On wakefulness fluctuations as a source of BOLD functional connectivity dynamics

Human brain dynamics and functional connectivity fluctuate over a range of temporal scales in coordination with internal states and environmental demands. However, the neurobiological significance and consequences of functional connectivity dynamics during rest have not yet been established. We show...

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Autores principales:	Haimovici, A., Tagliazucchi, E., Balenzuela, P., Laufs, H.
Formato:	JOUR
Materias:	oxygen blood cluster analysis electroencephalography female human male narcolepsy nerve cell network pathophysiology physiology REM sleep reproducibility wakefulness young adult Cluster Analysis Electroencephalography Female Humans Male Narcolepsy Nerve Net Oxygen Reproducibility of Results Sleep, REM Wakefulness Young Adult
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_20452322_v7_n1_p_Haimovici
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_20452322_v7_n1_p_Haimovici
record_format	dspace
spelling	todo:paper_20452322_v7_n1_p_Haimovici2023-10-03T16:38:19Z On wakefulness fluctuations as a source of BOLD functional connectivity dynamics Haimovici, A. Tagliazucchi, E. Balenzuela, P. Laufs, H. oxygen blood cluster analysis electroencephalography female human male narcolepsy nerve cell network pathophysiology physiology REM sleep reproducibility wakefulness young adult Cluster Analysis Electroencephalography Female Humans Male Narcolepsy Nerve Net Oxygen Reproducibility of Results Sleep, REM Wakefulness Young Adult Human brain dynamics and functional connectivity fluctuate over a range of temporal scales in coordination with internal states and environmental demands. However, the neurobiological significance and consequences of functional connectivity dynamics during rest have not yet been established. We show that the coarse-grained clustering of whole-brain dynamic connectivity measured with magnetic resonance imaging reveals discrete patterns (dynamic connectivity states) associated with wakefulness and sleep. We validate this using EEG in healthy subjects and patients with narcolepsy and by matching our results with previous findings in a large collaborative database. We also show that drowsiness may account for previous reports of metastable connectivity states associated with different levels of functional integration. This implies that future studies of transient functional connectivity must independently monitor wakefulness. We conclude that a possible neurobiological significance of dynamic connectivity states, computed at a sufficiently coarse temporal scale, is that of fluctuations in wakefulness. © 2017 The Author(s). JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_20452322_v7_n1_p_Haimovici
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	oxygen blood cluster analysis electroencephalography female human male narcolepsy nerve cell network pathophysiology physiology REM sleep reproducibility wakefulness young adult Cluster Analysis Electroencephalography Female Humans Male Narcolepsy Nerve Net Oxygen Reproducibility of Results Sleep, REM Wakefulness Young Adult
spellingShingle	oxygen blood cluster analysis electroencephalography female human male narcolepsy nerve cell network pathophysiology physiology REM sleep reproducibility wakefulness young adult Cluster Analysis Electroencephalography Female Humans Male Narcolepsy Nerve Net Oxygen Reproducibility of Results Sleep, REM Wakefulness Young Adult Haimovici, A. Tagliazucchi, E. Balenzuela, P. Laufs, H. On wakefulness fluctuations as a source of BOLD functional connectivity dynamics
topic_facet	oxygen blood cluster analysis electroencephalography female human male narcolepsy nerve cell network pathophysiology physiology REM sleep reproducibility wakefulness young adult Cluster Analysis Electroencephalography Female Humans Male Narcolepsy Nerve Net Oxygen Reproducibility of Results Sleep, REM Wakefulness Young Adult
description	Human brain dynamics and functional connectivity fluctuate over a range of temporal scales in coordination with internal states and environmental demands. However, the neurobiological significance and consequences of functional connectivity dynamics during rest have not yet been established. We show that the coarse-grained clustering of whole-brain dynamic connectivity measured with magnetic resonance imaging reveals discrete patterns (dynamic connectivity states) associated with wakefulness and sleep. We validate this using EEG in healthy subjects and patients with narcolepsy and by matching our results with previous findings in a large collaborative database. We also show that drowsiness may account for previous reports of metastable connectivity states associated with different levels of functional integration. This implies that future studies of transient functional connectivity must independently monitor wakefulness. We conclude that a possible neurobiological significance of dynamic connectivity states, computed at a sufficiently coarse temporal scale, is that of fluctuations in wakefulness. © 2017 The Author(s).
format	JOUR
author	Haimovici, A. Tagliazucchi, E. Balenzuela, P. Laufs, H.
author_facet	Haimovici, A. Tagliazucchi, E. Balenzuela, P. Laufs, H.
author_sort	Haimovici, A.
title	On wakefulness fluctuations as a source of BOLD functional connectivity dynamics
title_short	On wakefulness fluctuations as a source of BOLD functional connectivity dynamics
title_full	On wakefulness fluctuations as a source of BOLD functional connectivity dynamics
title_fullStr	On wakefulness fluctuations as a source of BOLD functional connectivity dynamics
title_full_unstemmed	On wakefulness fluctuations as a source of BOLD functional connectivity dynamics
title_sort	on wakefulness fluctuations as a source of bold functional connectivity dynamics
url	http://hdl.handle.net/20.500.12110/paper_20452322_v7_n1_p_Haimovici
work_keys_str_mv	AT haimovicia onwakefulnessfluctuationsasasourceofboldfunctionalconnectivitydynamics AT tagliazucchie onwakefulnessfluctuationsasasourceofboldfunctionalconnectivitydynamics AT balenzuelap onwakefulnessfluctuationsasasourceofboldfunctionalconnectivitydynamics AT laufsh onwakefulnessfluctuationsasasourceofboldfunctionalconnectivitydynamics
_version_	1807318772871069696

On wakefulness fluctuations as a source of BOLD functional connectivity dynamics

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