Beating the odds: Sustained Chagas disease vector control in remote indigenous communities of the Argentine Chaco over a seven-year period
BACKGROUND: Rapid reinfestation of insecticide-treated dwellings hamper the sustained elimination of Triatoma infestans, the main vector of Chagas disease in the Gran Chaco region. We conducted a seven-year longitudinal study including community-wide spraying with pyrethroid insecticides combined wi...
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todo:paper_19352735_v12_n10_pe0006804_Gaspe2023-10-03T16:36:20Z Beating the odds: Sustained Chagas disease vector control in remote indigenous communities of the Argentine Chaco over a seven-year period Gaspe, M.S. Provecho, Y.M. Fernández, M.P. Vassena, C.V. Santo Orihuela, P.L. Gürtler, R.E. insecticide pyrethroid administration and dosage adolescent adult aerosol aged animal Argentina Chagas disease disease transmission drug effect family size female growth, development and aging human insect control longitudinal study male middle aged population group prevention and control procedures questionnaire Triatoma very elderly young adult Adolescent Adult Aerosols Aged Aged, 80 and over Animals Argentina Chagas Disease Disease Transmission, Infectious Family Characteristics Female Humans Insect Control Insecticides Longitudinal Studies Male Middle Aged Population Groups Pyrethrins Surveys and Questionnaires Triatoma Young Adult BACKGROUND: Rapid reinfestation of insecticide-treated dwellings hamper the sustained elimination of Triatoma infestans, the main vector of Chagas disease in the Gran Chaco region. We conducted a seven-year longitudinal study including community-wide spraying with pyrethroid insecticides combined with periodic vector surveillance to investigate the house reinfestation process in connection with baseline pyrethroid resistance, housing quality and household mobility in a rural section of Pampa del Indio mainly inhabited by deprived indigenous people (Qom). METHODOLOGY/PRINCIPAL FINDINGS: Despite evidence of moderate pyrethroid resistance in local T. infestans populations, house infestation dropped from 31.9% at baseline to 0.7% at 10 months post-spraying (MPS), with no triatomine found at 59 and 78 MPS. Household-based surveillance corroborated the rare occurrence of T. infestans and the house invasion of other four triatomine species. The annual rates of loss of initially occupied houses and of household mobility were high (4.6-8.0%). Housing improvements did not translate into a significant reduction of mud-walled houses and refuges for triatomines because most households kept the former dwelling or built new ones with mud walls. CONCLUSIONS/SIGNIFICANCE: Our results refute the assumption that vector control actions performed in marginalized communities of the Gran Chaco are doomed to fail. The larger-than-expected impacts of the intervention program were likely associated with the combined effects of high-coverage, professional insecticide spraying followed by systematic vector surveillance-and-response, broad geographic coverage creating a buffer zone, frequent housing replacement and residential mobility. The dynamical interactions among housing quality, mobility and insecticide-based control largely affect the chances of vector elimination. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19352735_v12_n10_pe0006804_Gaspe |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
insecticide pyrethroid administration and dosage adolescent adult aerosol aged animal Argentina Chagas disease disease transmission drug effect family size female growth, development and aging human insect control longitudinal study male middle aged population group prevention and control procedures questionnaire Triatoma very elderly young adult Adolescent Adult Aerosols Aged Aged, 80 and over Animals Argentina Chagas Disease Disease Transmission, Infectious Family Characteristics Female Humans Insect Control Insecticides Longitudinal Studies Male Middle Aged Population Groups Pyrethrins Surveys and Questionnaires Triatoma Young Adult |
| spellingShingle |
