Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression

Cells may control fluctuations in protein levels by means of negative autoregulation, where transcription factors bind DNA sites to repress their own production. Theoretical studies have assumed a single binding site for the repressor, while in most species it is found that multiple binding sites ar...

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Detalles Bibliográficos
Autores principales: Lengyel, I.M., Morelli, L.G.
Formato: JOUR
Materias:
Bins
Stochastic systems
Transcription
Gene products
Multiple binding sites
Negative autoregulation
Noise suppression
Protein level
Single binding sites
Theoretical study
Transcriptional repressors
Binding sites
DNA
transcription factor
binding site
biological model
gene expression regulation
kinetics
Markov chain
metabolism
physiology
protein degradation
Binding Sites
Gene Expression Regulation
Kinetics
Models, Genetic
Proteolysis
Stochastic Processes
Transcription Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_24700045_v95_n4_p_Lengyel
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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