Antiviral Properties of Brassinosteroids

In this chapter, we reviewed the antiviral activity of natural and synthetic brassinosteroids (BRs). Brassinolide and other natural BRs such as 28-homocastasterone present a broad antiviral spectrum against RNA and DNA viruses. Since the concentration of BRs in the plant tissue is very low, isolatio...

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Detalles Bibliográficos
Autores principales: Wachsman, M.B., Castilla, V.
Formato: CHAP
Materias:
Herpes simplex virus
Junín virus
Measles virus
Poliovirus
Ribavirin
Vesicular stomatitis
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_97816080_v_n_p57_Wachsman
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_97816080_v_n_p57_Wachsman
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spelling todo:paper_97816080_v_n_p57_Wachsman2023-10-03T16:44:10Z Antiviral Properties of Brassinosteroids Wachsman, M.B. Castilla, V. Herpes simplex virus Junín virus Measles virus Poliovirus Ribavirin Vesicular stomatitis In this chapter, we reviewed the antiviral activity of natural and synthetic brassinosteroids (BRs). Brassinolide and other natural BRs such as 28-homocastasterone present a broad antiviral spectrum against RNA and DNA viruses. Since the concentration of BRs in the plant tissue is very low, isolation of these compounds from plant sources is impractical, and they had to be obtained by chemical synthesis. The antiviral activity of a group of synthetic analogues against Herpes Simplex Type 1 and 2 (HSV-1 and HSV-2), Measles (MV), Vesicular Stomatitis Virus (VSV), Polio Virus (PV) and Arena Viruses was also determined. Several of the tested compounds showed selectivity indexes 10-to 18-fold higher than ribavirin, a broad spectrum antiviral compound, for Junín Virus (JUNV), a moderate activity against HSV-1/HSV-2 and good anti-MV, anti-PV and anti-VSV activity, with antiviral selectivity Index (SI) values also higher than ribavirin, a reference drug. Structure activity relationship Studies were performed in order to determine which stereochemistry, type and position of functional groups are needed to develop a potent and selective class of viral inhibitors. The antiviral mode of action of the BRs against HSV, JUNV and VSV was also investigated. For all assayed viruses, the antiviral compounds adversely affect virus protein synthesis and mature viral particle formation. © 2011 Bentham Science Publishers. All rights reserved. Fil:Wachsman, M.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Castilla, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. CHAP info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_97816080_v_n_p57_Wachsman
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Herpes simplex virus
Junín virus
Measles virus
Poliovirus
Ribavirin
Vesicular stomatitis
spellingShingle Herpes simplex virus
Junín virus
Measles virus
Poliovirus
Ribavirin
Vesicular stomatitis
Wachsman, M.B.
Castilla, V.
Antiviral Properties of Brassinosteroids
topic_facet Herpes simplex virus
Junín virus
Measles virus
Poliovirus
Ribavirin
Vesicular stomatitis
description In this chapter, we reviewed the antiviral activity of natural and synthetic brassinosteroids (BRs). Brassinolide and other natural BRs such as 28-homocastasterone present a broad antiviral spectrum against RNA and DNA viruses. Since the concentration of BRs in the plant tissue is very low, isolation of these compounds from plant sources is impractical, and they had to be obtained by chemical synthesis. The antiviral activity of a group of synthetic analogues against Herpes Simplex Type 1 and 2 (HSV-1 and HSV-2), Measles (MV), Vesicular Stomatitis Virus (VSV), Polio Virus (PV) and Arena Viruses was also determined. Several of the tested compounds showed selectivity indexes 10-to 18-fold higher than ribavirin, a broad spectrum antiviral compound, for Junín Virus (JUNV), a moderate activity against HSV-1/HSV-2 and good anti-MV, anti-PV and anti-VSV activity, with antiviral selectivity Index (SI) values also higher than ribavirin, a reference drug. Structure activity relationship Studies were performed in order to determine which stereochemistry, type and position of functional groups are needed to develop a potent and selective class of viral inhibitors. The antiviral mode of action of the BRs against HSV, JUNV and VSV was also investigated. For all assayed viruses, the antiviral compounds adversely affect virus protein synthesis and mature viral particle formation. © 2011 Bentham Science Publishers. All rights reserved.
format CHAP
author Wachsman, M.B.
Castilla, V.
author_facet Wachsman, M.B.
Castilla, V.
author_sort Wachsman, M.B.
title Antiviral Properties of Brassinosteroids
title_short Antiviral Properties of Brassinosteroids
title_full Antiviral Properties of Brassinosteroids
title_fullStr Antiviral Properties of Brassinosteroids
title_full_unstemmed Antiviral Properties of Brassinosteroids
title_sort antiviral properties of brassinosteroids
url http://hdl.handle.net/20.500.12110/paper_97816080_v_n_p57_Wachsman
work_keys_str_mv AT wachsmanmb antiviralpropertiesofbrassinosteroids
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