeutic agents, because Galf is absent in mammalian cells. The enzymes involved in the biosynthesis of Galf-containing molecules are the UDP-galactopyranosyl mutase, which catalyzes the interconversion of UDP-Galp into UDP-Galf, the donor of Galf units, and the galactofuranosyltransferases, which are responsible for the incorporation of the sugar into the glycoconjugates. In some species, β-D-galactofuranosidases have been identified as responsible for the degradation of the D-Galf containing glycoconjugates. Although the metabolism of β-D-galactofuranosides has been extensively studied, the α-D-Galf biosynthetic and metabolic machinery still remain unclear. The description of the enzymes involved in its metabolism is important, considering that glycoconjugates containing α-D-Galf residues have been also described in several pathogenic microorganisms including bacteria, such as Escherichia coli and Streptococcus pneumoniae, and fungi, such as Paracoccidioides brasiliensis, the causative agent of paracoccidioidomycosis. It is interesting that in the latter Galf is present in both anomeric configurations. Recent methods for the synthesis of galactofuranosides are included in this chapter. © 2012 by Nova Science Publishers, Inc. All rights reserved.
format CHAP
author Marino, C.
Gallo-Rodriguez, C.
de Lederkremer, R.M.
spellingShingle Marino, C.
Gallo-Rodriguez, C.
de Lederkremer, R.M.
Galactofuranosyl-containing glycans: Occurrence, synthesis and biochemistry
author_facet Marino, C.
Gallo-Rodriguez, C.
de Lederkremer, R.M.
author_sort Marino, C.
title Galactofuranosyl-containing glycans: Occurrence, synthesis and biochemistry
title_short Galactofuranosyl-containing glycans: Occurrence, synthesis and biochemistry
title_full Galactofuranosyl-containing glycans: Occurrence, synthesis and biochemistry
title_fullStr Galactofuranosyl-containing glycans: Occurrence, synthesis and biochemistry
title_full_unstemmed Galactofuranosyl-containing glycans: Occurrence, synthesis and biochemistry
title_sort galactofuranosyl-containing glycans: occurrence, synthesis and biochemistry
url http://hdl.handle.net/20.500.12110/paper_97816194_v_n_p207_Marino
work_keys_str_mv AT marinoc galactofuranosylcontainingglycansoccurrencesynthesisandbiochemistry
AT gallorodriguezc galactofuranosylcontainingglycansoccurrencesynthesisandbiochemistry
AT delederkremerrm galactofuranosylcontainingglycansoccurrencesynthesisandbiochemistry
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