NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction

Some decades ago it was postulated that gene expression regulation is required for long-term memory storage. In the last years, important progress has been made towards the characterization of these mechanisms of transcription. Among them, transcription factors play a key role. This chapter describe...

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Detalles Bibliográficos
Autor principal: Romano, A.
Formato: CHAP
Materias:
ΚB decoy
Consolidation
Extinction
Gene expression
IKK
Long-term memory
NF-κB
Reconsolidation
Sulfasalazine
Transcription factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_97816080_v_n_p97_Romano
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_97816080_v_n_p97_Romano
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spelling todo:paper_97816080_v_n_p97_Romano2023-10-03T16:44:10Z NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction Romano, A. ΚB decoy Consolidation Extinction Gene expression IKK Long-term memory NF-κB Reconsolidation Sulfasalazine Transcription factors Some decades ago it was postulated that gene expression regulation is required for long-term memory storage. In the last years, important progress has been made towards the characterization of these mechanisms of transcription. Among them, transcription factors play a key role. This chapter describes the characteristics and the role of one of these transcription factors, NF-κB, in the different phases of memory formation and processing. In more than a decade of research since the first data on the role of NF-κB in neuronal plasticity and memory, a growing body of evidence supports that this transcription factor is involved not only in the formation of the initial long-term memory traces but in the re-stabilization after memory reactivation induced by retrieval. Additionally, the role of NF-κB in the formation of memory extinction is now under study. Extinction entails a temporary inhibition of memory expression and entails a new memory process. Recent data support the inhibition of NF-κB in the formation of memory extinction. Here I propose the use of this transcription factor, together with other neuroplasticity-associated molecular mechanisms, as important tools for understanding the dynamics of the different phases of information processing as well as the determination of brain areas involved in such processes. Keywords: Long-term memory, consolidation, reconsolidation, extinction, gene expression, transcription factors, NF-kB, IKK, kB decoy, sulfasalazine. © 2012 Bentham Science Publishers. All rights reserved. CHAP info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_97816080_v_n_p97_Romano
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic ΚB decoy
Consolidation
Extinction
Gene expression
IKK
Long-term memory
NF-κB
Reconsolidation
Sulfasalazine
Transcription factors
spellingShingle ΚB decoy
Consolidation
Extinction
Gene expression
IKK
Long-term memory
NF-κB
Reconsolidation
Sulfasalazine
Transcription factors
Romano, A.
NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction
topic_facet ΚB decoy
Consolidation
Extinction
Gene expression
IKK
Long-term memory
NF-κB
Reconsolidation
Sulfasalazine
Transcription factors
description Some decades ago it was postulated that gene expression regulation is required for long-term memory storage. In the last years, important progress has been made towards the characterization of these mechanisms of transcription. Among them, transcription factors play a key role. This chapter describes the characteristics and the role of one of these transcription factors, NF-κB, in the different phases of memory formation and processing. In more than a decade of research since the first data on the role of NF-κB in neuronal plasticity and memory, a growing body of evidence supports that this transcription factor is involved not only in the formation of the initial long-term memory traces but in the re-stabilization after memory reactivation induced by retrieval. Additionally, the role of NF-κB in the formation of memory extinction is now under study. Extinction entails a temporary inhibition of memory expression and entails a new memory process. Recent data support the inhibition of NF-κB in the formation of memory extinction. Here I propose the use of this transcription factor, together with other neuroplasticity-associated molecular mechanisms, as important tools for understanding the dynamics of the different phases of information processing as well as the determination of brain areas involved in such processes. Keywords: Long-term memory, consolidation, reconsolidation, extinction, gene expression, transcription factors, NF-kB, IKK, kB decoy, sulfasalazine. © 2012 Bentham Science Publishers. All rights reserved.
format CHAP
author Romano, A.
author_facet Romano, A.
author_sort Romano, A.
title NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction
title_short NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction
title_full NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction
title_fullStr NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction
title_full_unstemmed NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction
title_sort nf-κb transcription factor: a model for the study of transcription regulation in memory consolidation, reconsolidation and extinction
url http://hdl.handle.net/20.500.12110/paper_97816080_v_n_p97_Romano
work_keys_str_mv AT romanoa nfkbtranscriptionfactoramodelforthestudyoftranscriptionregulationinmemoryconsolidationreconsolidationandextinction
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