New insight into the interface chemistry and stability of glutathione self-assembled monolayers on Au(111)

In this paper we have studied glutathione (GSH) self-assembled monolayers (SAMs) on Au(111) prepared by incubation from solutions in phosphate buffer (pH = 7). These SAMs degrade with increasing immersion time to yield adsorbed S and polysulfide species on the gold surface, as revealed by cyclic vol...

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Detalles Bibliográficos
Autores principales: Lobo Maza, F., Méndez De Leo, L., Rubert, A.A., Carro, P., Salvarezza, R.C., Vericat, C.
Formato: JOUR
Materias:
Absorption spectroscopy
Cyclic voltammetry
Gold
Medical applications
Monolayers
Peptides
Photodegradation
X ray photoelectron spectroscopy
6-mercaptopurine (6MP)
Biomedical applications
Drug delivery applications
Interface chemistry
Phosphate buffers
Polarization modulation infrared reflection absorption spectroscopy
Triggered release
Vibrational bands
Self assembled monolayers
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19327447_v120_n27_p14597_LoboMaza
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_19327447_v120_n27_p14597_LoboMaza
record_format dspace
spelling todo:paper_19327447_v120_n27_p14597_LoboMaza2023-10-03T16:36:03Z New insight into the interface chemistry and stability of glutathione self-assembled monolayers on Au(111) Lobo Maza, F. Méndez De Leo, L. Rubert, A.A. Carro, P. Salvarezza, R.C. Vericat, C. Absorption spectroscopy Cyclic voltammetry Gold Medical applications Monolayers Peptides Photodegradation X ray photoelectron spectroscopy 6-mercaptopurine (6MP) Biomedical applications Drug delivery applications Interface chemistry Phosphate buffers Polarization modulation infrared reflection absorption spectroscopy Triggered release Vibrational bands Self assembled monolayers In this paper we have studied glutathione (GSH) self-assembled monolayers (SAMs) on Au(111) prepared by incubation from solutions in phosphate buffer (pH = 7). These SAMs degrade with increasing immersion time to yield adsorbed S and polysulfide species on the gold surface, as revealed by cyclic voltammetry and X-ray photoelectron spectroscopy. Results from polarization modulation infrared reflection-absorption spectroscopy (PM-IRRAS) show that even if GSH decomposes on the surface the vibrational bands characteristic of the molecule are still present. This has direct relevance for the study of gold nanoparticles (AuNPs) protected by hydrophilic thiols and also for biomedical applications of GSH-capped AuNPs. Thiol exchange experiments of the drug 6-mercaptopurine (6MP) SAMs on Au(111) in contact with GSH solutions were also performed to better understand the possible role of the latter in the triggered release of 6MP from the surface of AuNPs for drug delivery applications. Our results show that 6MP is completely released only when a S adlayer, produced by desulfurization of GSH, is formed on the Au(111) surface. © 2016 American Chemical Society. Fil:Méndez De Leo, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19327447_v120_n27_p14597_LoboMaza
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Absorption spectroscopy
Cyclic voltammetry
Gold
Medical applications
Monolayers
Peptides
Photodegradation
X ray photoelectron spectroscopy
6-mercaptopurine (6MP)
Biomedical applications
Drug delivery applications
Interface chemistry
Phosphate buffers
Polarization modulation infrared reflection absorption spectroscopy
Triggered release
Vibrational bands
Self assembled monolayers
spellingShingle Absorption spectroscopy
Cyclic voltammetry
Gold
Medical applications
Monolayers
Peptides
Photodegradation
X ray photoelectron spectroscopy
6-mercaptopurine (6MP)
Biomedical applications
Drug delivery applications
Interface chemistry
Phosphate buffers
Polarization modulation infrared reflection absorption spectroscopy
Triggered release
Vibrational bands
Self assembled monolayers
Lobo Maza, F.
Méndez De Leo, L.
Rubert, A.A.
Carro, P.
Salvarezza, R.C.
Vericat, C.
New insight into the interface chemistry and stability of glutathione self-assembled monolayers on Au(111)
topic_facet Absorption spectroscopy
Cyclic voltammetry
Gold
Medical applications
Monolayers
Peptides
Photodegradation
X ray photoelectron spectroscopy
6-mercaptopurine (6MP)
Biomedical applications
Drug delivery applications
Interface chemistry
Phosphate buffers
Polarization modulation infrared reflection absorption spectroscopy
Triggered release
Vibrational bands
Self assembled monolayers
description In this paper we have studied glutathione (GSH) self-assembled monolayers (SAMs) on Au(111) prepared by incubation from solutions in phosphate buffer (pH = 7). These SAMs degrade with increasing immersion time to yield adsorbed S and polysulfide species on the gold surface, as revealed by cyclic voltammetry and X-ray photoelectron spectroscopy. Results from polarization modulation infrared reflection-absorption spectroscopy (PM-IRRAS) show that even if GSH decomposes on the surface the vibrational bands characteristic of the molecule are still present. This has direct relevance for the study of gold nanoparticles (AuNPs) protected by hydrophilic thiols and also for biomedical applications of GSH-capped AuNPs. Thiol exchange experiments of the drug 6-mercaptopurine (6MP) SAMs on Au(111) in contact with GSH solutions were also performed to better understand the possible role of the latter in the triggered release of 6MP from the surface of AuNPs for drug delivery applications. Our results show that 6MP is completely released only when a S adlayer, produced by desulfurization of GSH, is formed on the Au(111) surface. © 2016 American Chemical Society.
format JOUR
author Lobo Maza, F.
Méndez De Leo, L.
Rubert, A.A.
Carro, P.
Salvarezza, R.C.
Vericat, C.
author_facet Lobo Maza, F.
Méndez De Leo, L.
Rubert, A.A.
Carro, P.
Salvarezza, R.C.
Vericat, C.
author_sort Lobo Maza, F.
title New insight into the interface chemistry and stability of glutathione self-assembled monolayers on Au(111)
title_short New insight into the interface chemistry and stability of glutathione self-assembled monolayers on Au(111)
title_full New insight into the interface chemistry and stability of glutathione self-assembled monolayers on Au(111)
title_fullStr New insight into the interface chemistry and stability of glutathione self-assembled monolayers on Au(111)
title_full_unstemmed New insight into the interface chemistry and stability of glutathione self-assembled monolayers on Au(111)
title_sort new insight into the interface chemistry and stability of glutathione self-assembled monolayers on au(111)
url http://hdl.handle.net/20.500.12110/paper_19327447_v120_n27_p14597_LoboMaza
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AT rubertaa newinsightintotheinterfacechemistryandstabilityofglutathioneselfassembledmonolayersonau111
AT carrop newinsightintotheinterfacechemistryandstabilityofglutathioneselfassembledmonolayersonau111
AT salvarezzarc newinsightintotheinterfacechemistryandstabilityofglutathioneselfassembledmonolayersonau111
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