Novelty during a late postacquisition time window attenuates the persistence of fear memory

Learning to avoid threats in the environment is highly adaptive. However, sometimes a dysregulation of fear memories processing may underlie fear-related disorders. Despite recent advances, a major question of how to effectively attenuate persistent fear memories in a safe manner remains unresolved....

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Detalles Bibliográficos
Autores principales: Katche, C., Tomaiuolo, M., Dorman, G., Medina, J.H., Viola, H.
Formato: JOUR
Materias:
animal
avoidance behavior
fear
male
memory
rat
Wistar rat
Animals
Avoidance Learning
Fear
Male
Memory
Rats
Rats, Wistar
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_20452322_v6_n_p_Katche
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_20452322_v6_n_p_Katche
record_format dspace
spelling todo:paper_20452322_v6_n_p_Katche2023-10-03T16:38:14Z Novelty during a late postacquisition time window attenuates the persistence of fear memory Katche, C. Tomaiuolo, M. Dorman, G. Medina, J.H. Viola, H. animal avoidance behavior fear male memory rat Wistar rat Animals Avoidance Learning Fear Male Memory Rats Rats, Wistar Learning to avoid threats in the environment is highly adaptive. However, sometimes a dysregulation of fear memories processing may underlie fear-related disorders. Despite recent advances, a major question of how to effectively attenuate persistent fear memories in a safe manner remains unresolved. Here we show experiments employing a behavioural tool to target a specific time window after training to limit the persistence of a fear memory in rats. We observed that exposure to a novel environment 11 h after an inhibitory avoidance (IA) training that induces a long-lasting memory, attenuates the durability of IA memory but not its formation. This effect is time-restricted and not seen when the environment is familiar. In addition, novelty-induced attenuation of IA memory durability is prevented by the intrahippocampal infusion of the CaMKs inhibitor KN-93. This new behavioural approach which targets a specific time window during late memory consolidation, might represent a new tool for reducing the durability of persistent fear memories. © The Author(s) 2016. Fil:Katche, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_20452322_v6_n_p_Katche
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic animal
avoidance behavior
fear
male
memory
rat
Wistar rat
Animals
Avoidance Learning
Fear
Male
Memory
Rats
Rats, Wistar
spellingShingle animal
avoidance behavior
fear
male
memory
rat
Wistar rat
Animals
Avoidance Learning
Fear
Male
Memory
Rats
Rats, Wistar
Katche, C.
Tomaiuolo, M.
Dorman, G.
Medina, J.H.
Viola, H.
Novelty during a late postacquisition time window attenuates the persistence of fear memory
topic_facet animal
avoidance behavior
fear
male
memory
rat
Wistar rat
Animals
Avoidance Learning
Fear
Male
Memory
Rats
Rats, Wistar
description Learning to avoid threats in the environment is highly adaptive. However, sometimes a dysregulation of fear memories processing may underlie fear-related disorders. Despite recent advances, a major question of how to effectively attenuate persistent fear memories in a safe manner remains unresolved. Here we show experiments employing a behavioural tool to target a specific time window after training to limit the persistence of a fear memory in rats. We observed that exposure to a novel environment 11 h after an inhibitory avoidance (IA) training that induces a long-lasting memory, attenuates the durability of IA memory but not its formation. This effect is time-restricted and not seen when the environment is familiar. In addition, novelty-induced attenuation of IA memory durability is prevented by the intrahippocampal infusion of the CaMKs inhibitor KN-93. This new behavioural approach which targets a specific time window during late memory consolidation, might represent a new tool for reducing the durability of persistent fear memories. © The Author(s) 2016.
format JOUR
author Katche, C.
Tomaiuolo, M.
Dorman, G.
Medina, J.H.
Viola, H.
author_facet Katche, C.
Tomaiuolo, M.
Dorman, G.
Medina, J.H.
Viola, H.
author_sort Katche, C.
title Novelty during a late postacquisition time window attenuates the persistence of fear memory
title_short Novelty during a late postacquisition time window attenuates the persistence of fear memory
title_full Novelty during a late postacquisition time window attenuates the persistence of fear memory
title_fullStr Novelty during a late postacquisition time window attenuates the persistence of fear memory
title_full_unstemmed Novelty during a late postacquisition time window attenuates the persistence of fear memory
title_sort novelty during a late postacquisition time window attenuates the persistence of fear memory
url http://hdl.handle.net/20.500.12110/paper_20452322_v6_n_p_Katche
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AT tomaiuolom noveltyduringalatepostacquisitiontimewindowattenuatesthepersistenceoffearmemory
AT dormang noveltyduringalatepostacquisitiontimewindowattenuatesthepersistenceoffearmemory
AT medinajh noveltyduringalatepostacquisitiontimewindowattenuatesthepersistenceoffearmemory
AT violah noveltyduringalatepostacquisitiontimewindowattenuatesthepersistenceoffearmemory
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