Pedunculopontine arousal system physiology - Deep brain stimulation (DBS)

This review describes the wake/sleep symptoms present in Parkinson's disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target...

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Detalles Bibliográficos
Autores principales: Garcia-Rill, E., Luster, B., D'Onofrio, S., Mahaffey, S., Bisagno, V., Urbano, F.J.
Formato: JOUR
Materias:
Basal forebrain
Calcium channels
Gamma band activity
Lateral hypothalamus
Orexin
Tuberomammillary
brain depth stimulation
evoked brain stem auditory response
human
insomnia
outcome assessment
Parkinson disease
pedunculopontine tegmental nucleus
Review
sleep arousal disorder
subthalamic nucleus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19840659_v8_n3_p153_GarciaRill
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:This review describes the wake/sleep symptoms present in Parkinson's disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for deep brain stimulation in the treatment of gait and postural deficits in Parkinson's disease. A greater understanding of the physiology of the target nuclei within the brainstem and basal ganglia, amassed over the past decades, has enabled increasingly better patient outcomes from deep brain stimulation for movement disorders. © 2015 Brazilian Association of Sleep.

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