Endocrinology and the brain: Corticotropin-releasing hormone signaling

Corticotropin-releasing hormone (CRH) is a key player of basal and stress-activated responses in the hypothalamic–pituitary–adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavioral adaptive responses to stress. This review des...

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Autores principales:	Inda, C., Armando, N.G., dos Santos Claro, P.A., Silberstein, S.
Formato:	JOUR
Materias:	CAMP CRH receptors signaling CRH system pathophysiology ERK1/2 GPCR endocytosis and signaling beta 2 adrenergic receptor beta arrestin corticosteroid corticotropin releasing factor cyclic AMP G protein coupled receptor glucocorticoid mitogen activated protein kinase 1 mitogen activated protein kinase 3 neurotransmitter sauvagine sphingosine 1 phosphate receptor thyrotropin urocortin vasopressin receptor brain cognitive defect cytology desensitization endocrinology endocytosis heart function HEK293 cell line hypothalamus hypophysis adrenal system learning liver molecular biology nerve cell plasticity neuroblastoma cell noradrenalin release phosphorylation placenta priority journal Review stress
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_20493614_v6_n6_pR99_Inda
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_20493614_v6_n6_pR99_Inda2023-10-03T16:38:43Z Endocrinology and the brain: Corticotropin-releasing hormone signaling Inda, C. Armando, N.G. dos Santos Claro, P.A. Silberstein, S. CAMP CRH receptors signaling CRH system pathophysiology ERK1/2 GPCR endocytosis and signaling beta 2 adrenergic receptor beta arrestin corticosteroid corticotropin releasing factor cyclic AMP G protein coupled receptor glucocorticoid mitogen activated protein kinase 1 mitogen activated protein kinase 3 neurotransmitter sauvagine sphingosine 1 phosphate receptor thyrotropin urocortin vasopressin receptor brain cognitive defect cytology desensitization endocrinology endocytosis heart function HEK293 cell line hypothalamus hypophysis adrenal system learning liver molecular biology nerve cell plasticity neuroblastoma cell noradrenalin release phosphorylation placenta priority journal Review stress Corticotropin-releasing hormone (CRH) is a key player of basal and stress-activated responses in the hypothalamic–pituitary–adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavioral adaptive responses to stress. This review describes molecular components and cellular mechanisms involved in CRH signaling downstream of its G protein-coupled receptors (GPCRs) CRHR1 and CRHR2 and summarizes recent findings that challenge the classical view of GPCR signaling and impact on our understanding of CRHRs function. Special emphasis is placed on recent studies of CRH signaling that revealed new mechanistic aspects of cAMP generation and ERK1/2 activation in physiologically relevant contexts of the neurohormone action. In addition, we present an overview of the pathophysiological role of the CRH system, which highlights the need for a precise definition of CRHRs signaling at molecular level to identify novel targets for pharmacological intervention in neuroendocrine tissues and specific brain areas involved in CRH-related disorders. © 2017 The authors Published by Bioscientifica Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_20493614_v6_n6_pR99_Inda
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	CAMP CRH receptors signaling CRH system pathophysiology ERK1/2 GPCR endocytosis and signaling beta 2 adrenergic receptor beta arrestin corticosteroid corticotropin releasing factor cyclic AMP G protein coupled receptor glucocorticoid mitogen activated protein kinase 1 mitogen activated protein kinase 3 neurotransmitter sauvagine sphingosine 1 phosphate receptor thyrotropin urocortin vasopressin receptor brain cognitive defect cytology desensitization endocrinology endocytosis heart function HEK293 cell line hypothalamus hypophysis adrenal system learning liver molecular biology nerve cell plasticity neuroblastoma cell noradrenalin release phosphorylation placenta priority journal Review stress
spellingShingle	CAMP CRH receptors signaling CRH system pathophysiology ERK1/2 GPCR endocytosis and signaling beta 2 adrenergic receptor beta arrestin corticosteroid corticotropin releasing factor cyclic AMP G protein coupled receptor glucocorticoid mitogen activated protein kinase 1 mitogen activated protein kinase 3 neurotransmitter sauvagine sphingosine 1 phosphate receptor thyrotropin urocortin vasopressin receptor brain cognitive defect cytology desensitization endocrinology endocytosis heart function HEK293 cell line hypothalamus hypophysis adrenal system learning liver molecular biology nerve cell plasticity neuroblastoma cell noradrenalin release phosphorylation placenta priority journal Review stress Inda, C. Armando, N.G. dos Santos Claro, P.A. Silberstein, S. Endocrinology and the brain: Corticotropin-releasing hormone signaling
topic_facet	CAMP CRH receptors signaling CRH system pathophysiology ERK1/2 GPCR endocytosis and signaling beta 2 adrenergic receptor beta arrestin corticosteroid corticotropin releasing factor cyclic AMP G protein coupled receptor glucocorticoid mitogen activated protein kinase 1 mitogen activated protein kinase 3 neurotransmitter sauvagine sphingosine 1 phosphate receptor thyrotropin urocortin vasopressin receptor brain cognitive defect cytology desensitization endocrinology endocytosis heart function HEK293 cell line hypothalamus hypophysis adrenal system learning liver molecular biology nerve cell plasticity neuroblastoma cell noradrenalin release phosphorylation placenta priority journal Review stress
description	Corticotropin-releasing hormone (CRH) is a key player of basal and stress-activated responses in the hypothalamic–pituitary–adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavioral adaptive responses to stress. This review describes molecular components and cellular mechanisms involved in CRH signaling downstream of its G protein-coupled receptors (GPCRs) CRHR1 and CRHR2 and summarizes recent findings that challenge the classical view of GPCR signaling and impact on our understanding of CRHRs function. Special emphasis is placed on recent studies of CRH signaling that revealed new mechanistic aspects of cAMP generation and ERK1/2 activation in physiologically relevant contexts of the neurohormone action. In addition, we present an overview of the pathophysiological role of the CRH system, which highlights the need for a precise definition of CRHRs signaling at molecular level to identify novel targets for pharmacological intervention in neuroendocrine tissues and specific brain areas involved in CRH-related disorders. © 2017 The authors Published by Bioscientifica Ltd.
format	JOUR
author	Inda, C. Armando, N.G. dos Santos Claro, P.A. Silberstein, S.
author_facet	Inda, C. Armando, N.G. dos Santos Claro, P.A. Silberstein, S.
author_sort	Inda, C.
title	Endocrinology and the brain: Corticotropin-releasing hormone signaling
title_short	Endocrinology and the brain: Corticotropin-releasing hormone signaling
title_full	Endocrinology and the brain: Corticotropin-releasing hormone signaling
title_fullStr	Endocrinology and the brain: Corticotropin-releasing hormone signaling
title_full_unstemmed	Endocrinology and the brain: Corticotropin-releasing hormone signaling
title_sort	endocrinology and the brain: corticotropin-releasing hormone signaling
url	http://hdl.handle.net/20.500.12110/paper_20493614_v6_n6_pR99_Inda
work_keys_str_mv	AT indac endocrinologyandthebraincorticotropinreleasinghormonesignaling AT armandong endocrinologyandthebraincorticotropinreleasinghormonesignaling AT dossantosclaropa endocrinologyandthebraincorticotropinreleasinghormonesignaling AT silbersteins endocrinologyandthebraincorticotropinreleasinghormonesignaling
_version_	1782025895507132416

Endocrinology and the brain: Corticotropin-releasing hormone signaling

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