insecticide pyrethroid administration and dosage adolescent adult aerosol aged animal Argentina Chagas disease disease transmission drug effect family size female growth, development and aging human insect control longitudinal study male middle aged population group prevention and control procedures questionnaire Triatoma very elderly young adult Adolescent Adult Aerosols Aged Aged, 80 and over Animals Argentina Chagas Disease Disease Transmission, Infectious Family Characteristics Female Humans Insect Control Insecticides Longitudinal Studies Male Middle Aged Population Groups Pyrethrins Surveys and Questionnaires Triatoma Young Adult Gaspe, M.S. Provecho, Y.M. Fernández, M.P. Vassena, C.V. Santo Orihuela, P.L. Gürtler, R.E. Beating the odds: Sustained Chagas disease vector control in remote indigenous communities of the Argentine Chaco over a seven-year period |
| topic_facet |
insecticide pyrethroid administration and dosage adolescent adult aerosol aged animal Argentina Chagas disease disease transmission drug effect family size female growth, development and aging human insect control longitudinal study male middle aged population group prevention and control procedures questionnaire Triatoma very elderly young adult Adolescent Adult Aerosols Aged Aged, 80 and over Animals Argentina Chagas Disease Disease Transmission, Infectious Family Characteristics Female Humans Insect Control Insecticides Longitudinal Studies Male Middle Aged Population Groups Pyrethrins Surveys and Questionnaires Triatoma Young Adult |
| description |
BACKGROUND: Rapid reinfestation of insecticide-treated dwellings hamper the sustained elimination of Triatoma infestans, the main vector of Chagas disease in the Gran Chaco region. We conducted a seven-year longitudinal study including community-wide spraying with pyrethroid insecticides combined with periodic vector surveillance to investigate the house reinfestation process in connection with baseline pyrethroid resistance, housing quality and household mobility in a rural section of Pampa del Indio mainly inhabited by deprived indigenous people (Qom). METHODOLOGY/PRINCIPAL FINDINGS: Despite evidence of moderate pyrethroid resistance in local T. infestans populations, house infestation dropped from 31.9% at baseline to 0.7% at 10 months post-spraying (MPS), with no triatomine found at 59 and 78 MPS. Household-based surveillance corroborated the rare occurrence of T. infestans and the house invasion of other four triatomine species. The annual rates of loss of initially occupied houses and of household mobility were high (4.6-8.0%). Housing improvements did not translate into a significant reduction of mud-walled houses and refuges for triatomines because most households kept the former dwelling or built new ones with mud walls. CONCLUSIONS/SIGNIFICANCE: Our results refute the assumption that vector control actions performed in marginalized communities of the Gran Chaco are doomed to fail. The larger-than-expected impacts of the intervention program were likely associated with the combined effects of high-coverage, professional insecticide spraying followed by systematic vector surveillance-and-response, broad geographic coverage creating a buffer zone, frequent housing replacement and residential mobility. The dynamical interactions among housing quality, mobility and insecticide-based control largely affect the chances of vector elimination. |
| format |
JOUR |
| author |
Gaspe, M.S. Provecho, Y.M. Fernández, M.P. Vassena, C.V. Santo Orihuela, P.L. Gürtler, R.E. |
| author_facet |
Gaspe, M.S. Provecho, Y.M. Fernández, M.P. Vassena, C.V. Santo Orihuela, P.L. Gürtler, R.E. |
| author_sort |
Gaspe, M.S. |
| title |
Beating the odds: Sustained Chagas disease vector control in remote indigenous communities of the Argentine Chaco over a seven-year period |
| title_short |
Beating the odds: Sustained Chagas disease vector control in remote indigenous communities of the Argentine Chaco over a seven-year period |
| title_full |
Beating the odds: Sustained Chagas disease vector control in remote indigenous communities of the Argentine Chaco over a seven-year period |
| title_fullStr |
Beating the odds: Sustained Chagas disease vector control in remote indigenous communities of the Argentine Chaco over a seven-year period |
| title_full_unstemmed |
Beating the odds: Sustained Chagas disease vector control in remote indigenous communities of the Argentine Chaco over a seven-year period |
| title_sort |
beating the odds: sustained chagas disease vector control in remote indigenous communities of the argentine chaco over a seven-year period |
| url |
http://hdl.handle.net/20.500.12110/paper_19352735_v12_n10_pe0006804_Gaspe |
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