Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation

The neural cell adhesion molecule (NCAM; CD56) is a member of the immunoglobulin protein superfamily. It has been described as a key molecule for the regulation of neuronal differentiation, synaptogenesis, memory formation, and neuronal plasticity. Alternative splicing gives rise to at least 20-30 N...

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Autores principales: Fiszbein, A., Schor, I.E., Kornblihtt, A.R.
Formato: CHAP
Materias:
Alternative splicing
CD56
Chromatin structure
NCAM
Neuronal differentiation
Transcription rate
Cell adhesion
Chromosomes
Molecules
Neurons
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_97801280_v_n_p131_Fiszbein
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_97801280_v_n_p131_Fiszbein
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spelling todo:paper_97801280_v_n_p131_Fiszbein2023-10-03T16:42:40Z Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation Fiszbein, A. Schor, I.E. Kornblihtt, A.R. Alternative splicing CD56 Chromatin structure NCAM Neuronal differentiation Transcription rate Cell adhesion Chromosomes Molecules Alternative splicing CD56 Chromatin structure NCAM Neuronal differentiation Neurons The neural cell adhesion molecule (NCAM; CD56) is a member of the immunoglobulin protein superfamily. It has been described as a key molecule for the regulation of neuronal differentiation, synaptogenesis, memory formation, and neuronal plasticity. Alternative splicing gives rise to at least 20-30 NCAM isoforms in mice and humans, NCAM120, NCAM140, and NCAM180 being the more abundant. There are many different modes of alternative splicing; the difference between NCAM140 and NCAM180 is the inclusion or exclusion of an alternative exon. During neuronal differentiation, the alternative splicing pattern of NCAM changes, favoring the expression of NCAM180 to the detriment of NCAM140. In this work we review the most relevant information about NCAM structure and function and present the molecular basis of alternative splicing and its regulation with particular emphasis on how changes in chromatin structure are key for the regulation of NCAM splicing during neuronal differentiation and upon membrane depolarization. © 2015 Elsevier Inc. All rights reserved. Fil:Fiszbein, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Schor, I.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. CHAP info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_97801280_v_n_p131_Fiszbein
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Alternative splicing
CD56
Chromatin structure
NCAM
Neuronal differentiation
Transcription rate
Cell adhesion
Chromosomes
Molecules
Alternative splicing
CD56
Chromatin structure
NCAM
Neuronal differentiation
Neurons
spellingShingle Alternative splicing
CD56
Chromatin structure
NCAM
Neuronal differentiation
Transcription rate
Cell adhesion
Chromosomes
Molecules
Alternative splicing
CD56
Chromatin structure
NCAM
Neuronal differentiation
Neurons
Fiszbein, A.
Schor, I.E.
Kornblihtt, A.R.
Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation
topic_facet Alternative splicing
CD56
Chromatin structure
NCAM
Neuronal differentiation
Transcription rate
Cell adhesion
Chromosomes
Molecules
Alternative splicing
CD56
Chromatin structure
NCAM
Neuronal differentiation
Neurons
description The neural cell adhesion molecule (NCAM; CD56) is a member of the immunoglobulin protein superfamily. It has been described as a key molecule for the regulation of neuronal differentiation, synaptogenesis, memory formation, and neuronal plasticity. Alternative splicing gives rise to at least 20-30 NCAM isoforms in mice and humans, NCAM120, NCAM140, and NCAM180 being the more abundant. There are many different modes of alternative splicing; the difference between NCAM140 and NCAM180 is the inclusion or exclusion of an alternative exon. During neuronal differentiation, the alternative splicing pattern of NCAM changes, favoring the expression of NCAM180 to the detriment of NCAM140. In this work we review the most relevant information about NCAM structure and function and present the molecular basis of alternative splicing and its regulation with particular emphasis on how changes in chromatin structure are key for the regulation of NCAM splicing during neuronal differentiation and upon membrane depolarization. © 2015 Elsevier Inc. All rights reserved.
format CHAP
author Fiszbein, A.
Schor, I.E.
Kornblihtt, A.R.
author_facet Fiszbein, A.
Schor, I.E.
Kornblihtt, A.R.
author_sort Fiszbein, A.
title Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation
title_short Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation
title_full Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation
title_fullStr Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation
title_full_unstemmed Fundamentals of NCAM Expression, Function, and Regulation of Alternative Splicing in Neuronal Differentiation
title_sort fundamentals of ncam expression, function, and regulation of alternative splicing in neuronal differentiation
url http://hdl.handle.net/20.500.12110/paper_97801280_v_n_p131_Fiszbein
work_keys_str_mv AT fiszbeina fundamentalsofncamexpressionfunctionandregulationofalternativesplicinginneuronaldifferentiation
AT schorie fundamentalsofncamexpressionfunctionandregulationofalternativesplicinginneuronaldifferentiation
AT kornblihttar fundamentalsofncamexpressionfunctionandregulationofalternativesplicinginneuronaldifferentiation
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