The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina
Interferon gamma (IFNG) plays a key role during Mycobacterium tuberculosis (Mtb) infection, and several polymorphisms located in its gene are associated with risk of tuberculosis in diverse populations. Nevertheless, the genetic resistance/susceptibility to tuberculosis in Argentina is unknown. The...
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todo:paper_20734425_v9_n1_p_Rolandelli2023-10-03T16:39:12Z The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina Rolandelli, A. Pellegrini, J.M. Amiano, N.O. Santilli, M.C. Morelli, M.P. Castello, F.A. Tateosian, N.L. Levi, A. Casco, N. Palmero, D.J. García, V.E. Interferon gamma Mycobacterium tuberculosis Rs1861494 Single nucleotide polymorphism Tuberculosis biological marker CD4 antigen gamma interferon Mycobacterium antigen adult allele Argentina Article bacterial strain case control study CD4+ T lymphocyte controlled study disease resistance disease severity female gene frequency gene function gene location genetic association genetic variation genotype human human cell IFNG gene immune response major clinical study male Mycobacterium tuberculosis nonhuman peripheral blood mononuclear cell single nucleotide polymorphism tuberculosis Interferon gamma (IFNG) plays a key role during Mycobacterium tuberculosis (Mtb) infection, and several polymorphisms located in its gene are associated with risk of tuberculosis in diverse populations. Nevertheless, the genetic resistance/susceptibility to tuberculosis in Argentina is unknown. The IFNG rs1861494 polymorphism (G→A) was reported to alter the binding of transcription factors to this region, influencing IFNG production. Using a case-control study, we found an association between the AA and AG genotypes and tuberculosis resistance (AA vs. GG: odds ratio (OR) = 0.235, p-value = 0.012; AG vs. GG: OR = 0.303, p-value = 0.044; AA vs. AG: OR = 0.776, p-value = 0.427; AA + AG vs. GG: OR = 0.270, p-value = 0.022). Moreover, Mtb-antigen stimulated peripheral blood mononuclear cells (PBMCs) from healthy donors and AA carriers secreted the highest amounts of IFNG in culture supernatants (p-value = 0.034) and presented the greatest percentage of CD4+IFNG+ lymphocytes (p-value = 0.035), in comparison with GG carriers. No association between the polymorphism and clinical parameters of tuberculosis severity was detected. However, our findings indicate that the rs1861494 single nucleotide polymorphism (SNP) could be considered as a biomarker of tuberculosis resistance in the Argentinean population. © 2018 by the authors. Licensee MDPI, Basel, Switzerland. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_20734425_v9_n1_p_Rolandelli |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Interferon gamma Mycobacterium tuberculosis Rs1861494 Single nucleotide polymorphism Tuberculosis biological marker CD4 antigen gamma interferon Mycobacterium antigen adult allele Argentina Article bacterial strain case control study CD4+ T lymphocyte controlled study disease resistance disease severity female gene frequency gene function gene location genetic association genetic variation genotype human human cell IFNG gene immune response major clinical study male Mycobacterium tuberculosis nonhuman peripheral blood mononuclear cell single nucleotide polymorphism tuberculosis |
| spellingShingle |
Interferon gamma Mycobacterium tuberculosis Rs1861494 Single nucleotide polymorphism Tuberculosis biological marker CD4 antigen gamma interferon Mycobacterium antigen adult allele Argentina Article bacterial strain case control study CD4+ T lymphocyte controlled study disease resistance disease severity female gene frequency gene function gene location genetic association genetic variation genotype human human cell IFNG gene immune response major clinical study male Mycobacterium tuberculosis nonhuman peripheral blood mononuclear cell single nucleotide polymorphism tuberculosis Rolandelli, A. Pellegrini, J.M. Amiano, N.O. Santilli, M.C. Morelli, M.P. Castello, F.A. Tateosian, N.L. Levi, A. Casco, N. Palmero, D.J. García, V.E. The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina |
| topic_facet |
Interferon gamma Mycobacterium tuberculosis Rs1861494 Single nucleotide polymorphism Tuberculosis biological marker CD4 antigen gamma interferon Mycobacterium antigen adult allele Argentina Article bacterial strain case control study CD4+ T lymphocyte controlled study disease resistance disease severity female gene frequency gene function gene location genetic association genetic variation genotype human human cell IFNG gene immune response major clinical study male Mycobacterium tuberculosis nonhuman peripheral blood mononuclear cell single nucleotide polymorphism tuberculosis |
| description |
Interferon gamma (IFNG) plays a key role during Mycobacterium tuberculosis (Mtb) infection, and several polymorphisms located in its gene are associated with risk of tuberculosis in diverse populations. Nevertheless, the genetic resistance/susceptibility to tuberculosis in Argentina is unknown. The IFNG rs1861494 polymorphism (G→A) was reported to alter the binding of transcription factors to this region, influencing IFNG production. Using a case-control study, we found an association between the AA and AG genotypes and tuberculosis resistance (AA vs. GG: odds ratio (OR) = 0.235, p-value = 0.012; AG vs. GG: OR = 0.303, p-value = 0.044; AA vs. AG: OR = 0.776, p-value = 0.427; AA + AG vs. GG: OR = 0.270, p-value = 0.022). Moreover, Mtb-antigen stimulated peripheral blood mononuclear cells (PBMCs) from healthy donors and AA carriers secreted the highest amounts of IFNG in culture supernatants (p-value = 0.034) and presented the greatest percentage of CD4+IFNG+ lymphocytes (p-value = 0.035), in comparison with GG carriers. No association between the polymorphism and clinical parameters of tuberculosis severity was detected. However, our findings indicate that the rs1861494 single nucleotide polymorphism (SNP) could be considered as a biomarker of tuberculosis resistance in the Argentinean population. © 2018 by the authors. Licensee MDPI, Basel, Switzerland. |
| format |
JOUR |
| author |
Rolandelli, A. Pellegrini, J.M. Amiano, N.O. Santilli, M.C. Morelli, M.P. Castello, F.A. Tateosian, N.L. Levi, A. Casco, N. Palmero, D.J. García, V.E. |
| author_facet |
Rolandelli, A. Pellegrini, J.M. Amiano, N.O. Santilli, M.C. Morelli, M.P. Castello, F.A. Tateosian, N.L. Levi, A. Casco, N. Palmero, D.J. García, V.E. |
| author_sort |
Rolandelli, A. |
| title |
The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina |
| title_short |
The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina |
| title_full |
The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina |
| title_fullStr |
The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina |
| title_full_unstemmed |
The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina |
| title_sort |
ifng rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in argentina |
| url |
http://hdl.handle.net/20.500.12110/paper_20734425_v9_n1_p_Rolandelli |
| work_keys_str_mv |
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