Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse
This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using modulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to...
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_19840659_v8_n3_p162_Urbano |
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todo:paper_19840659_v8_n3_p162_Urbano2023-10-03T16:37:28Z Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse Urbano, F.J. Bisagno, V. González, B. Rivero-Echeto, M.C. MuñIz, J.A. Luster, B. D’Onofrio, S. Mahaffey, S. Garcia-Rill, E. Amphetamine Cocaine Dopamine Nicotine P/Q-type calciumchannels T-type calciumchannels calcium channel cocaine nicotine psychostimulant agent behavior human locomotion membrane potential pedunculopontine tegmental nucleus physiology Review sleep arousal disorder sleep deprivation This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using modulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to be involved in the animal’s voluntary search for psychostimulants. Every PPN neuron is known to generate gamma band oscillations. Voltage-gated calcium channels are key elements in the generation and maintenance of gamma band activity of PPN neurons. Calcium channels are also key elements mediating psychostimulant-induced alterations in the thalamic targets of PPN output. Thus, the PPN is a key substrate for maintaining arousal and REM sleep, but also in modulating psychostimulant self-administration. © 2015 Brazilian Association of Sleep. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19840659_v8_n3_p162_Urbano |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Amphetamine Cocaine Dopamine Nicotine P/Q-type calciumchannels T-type calciumchannels calcium channel cocaine nicotine psychostimulant agent behavior human locomotion membrane potential pedunculopontine tegmental nucleus physiology Review sleep arousal disorder sleep deprivation |
| spellingShingle |
Amphetamine Cocaine Dopamine Nicotine P/Q-type calciumchannels T-type calciumchannels calcium channel cocaine nicotine psychostimulant agent behavior human locomotion membrane potential pedunculopontine tegmental nucleus physiology Review sleep arousal disorder sleep deprivation Urbano, F.J. Bisagno, V. González, B. Rivero-Echeto, M.C. MuñIz, J.A. Luster, B. D’Onofrio, S. Mahaffey, S. Garcia-Rill, E. Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse |
| topic_facet |
Amphetamine Cocaine Dopamine Nicotine P/Q-type calciumchannels T-type calciumchannels calcium channel cocaine nicotine psychostimulant agent behavior human locomotion membrane potential pedunculopontine tegmental nucleus physiology Review sleep arousal disorder sleep deprivation |
| description |
This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using modulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to be involved in the animal’s voluntary search for psychostimulants. Every PPN neuron is known to generate gamma band oscillations. Voltage-gated calcium channels are key elements in the generation and maintenance of gamma band activity of PPN neurons. Calcium channels are also key elements mediating psychostimulant-induced alterations in the thalamic targets of PPN output. Thus, the PPN is a key substrate for maintaining arousal and REM sleep, but also in modulating psychostimulant self-administration. © 2015 Brazilian Association of Sleep. |
| format |
JOUR |
| author |
Urbano, F.J. Bisagno, V. González, B. Rivero-Echeto, M.C. MuñIz, J.A. Luster, B. D’Onofrio, S. Mahaffey, S. Garcia-Rill, E. |
| author_facet |
Urbano, F.J. Bisagno, V. González, B. Rivero-Echeto, M.C. MuñIz, J.A. Luster, B. D’Onofrio, S. Mahaffey, S. Garcia-Rill, E. |
| author_sort |
Urbano, F.J. |
| title |
Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse |
| title_short |
Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse |
| title_full |
Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse |
| title_fullStr |
Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse |
| title_full_unstemmed |
Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse |
| title_sort |
pedunculopontine arousal system(ft physiology—effects of psychostimulant abuse |
| url |
http://hdl.handle.net/20.500.12110/paper_19840659_v8_n3_p162_Urbano |
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