Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation

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Regulation of alternative splicing is coupled to transcription quality, the polymerase elongation rate being an important factor in modulating splicing choices. In a recently published work, we provide evidence that intragenic histone acetylation patterns can be affected by neural cell excitation in...

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Detalles Bibliográficos
Autores principales: Schor, I.E., Kornblihtt, A.R.
Formato: JOUR
Materias:
Alternative splicing
Chromatin
Histone acetylation
NCAM
Neuronal excitation
Structure
Transcriptional elongation
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19420889_v2_n4_p341_Schor
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_19420889_v2_n4_p341_Schor
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spelling todo:paper_19420889_v2_n4_p341_Schor2023-10-03T16:36:56Z Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation Schor, I.E. Kornblihtt, A.R. Alternative splicing Chromatin Histone acetylation NCAM Neuronal excitation Structure Transcriptional elongation Regulation of alternative splicing is coupled to transcription quality, the polymerase elongation rate being an important factor in modulating splicing choices. In a recently published work, we provide evidence that intragenic histone acetylation patterns can be affected by neural cell excitation in order to regulate alternative splicing of the neural cell adhesion molecule (NCAM) mRNA. This example illustrates how an extracellular stimulus can influence transcription-coupled alternative splicing, strengthening the link between chromatin structure, transcriptional elongation and mRNA processing. ©2009 Landes Bioscience. Fil:Schor, I.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19420889_v2_n4_p341_Schor
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Alternative splicing
Chromatin
Histone acetylation
NCAM
Neuronal excitation
Structure
Transcriptional elongation
spellingShingle Alternative splicing
Chromatin
Histone acetylation
NCAM
Neuronal excitation
Structure
Transcriptional elongation
Schor, I.E.
Kornblihtt, A.R.
Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
topic_facet Alternative splicing
Chromatin
Histone acetylation
NCAM
Neuronal excitation
Structure
Transcriptional elongation
description Regulation of alternative splicing is coupled to transcription quality, the polymerase elongation rate being an important factor in modulating splicing choices. In a recently published work, we provide evidence that intragenic histone acetylation patterns can be affected by neural cell excitation in order to regulate alternative splicing of the neural cell adhesion molecule (NCAM) mRNA. This example illustrates how an extracellular stimulus can influence transcription-coupled alternative splicing, strengthening the link between chromatin structure, transcriptional elongation and mRNA processing. ©2009 Landes Bioscience.
format JOUR
author Schor, I.E.
Kornblihtt, A.R.
author_facet Schor, I.E.
Kornblihtt, A.R.
author_sort Schor, I.E.
title Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
title_short Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
title_full Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
title_fullStr Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
title_full_unstemmed Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
title_sort playing inside the genes: intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
url http://hdl.handle.net/20.500.12110/paper_19420889_v2_n4_p341_Schor
work_keys_str_mv AT schorie playinginsidethegenesintragenichistoneacetylationaftermembranedepolarizationofneuralcellsopensapathforalternativesplicingregulation
AT kornblihttar playinginsidethegenesintragenichistoneacetylationaftermembranedepolarizationofneuralcellsopensapathforalternativesplicingregulation
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