Absorption and photo-stability of substituted dibenzoylmethanes and chalcones as UVA filters

There is still an international need to develop broad-spectrum sunscreen products with an adequate UVB/UVA balance, while the approved filters available in the UVA are scarce. Currently, one of the few UVA filters approved in the United States and Europe is tert-butylmethoxydibenzoylmethane (BMDM, a...

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Autores principales:	Lazópulos, S.Q., Svarc, F., Sagrera, G., Dicelio, L.
Formato:	JOUR
Materias:	Chalcones Dibenzoylmethanes Photo-stability UVA filters
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_20799284_v5_n2_p_Lazopulos
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_20799284_v5_n2_p_Lazopulos
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spelling	todo:paper_20799284_v5_n2_p_Lazopulos2023-10-03T16:39:19Z Absorption and photo-stability of substituted dibenzoylmethanes and chalcones as UVA filters Lazópulos, S.Q. Svarc, F. Sagrera, G. Dicelio, L. Chalcones Dibenzoylmethanes Photo-stability UVA filters There is still an international need to develop broad-spectrum sunscreen products with an adequate UVB/UVA balance, while the approved filters available in the UVA are scarce. Currently, one of the few UVA filters approved in the United States and Europe is tert-butylmethoxydibenzoylmethane (BMDM, avobenzone). However, this compound is unstable from aphotochemical point of view and cannot be used in combination with certain sunscreens. In this paper, we investigate the photochemical behavior of a set of dibenzoylmethanes and chalcones. In particular, we carry out their absorption and emission spectra, evaluate their photochemical degradation, and study their generation of free radicals and singlet oxygen photoproduction. Two compounds resultedin having the basic properties of UVA filters (2'-hydroxy-4-methoxychalcone and 2'-hydroxy-4-methoxydibenzoylmethane). Further studies are proposed, such as formulating the compounds into emulsions or other common cosmetic presentations, as well as combining them with broadly-used UVB filters. We have also considered the need to establish its toxicological profile. © 2018 by the authors. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_20799284_v5_n2_p_Lazopulos
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Chalcones Dibenzoylmethanes Photo-stability UVA filters
spellingShingle	Chalcones Dibenzoylmethanes Photo-stability UVA filters Lazópulos, S.Q. Svarc, F. Sagrera, G. Dicelio, L. Absorption and photo-stability of substituted dibenzoylmethanes and chalcones as UVA filters
topic_facet	Chalcones Dibenzoylmethanes Photo-stability UVA filters
description	There is still an international need to develop broad-spectrum sunscreen products with an adequate UVB/UVA balance, while the approved filters available in the UVA are scarce. Currently, one of the few UVA filters approved in the United States and Europe is tert-butylmethoxydibenzoylmethane (BMDM, avobenzone). However, this compound is unstable from aphotochemical point of view and cannot be used in combination with certain sunscreens. In this paper, we investigate the photochemical behavior of a set of dibenzoylmethanes and chalcones. In particular, we carry out their absorption and emission spectra, evaluate their photochemical degradation, and study their generation of free radicals and singlet oxygen photoproduction. Two compounds resultedin having the basic properties of UVA filters (2'-hydroxy-4-methoxychalcone and 2'-hydroxy-4-methoxydibenzoylmethane). Further studies are proposed, such as formulating the compounds into emulsions or other common cosmetic presentations, as well as combining them with broadly-used UVB filters. We have also considered the need to establish its toxicological profile. © 2018 by the authors.
format	JOUR
author	Lazópulos, S.Q. Svarc, F. Sagrera, G. Dicelio, L.
author_facet	Lazópulos, S.Q. Svarc, F. Sagrera, G. Dicelio, L.
author_sort	Lazópulos, S.Q.
title	Absorption and photo-stability of substituted dibenzoylmethanes and chalcones as UVA filters
title_short	Absorption and photo-stability of substituted dibenzoylmethanes and chalcones as UVA filters
title_full	Absorption and photo-stability of substituted dibenzoylmethanes and chalcones as UVA filters
title_fullStr	Absorption and photo-stability of substituted dibenzoylmethanes and chalcones as UVA filters
title_full_unstemmed	Absorption and photo-stability of substituted dibenzoylmethanes and chalcones as UVA filters
title_sort	absorption and photo-stability of substituted dibenzoylmethanes and chalcones as uva filters
url	http://hdl.handle.net/20.500.12110/paper_20799284_v5_n2_p_Lazopulos
work_keys_str_mv	AT lazopulossq absorptionandphotostabilityofsubstituteddibenzoylmethanesandchalconesasuvafilters AT svarcf absorptionandphotostabilityofsubstituteddibenzoylmethanesandchalconesasuvafilters AT sagrerag absorptionandphotostabilityofsubstituteddibenzoylmethanesandchalconesasuvafilters AT diceliol absorptionandphotostabilityofsubstituteddibenzoylmethanesandchalconesasuvafilters
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Absorption and photo-stability of substituted dibenzoylmethanes and chalcones as UVA filters

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