Histone methylation, alternative splicing and neuronal differentiation
Alternative splicing, as well as chromatin structure, greatly contributes to specific transcriptional programs that promote neuronal differentiation. The activity of G9a, the enzyme responsible for mono- and di-methylation of lysine 9 on histone H3 (H3K9me1 and H3K9me2) in mammalian euchromatin, has...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_23262133_v3_n1_p_Fiszbein |
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todo:paper_23262133_v3_n1_p_Fiszbein2023-10-03T16:41:00Z Histone methylation, alternative splicing and neuronal differentiation Fiszbein, A. Kornblihtt, A.R. Alternative splicing Chromatin modifiers G9a H3K9me Neuronal differentiation cyclic AMP responsive element binding protein binding protein histone H3 lysine specific demethylase 1 transcription factor unclassified drug alternative RNA splicing cell differentiation chromatin structure embryonic stem cell euchromatin gene expression regulation gene mutation histone demethylation histone methylation human immunofluorescence nerve cell differentiation nonhuman Note nuclear localization signal priority journal regulatory mechanism RNA processing Alternative splicing, as well as chromatin structure, greatly contributes to specific transcriptional programs that promote neuronal differentiation. The activity of G9a, the enzyme responsible for mono- and di-methylation of lysine 9 on histone H3 (H3K9me1 and H3K9me2) in mammalian euchromatin, has been widely implicated in the differentiation of a variety of cell types and tissues. In a recent work from our group (Fiszbein et al., 2016) we have shown that alternative splicing of G9a regulates its nuclear localization and, therefore, the efficiency of H3K9 methylation, which promotes neuronal differentiation. We discuss here our results in the light of a report from other group (Laurent et al. 2015) demonstrating a key role for the alternative splicing of the histone demethylase LSD1 in controlling specific gene expression in neurons. All together, these results illustrate the importance of alternative splicing in the generation of a proper equilibrium between methylation and demethylation of histones for the regulation of neuron-specific transcriptional programs. © 2016 Taylor & Francis. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_23262133_v3_n1_p_Fiszbein |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Alternative splicing Chromatin modifiers G9a H3K9me Neuronal differentiation cyclic AMP responsive element binding protein binding protein histone H3 lysine specific demethylase 1 transcription factor unclassified drug alternative RNA splicing cell differentiation chromatin structure embryonic stem cell euchromatin gene expression regulation gene mutation histone demethylation histone methylation human immunofluorescence nerve cell differentiation nonhuman Note nuclear localization signal priority journal regulatory mechanism RNA processing |
| spellingShingle |
Alternative splicing Chromatin modifiers G9a H3K9me Neuronal differentiation cyclic AMP responsive element binding protein binding protein histone H3 lysine specific demethylase 1 transcription factor unclassified drug alternative RNA splicing cell differentiation chromatin structure embryonic stem cell euchromatin gene expression regulation gene mutation histone demethylation histone methylation human immunofluorescence nerve cell differentiation nonhuman Note nuclear localization signal priority journal regulatory mechanism RNA processing Fiszbein, A. Kornblihtt, A.R. Histone methylation, alternative splicing and neuronal differentiation |
| topic_facet |
Alternative splicing Chromatin modifiers G9a H3K9me Neuronal differentiation cyclic AMP responsive element binding protein binding protein histone H3 lysine specific demethylase 1 transcription factor unclassified drug alternative RNA splicing cell differentiation chromatin structure embryonic stem cell euchromatin gene expression regulation gene mutation histone demethylation histone methylation human immunofluorescence nerve cell differentiation nonhuman Note nuclear localization signal priority journal regulatory mechanism RNA processing |
| description |
Alternative splicing, as well as chromatin structure, greatly contributes to specific transcriptional programs that promote neuronal differentiation. The activity of G9a, the enzyme responsible for mono- and di-methylation of lysine 9 on histone H3 (H3K9me1 and H3K9me2) in mammalian euchromatin, has been widely implicated in the differentiation of a variety of cell types and tissues. In a recent work from our group (Fiszbein et al., 2016) we have shown that alternative splicing of G9a regulates its nuclear localization and, therefore, the efficiency of H3K9 methylation, which promotes neuronal differentiation. We discuss here our results in the light of a report from other group (Laurent et al. 2015) demonstrating a key role for the alternative splicing of the histone demethylase LSD1 in controlling specific gene expression in neurons. All together, these results illustrate the importance of alternative splicing in the generation of a proper equilibrium between methylation and demethylation of histones for the regulation of neuron-specific transcriptional programs. © 2016 Taylor & Francis. |
| format |
JOUR |
| author |
Fiszbein, A. Kornblihtt, A.R. |
| author_facet |
Fiszbein, A. Kornblihtt, A.R. |
| author_sort |
Fiszbein, A. |
| title |
Histone methylation, alternative splicing and neuronal differentiation |
| title_short |
Histone methylation, alternative splicing and neuronal differentiation |
| title_full |
Histone methylation, alternative splicing and neuronal differentiation |
| title_fullStr |
Histone methylation, alternative splicing and neuronal differentiation |
| title_full_unstemmed |
Histone methylation, alternative splicing and neuronal differentiation |
| title_sort |
histone methylation, alternative splicing and neuronal differentiation |
| url |
http://hdl.handle.net/20.500.12110/paper_23262133_v3_n1_p_Fiszbein |
| work_keys_str_mv |
AT fiszbeina histonemethylationalternativesplicingandneuronaldifferentiation AT kornblihttar histonemethylationalternativesplicingandneuronaldifferentiation |
| _version_ |
1807323673256787968 |