Immunomodulatory effects of chemokines during the early implantation window

Successful implantation requires a functionally normal embryo at the blastocyst stage and a receptive endometrium as well as adequate communication between them throughout the implantation process. This cross-talk is highly regulated by a number of different kinds of molecules. Particularly, chemoki...

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Autores principales: Fraccaroli, L., Alfieri, J., Leiros, C.P., Ramhorst, R.
Formato: JOUR
Materias:
Chemokines
Pregnancy
Recurrent spontaneous abortions
Review
Tolerance
chemokine
immunologic factor
RANTES
cytology
drug effect
endometrium
female
fetomaternal transfusion
histocompatibility
human
immunology
metabolism
nidation
pregnancy
recurrent abortion
review
T lymphocyte
Abortion, Habitual
Chemokine CCL5
Embryo Implantation
Endometrium
Female
Histocompatibility, Maternal-Fetal
Humans
Immunologic Factors
Maternal-Fetal Exchange
T-Lymphocytes
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19450494_v1E_n1_p288_Fraccaroli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_19450494_v1E_n1_p288_Fraccaroli
record_format dspace
spelling todo:paper_19450494_v1E_n1_p288_Fraccaroli2023-10-03T16:37:04Z Immunomodulatory effects of chemokines during the early implantation window Fraccaroli, L. Alfieri, J. Leiros, C.P. Ramhorst, R. Chemokines Pregnancy Recurrent spontaneous abortions Review Tolerance chemokine immunologic factor RANTES cytology drug effect endometrium female fetomaternal transfusion histocompatibility human immunology metabolism nidation pregnancy recurrent abortion review T lymphocyte Abortion, Habitual Chemokine CCL5 Chemokines Embryo Implantation Endometrium Female Histocompatibility, Maternal-Fetal Humans Immunologic Factors Maternal-Fetal Exchange Pregnancy T-Lymphocytes Successful implantation requires a functionally normal embryo at the blastocyst stage and a receptive endometrium as well as adequate communication between them throughout the implantation process. This cross-talk is highly regulated by a number of different kinds of molecules. Particularly, chemokines-small polypeptides that attract specific leukocyte subsets by binding to cellsurface receptors- are also required to maintain immuneprivileged sites as the feto-maternal interface. Chemokines expression involves an interdependent network with the absence of a single chemokine affecting the expression of multiple other chemokines, we have chosen to focus on just two representative examples: RANTES (regulated on normal T cell expressed and secreted) and MCP-1 (Monocyte chemo-attractant protein). Here, we present updated information on their expression levels and regulation on three different levels: 1) systemic effects on maternal allogeneic response; 2) local effects on endometrial cells; and 3) during an early stage of the feto-maternal dialogue. For each of the three levels, we analyzed data from both fertile women and patients having experienced recurrent spontaneous abortions as representative of physiological and pathological situations respectively. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19450494_v1E_n1_p288_Fraccaroli
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Chemokines
Pregnancy
Recurrent spontaneous abortions
Review
Tolerance
chemokine
immunologic factor
RANTES
cytology
drug effect
endometrium
female
fetomaternal transfusion
histocompatibility
human
immunology
metabolism
nidation
pregnancy
recurrent abortion
review
T lymphocyte
Abortion, Habitual
Chemokine CCL5
Chemokines
Embryo Implantation
Endometrium
Female
Histocompatibility, Maternal-Fetal
Humans
Immunologic Factors
Maternal-Fetal Exchange
Pregnancy
T-Lymphocytes
spellingShingle Chemokines
Pregnancy
Recurrent spontaneous abortions
Review
Tolerance
chemokine
immunologic factor
RANTES
cytology
drug effect
endometrium
female
fetomaternal transfusion
histocompatibility
human
immunology
metabolism
nidation
pregnancy
recurrent abortion
review
T lymphocyte
Abortion, Habitual
Chemokine CCL5
Chemokines
Embryo Implantation
Endometrium
Female
Histocompatibility, Maternal-Fetal
Humans
Immunologic Factors
Maternal-Fetal Exchange
Pregnancy
T-Lymphocytes
Fraccaroli, L.
Alfieri, J.
Leiros, C.P.
Ramhorst, R.
Immunomodulatory effects of chemokines during the early implantation window
topic_facet Chemokines
Pregnancy
Recurrent spontaneous abortions
Review
Tolerance
chemokine
immunologic factor
RANTES
cytology
drug effect
endometrium
female
fetomaternal transfusion
histocompatibility
human
immunology
metabolism
nidation
pregnancy
recurrent abortion
review
T lymphocyte
Abortion, Habitual
Chemokine CCL5
Chemokines
Embryo Implantation
Endometrium
Female
Histocompatibility, Maternal-Fetal
Humans
Immunologic Factors
Maternal-Fetal Exchange
Pregnancy
T-Lymphocytes
description Successful implantation requires a functionally normal embryo at the blastocyst stage and a receptive endometrium as well as adequate communication between them throughout the implantation process. This cross-talk is highly regulated by a number of different kinds of molecules. Particularly, chemokines-small polypeptides that attract specific leukocyte subsets by binding to cellsurface receptors- are also required to maintain immuneprivileged sites as the feto-maternal interface. Chemokines expression involves an interdependent network with the absence of a single chemokine affecting the expression of multiple other chemokines, we have chosen to focus on just two representative examples: RANTES (regulated on normal T cell expressed and secreted) and MCP-1 (Monocyte chemo-attractant protein). Here, we present updated information on their expression levels and regulation on three different levels: 1) systemic effects on maternal allogeneic response; 2) local effects on endometrial cells; and 3) during an early stage of the feto-maternal dialogue. For each of the three levels, we analyzed data from both fertile women and patients having experienced recurrent spontaneous abortions as representative of physiological and pathological situations respectively.
format JOUR
author Fraccaroli, L.
Alfieri, J.
Leiros, C.P.
Ramhorst, R.
author_facet Fraccaroli, L.
Alfieri, J.
Leiros, C.P.
Ramhorst, R.
author_sort Fraccaroli, L.
title Immunomodulatory effects of chemokines during the early implantation window
title_short Immunomodulatory effects of chemokines during the early implantation window
title_full Immunomodulatory effects of chemokines during the early implantation window
title_fullStr Immunomodulatory effects of chemokines during the early implantation window
title_full_unstemmed Immunomodulatory effects of chemokines during the early implantation window
title_sort immunomodulatory effects of chemokines during the early implantation window
url http://hdl.handle.net/20.500.12110/paper_19450494_v1E_n1_p288_Fraccaroli
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AT alfierij immunomodulatoryeffectsofchemokinesduringtheearlyimplantationwindow
AT leiroscp immunomodulatoryeffectsofchemokinesduringtheearlyimplantationwindow
AT ramhorstr immunomodulatoryeffectsofchemokinesduringtheearlyimplantationwindow
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