Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles
The possibility of combining more than one stimulus-responsive property into a single material holds interesting potential for the creation of adaptive devices to be used in diverse fields such as drug delivery, nanomedicine and tissue engineering. This paper describes a novel material based on ther...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_20403364_v10_n3_p1189_Giussi |
| Aporte de: |
| id |
todo:paper_20403364_v10_n3_p1189_Giussi |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_20403364_v10_n3_p1189_Giussi2023-10-03T16:37:44Z Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles Giussi, J.M. Von Bilderling, C. Alarcón, E. Pietrasanta, L.I. Hernandez, R. Del Real, R.P. Vázquez, M. Mijangos, C. Cortez, M.L. Azzaroni, O. Acrylics Atom transfer radical polymerization Cell culture Free radical reactions Iron compounds Magnetism Medical nanotechnology Nanomagnetics Nanoparticles Nanostructures Scaffolds (biology) Stiffness Temperature Tissue engineering Anodized aluminum oxide Human body temperature Magnetic nano-particles Nanostructured systems Superparamagnetic nanoparticles Surface initiated-atom transfer radical polymerization Temperature variation Volume phase transition Drug delivery The possibility of combining more than one stimulus-responsive property into a single material holds interesting potential for the creation of adaptive devices to be used in diverse fields such as drug delivery, nanomedicine and tissue engineering. This paper describes a novel material based on thermo-responsive PNIPAm nanopillars with amplified surface properties through the incorporation of Fe3O4 nanoparticles. The incorporation of magnetic nanoparticles into the nanopillars, prepared via surface-initiated atom-transfer radical polymerization in anodized aluminum oxide templates, sharply increased their stiffness and hydrophobicity when increasing the temperature above the volume phase transition temperature. Furthermore, their magnetic response turned out to be proportional to the amount of the incorporated nanoparticles. The possibility of sharply increasing the stiffness with a temperature variation close to the human body temperature paves the way to the application of these substrates as "smart" scaffolds for cell culture. Additionally, the presence of superparamagnetic nanoparticles in the nanopillars offers the possibility of using these nanostructured systems for magnetic hyperthermia. © 2018 The Royal Society of Chemistry. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_20403364_v10_n3_p1189_Giussi |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Acrylics Atom transfer radical polymerization Cell culture Free radical reactions Iron compounds Magnetism Medical nanotechnology Nanomagnetics Nanoparticles Nanostructures Scaffolds (biology) Stiffness Temperature Tissue engineering Anodized aluminum oxide Human body temperature Magnetic nano-particles Nanostructured systems Superparamagnetic nanoparticles Surface initiated-atom transfer radical polymerization Temperature variation Volume phase transition Drug delivery |
| spellingShingle |
Acrylics Atom transfer radical polymerization Cell culture Free radical reactions Iron compounds Magnetism Medical nanotechnology Nanomagnetics Nanoparticles Nanostructures Scaffolds (biology) Stiffness Temperature Tissue engineering Anodized aluminum oxide Human body temperature Magnetic nano-particles Nanostructured systems Superparamagnetic nanoparticles Surface initiated-atom transfer radical polymerization Temperature variation Volume phase transition Drug delivery Giussi, J.M. Von Bilderling, C. Alarcón, E. Pietrasanta, L.I. Hernandez, R. Del Real, R.P. Vázquez, M. Mijangos, C. Cortez, M.L. Azzaroni, O. Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles |
| topic_facet |
Acrylics Atom transfer radical polymerization Cell culture Free radical reactions Iron compounds Magnetism Medical nanotechnology Nanomagnetics Nanoparticles Nanostructures Scaffolds (biology) Stiffness Temperature Tissue engineering Anodized aluminum oxide Human body temperature Magnetic nano-particles Nanostructured systems Superparamagnetic nanoparticles Surface initiated-atom transfer radical polymerization Temperature variation Volume phase transition Drug delivery |
| description |
The possibility of combining more than one stimulus-responsive property into a single material holds interesting potential for the creation of adaptive devices to be used in diverse fields such as drug delivery, nanomedicine and tissue engineering. This paper describes a novel material based on thermo-responsive PNIPAm nanopillars with amplified surface properties through the incorporation of Fe3O4 nanoparticles. The incorporation of magnetic nanoparticles into the nanopillars, prepared via surface-initiated atom-transfer radical polymerization in anodized aluminum oxide templates, sharply increased their stiffness and hydrophobicity when increasing the temperature above the volume phase transition temperature. Furthermore, their magnetic response turned out to be proportional to the amount of the incorporated nanoparticles. The possibility of sharply increasing the stiffness with a temperature variation close to the human body temperature paves the way to the application of these substrates as "smart" scaffolds for cell culture. Additionally, the presence of superparamagnetic nanoparticles in the nanopillars offers the possibility of using these nanostructured systems for magnetic hyperthermia. © 2018 The Royal Society of Chemistry. |
| format |
JOUR |
| author |
Giussi, J.M. Von Bilderling, C. Alarcón, E. Pietrasanta, L.I. Hernandez, R. Del Real, R.P. Vázquez, M. Mijangos, C. Cortez, M.L. Azzaroni, O. |
| author_facet |
Giussi, J.M. Von Bilderling, C. Alarcón, E. Pietrasanta, L.I. Hernandez, R. Del Real, R.P. Vázquez, M. Mijangos, C. Cortez, M.L. Azzaroni, O. |
| author_sort |
Giussi, J.M. |
| title |
Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles |
| title_short |
Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles |
| title_full |
Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles |
| title_fullStr |
Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles |
| title_full_unstemmed |
Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles |
| title_sort |
thermo-responsive pnipam nanopillars displaying amplified responsiveness through the incorporation of nanoparticles |
| url |
http://hdl.handle.net/20.500.12110/paper_20403364_v10_n3_p1189_Giussi |
| work_keys_str_mv |
AT giussijm thermoresponsivepnipamnanopillarsdisplayingamplifiedresponsivenessthroughtheincorporationofnanoparticles AT vonbilderlingc thermoresponsivepnipamnanopillarsdisplayingamplifiedresponsivenessthroughtheincorporationofnanoparticles AT alarcone thermoresponsivepnipamnanopillarsdisplayingamplifiedresponsivenessthroughtheincorporationofnanoparticles AT pietrasantali thermoresponsivepnipamnanopillarsdisplayingamplifiedresponsivenessthroughtheincorporationofnanoparticles AT hernandezr thermoresponsivepnipamnanopillarsdisplayingamplifiedresponsivenessthroughtheincorporationofnanoparticles AT delrealrp thermoresponsivepnipamnanopillarsdisplayingamplifiedresponsivenessthroughtheincorporationofnanoparticles AT vazquezm thermoresponsivepnipamnanopillarsdisplayingamplifiedresponsivenessthroughtheincorporationofnanoparticles AT mijangosc thermoresponsivepnipamnanopillarsdisplayingamplifiedresponsivenessthroughtheincorporationofnanoparticles AT cortezml thermoresponsivepnipamnanopillarsdisplayingamplifiedresponsivenessthroughtheincorporationofnanoparticles AT azzaronio thermoresponsivepnipamnanopillarsdisplayingamplifiedresponsivenessthroughtheincorporationofnanoparticles |
| _version_ |
1807322959432384512 |