Delayed coupling theory of vertebrate segmentation
Rhythmic and sequential subdivision of the elongating vertebrate embryonic body axis into morphological somites is controlled by an oscillating multicellular genetic network termed the segmentation clock. This clock operates in the presomitic mesoderm (PSM), generating dynamic stripe patterns of osc...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_19552068_v3_n1_p55_Morelli |
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todo:paper_19552068_v3_n1_p55_Morelli2023-10-03T16:37:23Z Delayed coupling theory of vertebrate segmentation Morelli, L.G. Ares, S. Herrgen, L. Schröter, C. Jülicher, F. Oates, A.C. Vertebrata Rhythmic and sequential subdivision of the elongating vertebrate embryonic body axis into morphological somites is controlled by an oscillating multicellular genetic network termed the segmentation clock. This clock operates in the presomitic mesoderm (PSM), generating dynamic stripe patterns of oscillatory gene-expression across the field of PSM cells. How these spatial patterns, the clock's collective period, and the underlying cellular-level interactions are related is not understood. A theory encompassing temporal and spatial domains of local and collective aspects of the system is essential to tackle these questions. Our delayed coupling theory achieves this by representing the PSM as an array of phase oscillators, combining four key elements: a frequency profile of oscillators slowing across the PSM; coupling between neighboring oscillators; delay in coupling; and a moving boundary describing embryonic axis elongation. This theory predicts that the segmentation clock's collective period depends on delayed coupling. We derive an expression for pattern wavelength across the PSM and show how this can be used to fit dynamic wildtype gene-expression patterns, revealing the quantitative values of parameters controlling spatial and temporal organization of the oscillators in the system. Our theory can be used to analyze experimental perturbations, thereby identifying roles of genes involved in segmentation. © HFSP Publishing. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19552068_v3_n1_p55_Morelli |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Vertebrata |
| spellingShingle |
Vertebrata Morelli, L.G. Ares, S. Herrgen, L. Schröter, C. Jülicher, F. Oates, A.C. Delayed coupling theory of vertebrate segmentation |
| topic_facet |
Vertebrata |
| description |
Rhythmic and sequential subdivision of the elongating vertebrate embryonic body axis into morphological somites is controlled by an oscillating multicellular genetic network termed the segmentation clock. This clock operates in the presomitic mesoderm (PSM), generating dynamic stripe patterns of oscillatory gene-expression across the field of PSM cells. How these spatial patterns, the clock's collective period, and the underlying cellular-level interactions are related is not understood. A theory encompassing temporal and spatial domains of local and collective aspects of the system is essential to tackle these questions. Our delayed coupling theory achieves this by representing the PSM as an array of phase oscillators, combining four key elements: a frequency profile of oscillators slowing across the PSM; coupling between neighboring oscillators; delay in coupling; and a moving boundary describing embryonic axis elongation. This theory predicts that the segmentation clock's collective period depends on delayed coupling. We derive an expression for pattern wavelength across the PSM and show how this can be used to fit dynamic wildtype gene-expression patterns, revealing the quantitative values of parameters controlling spatial and temporal organization of the oscillators in the system. Our theory can be used to analyze experimental perturbations, thereby identifying roles of genes involved in segmentation. © HFSP Publishing. |
| format |
JOUR |
| author |
Morelli, L.G. Ares, S. Herrgen, L. Schröter, C. Jülicher, F. Oates, A.C. |
| author_facet |
Morelli, L.G. Ares, S. Herrgen, L. Schröter, C. Jülicher, F. Oates, A.C. |
| author_sort |
Morelli, L.G. |
| title |
Delayed coupling theory of vertebrate segmentation |
| title_short |
Delayed coupling theory of vertebrate segmentation |
| title_full |
Delayed coupling theory of vertebrate segmentation |
| title_fullStr |
Delayed coupling theory of vertebrate segmentation |
| title_full_unstemmed |
Delayed coupling theory of vertebrate segmentation |
| title_sort |
delayed coupling theory of vertebrate segmentation |
| url |
http://hdl.handle.net/20.500.12110/paper_19552068_v3_n1_p55_Morelli |
| work_keys_str_mv |
AT morellilg delayedcouplingtheoryofvertebratesegmentation AT aress delayedcouplingtheoryofvertebratesegmentation AT herrgenl delayedcouplingtheoryofvertebratesegmentation AT schroterc delayedcouplingtheoryofvertebratesegmentation AT julicherf delayedcouplingtheoryofvertebratesegmentation AT oatesac delayedcouplingtheoryofvertebratesegmentation |
| _version_ |
1807316577994932224 |