Autoimmunity in amyotrophic lateral sclerosis: Past and present

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting particularly motor neurons for which no cure or effective treatment is available. Although the cause of ALS remains unknown, accumulative evidence suggests an autoimmune mechanism of pathogenesis. In this paper, we wi...

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Autores principales: Pagani, M.R., Gonzalez, L.E., Uchitel, O.D.
Formato: JOUR
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_20901852_v2011_n_p_Pagani
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_20901852_v2011_n_p_Pagani2023-10-03T16:39:20Z Autoimmunity in amyotrophic lateral sclerosis: Past and present Pagani, M.R. Gonzalez, L.E. Uchitel, O.D. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting particularly motor neurons for which no cure or effective treatment is available. Although the cause of ALS remains unknown, accumulative evidence suggests an autoimmune mechanism of pathogenesis. In this paper, we will summarize the current research related to autoimmunity in the sporadic form of ALS and discuss the potential underlying pathogenic mechanisms and perspectives. Presented data supports the view that humoral immune responses against motor nerve terminals can initiate a series of physiological changes leading to alteration of calcium homeostasis. In turn, loss of calcium homeostasis may induce neuronal death through apoptotic signaling pathways. Additional approaches identifying specific molecular features of this hypothesis are required, which will hopefully allow us to develop techniques of early diagnosis and effective therapies. Copyright © 2011 Mario Rafael Pagani et al. Fil:Pagani, M.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gonzalez, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Uchitel, O.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_20901852_v2011_n_p_Pagani
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
description Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting particularly motor neurons for which no cure or effective treatment is available. Although the cause of ALS remains unknown, accumulative evidence suggests an autoimmune mechanism of pathogenesis. In this paper, we will summarize the current research related to autoimmunity in the sporadic form of ALS and discuss the potential underlying pathogenic mechanisms and perspectives. Presented data supports the view that humoral immune responses against motor nerve terminals can initiate a series of physiological changes leading to alteration of calcium homeostasis. In turn, loss of calcium homeostasis may induce neuronal death through apoptotic signaling pathways. Additional approaches identifying specific molecular features of this hypothesis are required, which will hopefully allow us to develop techniques of early diagnosis and effective therapies. Copyright © 2011 Mario Rafael Pagani et al.
format JOUR
author Pagani, M.R.
Gonzalez, L.E.
Uchitel, O.D.
spellingShingle Pagani, M.R.
Gonzalez, L.E.
Uchitel, O.D.
Autoimmunity in amyotrophic lateral sclerosis: Past and present
author_facet Pagani, M.R.
Gonzalez, L.E.
Uchitel, O.D.
author_sort Pagani, M.R.
title Autoimmunity in amyotrophic lateral sclerosis: Past and present
title_short Autoimmunity in amyotrophic lateral sclerosis: Past and present
title_full Autoimmunity in amyotrophic lateral sclerosis: Past and present
title_fullStr Autoimmunity in amyotrophic lateral sclerosis: Past and present
title_full_unstemmed Autoimmunity in amyotrophic lateral sclerosis: Past and present
title_sort autoimmunity in amyotrophic lateral sclerosis: past and present
url http://hdl.handle.net/20.500.12110/paper_20901852_v2011_n_p_Pagani
work_keys_str_mv AT paganimr autoimmunityinamyotrophiclateralsclerosispastandpresent
AT gonzalezle autoimmunityinamyotrophiclateralsclerosispastandpresent
AT uchitelod autoimmunityinamyotrophiclateralsclerosispastandpresent
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