Retroactive signaling in short signaling pathways
In biochemical signaling pathways without explicit feedback connections, the core signal transduction is usually described as a one-way communication, going from upstream to downstream in a feedforward chain or network of covalent modification cycles. In this paper we explore the possibility of a ne...
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todo:paper_19326203_v7_n7_p_Sepulchre2023-10-03T16:35:24Z Retroactive signaling in short signaling pathways Sepulchre, J.-A. Merajver, S.D. Ventura, A.C. phosphatase article enzyme inactivation intracellular signaling negative feedback positive feedback protein analysis protein modification retroactive signaling signal transduction Enzyme Activation Models, Biological Phosphoprotein Phosphatases Signal Transduction In biochemical signaling pathways without explicit feedback connections, the core signal transduction is usually described as a one-way communication, going from upstream to downstream in a feedforward chain or network of covalent modification cycles. In this paper we explore the possibility of a new type of signaling called retroactive signaling, offered by the recently demonstrated property of retroactivity in signaling cascades. The possibility of retroactive signaling is analysed in the simplest case of the stationary states of a bicyclic cascade of signaling cycles. In this case, we work out the conditions for which variables of the upstream cycle are affected by a change of the total amount of protein in the downstream cycle, or by a variation of the phosphatase deactivating the same protein. Particularly, we predict the characteristic ranges of the downstream protein, or of the downstream phosphatase, for which a retroactive effect can be observed on the upstream cycle variables. Next, we extend the possibility of retroactive signaling in short but nonlinear signaling pathways involving a few covalent modification cycles. © 2012 Sepulchre et al. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19326203_v7_n7_p_Sepulchre |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
phosphatase article enzyme inactivation intracellular signaling negative feedback positive feedback protein analysis protein modification retroactive signaling signal transduction Enzyme Activation Models, Biological Phosphoprotein Phosphatases Signal Transduction |
| spellingShingle |
phosphatase article enzyme inactivation intracellular signaling negative feedback positive feedback protein analysis protein modification retroactive signaling signal transduction Enzyme Activation Models, Biological Phosphoprotein Phosphatases Signal Transduction Sepulchre, J.-A. Merajver, S.D. Ventura, A.C. Retroactive signaling in short signaling pathways |
| topic_facet |
phosphatase article enzyme inactivation intracellular signaling negative feedback positive feedback protein analysis protein modification retroactive signaling signal transduction Enzyme Activation Models, Biological Phosphoprotein Phosphatases Signal Transduction |
| description |
In biochemical signaling pathways without explicit feedback connections, the core signal transduction is usually described as a one-way communication, going from upstream to downstream in a feedforward chain or network of covalent modification cycles. In this paper we explore the possibility of a new type of signaling called retroactive signaling, offered by the recently demonstrated property of retroactivity in signaling cascades. The possibility of retroactive signaling is analysed in the simplest case of the stationary states of a bicyclic cascade of signaling cycles. In this case, we work out the conditions for which variables of the upstream cycle are affected by a change of the total amount of protein in the downstream cycle, or by a variation of the phosphatase deactivating the same protein. Particularly, we predict the characteristic ranges of the downstream protein, or of the downstream phosphatase, for which a retroactive effect can be observed on the upstream cycle variables. Next, we extend the possibility of retroactive signaling in short but nonlinear signaling pathways involving a few covalent modification cycles. © 2012 Sepulchre et al. |
| format |
JOUR |
| author |
Sepulchre, J.-A. Merajver, S.D. Ventura, A.C. |
| author_facet |
Sepulchre, J.-A. Merajver, S.D. Ventura, A.C. |
| author_sort |
Sepulchre, J.-A. |
| title |
Retroactive signaling in short signaling pathways |
| title_short |
Retroactive signaling in short signaling pathways |
| title_full |
Retroactive signaling in short signaling pathways |
| title_fullStr |
Retroactive signaling in short signaling pathways |
| title_full_unstemmed |
Retroactive signaling in short signaling pathways |
| title_sort |
retroactive signaling in short signaling pathways |
| url |
http://hdl.handle.net/20.500.12110/paper_19326203_v7_n7_p_Sepulchre |
| work_keys_str_mv |
AT sepulchreja retroactivesignalinginshortsignalingpathways AT merajversd retroactivesignalinginshortsignalingpathways AT venturaac retroactivesignalinginshortsignalingpathways |
| _version_ |
1782026860551471104 |