Load-induced modulation of signal transduction networks
Biological signal transduction networks are commonly viewed as circuits that pass along information - in the process amplifying signals, enhancing sensitivity, or performing other signal-processing tasks - to transcriptional and other components. Here, we report on a "reverse-causality" ph...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_19450877_v4_n194_p_Jiang |
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todo:paper_19450877_v4_n194_p_Jiang2023-10-03T16:37:05Z Load-induced modulation of signal transduction networks Jiang, P. Ventura, A.C. Sontag, E.D. Merajver, S.D. Ninfa, A.J. Del Vecchio, D. article enzyme activity information processing mathematical model modulation priority journal signal processing signal transduction allosterism biological model Escherichia coli feedback system metabolism physiology systems biology time enzyme nitrogen regulatory protein nucleotidyltransferase regulatory protein uridylyltransferase Allosteric Regulation Enzymes Escherichia coli Feedback, Physiological Models, Biological Nucleotidyltransferases PII Nitrogen Regulatory Proteins Signal Transduction Systems Biology Time Factors Biological signal transduction networks are commonly viewed as circuits that pass along information - in the process amplifying signals, enhancing sensitivity, or performing other signal-processing tasks - to transcriptional and other components. Here, we report on a "reverse-causality" phenomenon, which we call load-induced modulation. Through a combination of analytical and experimental tools, we discovered that signaling was modulated, in a surprising way, by downstream targets that receive the signal and, in doing so, apply what in physics is called a load. Specifically, we found that non-intuitivechanges in response dynamics occurred for a covalent modification cycle when load was present.Loading altered the response time of a system, depending on whether the activity of one of the enzymeswas maximal and the other was operating at its minimal rate or whether both enzymes were operating atsubmaximal rates. These two conditions, which we call "limit regime" and "intermediate regime," wereassociated with increased or decreased response times, respectively. The bandwidth, the range of frequencyin which the system can process information, decreased in the presence of load, suggesting thatdownstream targets participate in establishing a balance between noise-filtering capabilities and a circuit'sability to process high-frequency stimulation. Nodes in a signaling network are not independentrelay devices, but rather are modulated by their downstream targets. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19450877_v4_n194_p_Jiang |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
article enzyme activity information processing mathematical model modulation priority journal signal processing signal transduction allosterism biological model Escherichia coli feedback system metabolism physiology systems biology time enzyme nitrogen regulatory protein nucleotidyltransferase regulatory protein uridylyltransferase Allosteric Regulation Enzymes Escherichia coli Feedback, Physiological Models, Biological Nucleotidyltransferases PII Nitrogen Regulatory Proteins Signal Transduction Systems Biology Time Factors |
| spellingShingle |
article enzyme activity information processing mathematical model modulation priority journal signal processing signal transduction allosterism biological model Escherichia coli feedback system metabolism physiology systems biology time enzyme nitrogen regulatory protein nucleotidyltransferase regulatory protein uridylyltransferase Allosteric Regulation Enzymes Escherichia coli Feedback, Physiological Models, Biological Nucleotidyltransferases PII Nitrogen Regulatory Proteins Signal Transduction Systems Biology Time Factors Jiang, P. Ventura, A.C. Sontag, E.D. Merajver, S.D. Ninfa, A.J. Del Vecchio, D. Load-induced modulation of signal transduction networks |
| topic_facet |
article enzyme activity information processing mathematical model modulation priority journal signal processing signal transduction allosterism biological model Escherichia coli feedback system metabolism physiology systems biology time enzyme nitrogen regulatory protein nucleotidyltransferase regulatory protein uridylyltransferase Allosteric Regulation Enzymes Escherichia coli Feedback, Physiological Models, Biological Nucleotidyltransferases PII Nitrogen Regulatory Proteins Signal Transduction Systems Biology Time Factors |
| description |
Biological signal transduction networks are commonly viewed as circuits that pass along information - in the process amplifying signals, enhancing sensitivity, or performing other signal-processing tasks - to transcriptional and other components. Here, we report on a "reverse-causality" phenomenon, which we call load-induced modulation. Through a combination of analytical and experimental tools, we discovered that signaling was modulated, in a surprising way, by downstream targets that receive the signal and, in doing so, apply what in physics is called a load. Specifically, we found that non-intuitivechanges in response dynamics occurred for a covalent modification cycle when load was present.Loading altered the response time of a system, depending on whether the activity of one of the enzymeswas maximal and the other was operating at its minimal rate or whether both enzymes were operating atsubmaximal rates. These two conditions, which we call "limit regime" and "intermediate regime," wereassociated with increased or decreased response times, respectively. The bandwidth, the range of frequencyin which the system can process information, decreased in the presence of load, suggesting thatdownstream targets participate in establishing a balance between noise-filtering capabilities and a circuit'sability to process high-frequency stimulation. Nodes in a signaling network are not independentrelay devices, but rather are modulated by their downstream targets. |
| format |
JOUR |
| author |
Jiang, P. Ventura, A.C. Sontag, E.D. Merajver, S.D. Ninfa, A.J. Del Vecchio, D. |
| author_facet |
Jiang, P. Ventura, A.C. Sontag, E.D. Merajver, S.D. Ninfa, A.J. Del Vecchio, D. |
| author_sort |
Jiang, P. |
| title |
Load-induced modulation of signal transduction networks |
| title_short |
Load-induced modulation of signal transduction networks |
| title_full |
Load-induced modulation of signal transduction networks |
| title_fullStr |
Load-induced modulation of signal transduction networks |
| title_full_unstemmed |
Load-induced modulation of signal transduction networks |
| title_sort |
load-induced modulation of signal transduction networks |
| url |
http://hdl.handle.net/20.500.12110/paper_19450877_v4_n194_p_Jiang |
| work_keys_str_mv |
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| _version_ |
1807318073113313280 |