The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina

Mycobacterium tuberculosis (Mtb) causes nearly 10 millions of new tuberculosis disease cases annually. However, most individuals exposed to Mtb do not develop tuberculosis, suggesting the influence of a human genetic component. Here, we investigated the association of the rs2275913 SNP (G → A) from...

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Autores principales: Rolandelli, A., Del Pino, R.E.H., Pellegrini, J.M., Tateosian, N.L., Amiano, N.O., De La Barrera, S., Casco, N., Gutiérrez, M., Palmero, D.J., García, V.E.
Formato: JOUR
Materias:
gamma interferon
IL17A protein, human
interleukin 17
adult
allele
Argentina
blood
female
gene frequency
genetic predisposition
genetics
genotype
human
male
middle aged
severity of illness index
single nucleotide polymorphism
tuberculosis
Adult
Alleles
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Interferon-gamma
Interleukin-17
Male
Middle Aged
Polymorphism, Single Nucleotide
Severity of Illness Index
Tuberculosis
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_20452322_v7_n_p_Rolandelli
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_20452322_v7_n_p_Rolandelli
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spelling todo:paper_20452322_v7_n_p_Rolandelli2023-10-03T16:38:22Z The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina Rolandelli, A. Del Pino, R.E.H. Pellegrini, J.M. Tateosian, N.L. Amiano, N.O. De La Barrera, S. Casco, N. Gutiérrez, M. Palmero, D.J. García, V.E. gamma interferon IL17A protein, human interleukin 17 adult allele Argentina blood female gene frequency genetic predisposition genetics genotype human male middle aged severity of illness index single nucleotide polymorphism tuberculosis Adult Alleles Argentina Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Interferon-gamma Interleukin-17 Male Middle Aged Polymorphism, Single Nucleotide Severity of Illness Index Tuberculosis Mycobacterium tuberculosis (Mtb) causes nearly 10 millions of new tuberculosis disease cases annually. However, most individuals exposed to Mtb do not develop tuberculosis, suggesting the influence of a human genetic component. Here, we investigated the association of the rs2275913 SNP (G → A) from IL-17A and tuberculosis in Argentina by a case-control study. Furthermore, we evaluated in vitro the functional relevance of this SNP during the immune response of the host against Mtb and analyzed its impact on clinical parameters of the disease. We found an association between the AA genotype and tuberculosis resistance. Additionally, within the healthy donors population, AA cells stimulated with a Mtb lysate (Mtb-Ag) produced the highest amounts of IL-17A and IFN-γ, which further support the genetic evidence found. In contrast, within the tuberculosis patients population, AA Mtb-Ag stimulated cells showed the lowest immunological parameters and we evidenced an association between the AA genotype and clinical parameters of disease severity, such as severe radiological lesions and higher bacilli burden in sputum. Overall, our findings demonstrated that the AA genotype from the IL-17A rs2275913 SNP is positively associated with protection to active tuberculosis but related to higher disease severity in the Argentinean population. © The Author(s) 2017. Fil:Amiano, N.O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:García, V.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_20452322_v7_n_p_Rolandelli
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic gamma interferon
IL17A protein, human
interleukin 17
adult
allele
Argentina
blood
female
gene frequency
genetic predisposition
genetics
genotype
human
male
middle aged
severity of illness index
single nucleotide polymorphism
tuberculosis
Adult
Alleles
Argentina
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Interferon-gamma
Interleukin-17
Male
Middle Aged
Polymorphism, Single Nucleotide
Severity of Illness Index
Tuberculosis
spellingShingle gamma interferon
IL17A protein, human
interleukin 17
adult
allele
Argentina
blood
female
gene frequency
genetic predisposition
genetics
genotype
human
male
middle aged
severity of illness index
single nucleotide polymorphism
tuberculosis
Adult
Alleles
Argentina
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Interferon-gamma
Interleukin-17
Male
Middle Aged
Polymorphism, Single Nucleotide
Severity of Illness Index
Tuberculosis
Rolandelli, A.
Del Pino, R.E.H.
Pellegrini, J.M.
Tateosian, N.L.
Amiano, N.O.
De La Barrera, S.
Casco, N.
Gutiérrez, M.
Palmero, D.J.
García, V.E.
The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina
topic_facet gamma interferon
IL17A protein, human
interleukin 17
adult
allele
Argentina
blood
female
gene frequency
genetic predisposition
genetics
genotype
human
male
middle aged
severity of illness index
single nucleotide polymorphism
tuberculosis
Adult
Alleles
Argentina
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Interferon-gamma
Interleukin-17
Male
Middle Aged
Polymorphism, Single Nucleotide
Severity of Illness Index
Tuberculosis
description Mycobacterium tuberculosis (Mtb) causes nearly 10 millions of new tuberculosis disease cases annually. However, most individuals exposed to Mtb do not develop tuberculosis, suggesting the influence of a human genetic component. Here, we investigated the association of the rs2275913 SNP (G → A) from IL-17A and tuberculosis in Argentina by a case-control study. Furthermore, we evaluated in vitro the functional relevance of this SNP during the immune response of the host against Mtb and analyzed its impact on clinical parameters of the disease. We found an association between the AA genotype and tuberculosis resistance. Additionally, within the healthy donors population, AA cells stimulated with a Mtb lysate (Mtb-Ag) produced the highest amounts of IL-17A and IFN-γ, which further support the genetic evidence found. In contrast, within the tuberculosis patients population, AA Mtb-Ag stimulated cells showed the lowest immunological parameters and we evidenced an association between the AA genotype and clinical parameters of disease severity, such as severe radiological lesions and higher bacilli burden in sputum. Overall, our findings demonstrated that the AA genotype from the IL-17A rs2275913 SNP is positively associated with protection to active tuberculosis but related to higher disease severity in the Argentinean population. © The Author(s) 2017.
format JOUR
author Rolandelli, A.
Del Pino, R.E.H.
Pellegrini, J.M.
Tateosian, N.L.
Amiano, N.O.
De La Barrera, S.
Casco, N.
Gutiérrez, M.
Palmero, D.J.
García, V.E.
author_facet Rolandelli, A.
Del Pino, R.E.H.
Pellegrini, J.M.
Tateosian, N.L.
Amiano, N.O.
De La Barrera, S.
Casco, N.
Gutiérrez, M.
Palmero, D.J.
García, V.E.
author_sort Rolandelli, A.
title The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina
title_short The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina
title_full The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina
title_fullStr The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina
title_full_unstemmed The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina
title_sort il-17a rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in argentina
url http://hdl.handle.net/20.500.12110/paper_20452322_v7_n_p_Rolandelli
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