Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness

Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whethe...

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Autores principales: Mitra, A., Snyder, A.Z., Tagliazucchi, E., Laufs, H., Elison, J., Emerson, R.W., Shen, M.D., Wolff, J.J., Botteron, K.N., Dager, S., Estes, A.M., Evans, A.C., Gerig, G., Hazlett, H.C., Paterson, S.J., Schultz, R.T., Styner, M.A., Zwaigenbaum, L., Chappell, C., Estes, A., Shaw, D., Botteron, K., McKinstry, R., Constantino, J., Pruett, J., Schultz, R., Paterson, S., Collins, D.L., Pike, G.B., Fonov, V., Kostopoulos, P., Das, S., Styner, M., Gu, H., Schlaggar, B.L., Piven, J., Pruett, J.R., Jr., Raichle, M.
Formato: JOUR
Materias:
BOLD signal
child
controlled study
default mode network
drawing
female
functional connectivity
functional magnetic resonance imaging
human
human experiment
infant
male
nonREM sleep
preschool child
rest
thalamus
wakefulness
adult
anatomy and histology
brain
connectome
electroencephalography
growth, development and aging
nuclear magnetic resonance imaging
physiology
principal component analysis
sleep
statistics and numerical data
Adult
Brain
Child, Preschool
Connectome
Electroencephalography
Humans
Infant
Magnetic Resonance Imaging
Principal Component Analysis
Sleep
Wakefulness
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v12_n11_p_Mitra
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_19326203_v12_n11_p_Mitra
record_format dspace
spelling todo:paper_19326203_v12_n11_p_Mitra2023-10-03T16:34:46Z Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness Mitra, A. Snyder, A.Z. Tagliazucchi, E. Laufs, H. Elison, J. Emerson, R.W. Shen, M.D. Wolff, J.J. Botteron, K.N. Dager, S. Estes, A.M. Evans, A.C. Gerig, G. Hazlett, H.C. Paterson, S.J. Schultz, R.T. Styner, M.A. Zwaigenbaum, L. Chappell, C. Estes, A. Shaw, D. Botteron, K. McKinstry, R. Constantino, J. Pruett, J. Schultz, R. Paterson, S. Collins, D.L. Pike, G.B. Fonov, V. Kostopoulos, P. Das, S. Styner, M. Gu, H. Schlaggar, B.L. Piven, J. Pruett, J.R., Jr. Raichle, M. BOLD signal child controlled study default mode network drawing female functional connectivity functional magnetic resonance imaging human human experiment infant male nonREM sleep preschool child rest thalamus wakefulness adult anatomy and histology brain connectome electroencephalography growth, development and aging nuclear magnetic resonance imaging physiology principal component analysis sleep statistics and numerical data wakefulness Adult Brain Child, Preschool Connectome Electroencephalography Humans Infant Magnetic Resonance Imaging Principal Component Analysis Sleep Wakefulness Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs. sleep are well documented. To investigate this question, we compared functional connectivity and BOLD signal propagation patterns in 6, 12, and 24 month old sleeping infants with patterns in adult wakefulness and non-REM sleep. We find that important functional connectivity features seen during infant sleep closely resemble those seen during adult sleep, including reduced default mode network functional connectivity. However, we also find differences between infant and adult sleep, especially in thalamic BOLD signal propagation patterns. These findings highlight the importance of considering sleep state when drawing developmental inferences in infant rs-fMRI. © 2017 Mitra et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19326203_v12_n11_p_Mitra
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic BOLD signal
child
controlled study
default mode network
drawing
female
functional connectivity
functional magnetic resonance imaging
human
human experiment
infant
male
nonREM sleep
preschool child
rest
thalamus
wakefulness
adult
anatomy and histology
brain
connectome
electroencephalography
growth, development and aging
nuclear magnetic resonance imaging
physiology
principal component analysis
sleep
statistics and numerical data
wakefulness
Adult
Brain
Child, Preschool
Connectome
Electroencephalography
Humans
Infant
Magnetic Resonance Imaging
Principal Component Analysis
Sleep
Wakefulness
spellingShingle BOLD signal
child
controlled study
default mode network
drawing
female
functional connectivity
functional magnetic resonance imaging
human
human experiment
infant
male
nonREM sleep
preschool child
rest
thalamus
wakefulness
adult
anatomy and histology
brain
connectome
electroencephalography
growth, development and aging
nuclear magnetic resonance imaging
physiology
principal component analysis
sleep
statistics and numerical data
wakefulness
Adult
Brain
Child, Preschool
Connectome
Electroencephalography
Humans
Infant
Magnetic Resonance Imaging
Principal Component Analysis
Sleep
Wakefulness
Mitra, A.
Snyder, A.Z.
Tagliazucchi, E.
Laufs, H.
Elison, J.
Emerson, R.W.
Shen, M.D.
Wolff, J.J.
Botteron, K.N.
Dager, S.
Estes, A.M.
Evans, A.C.
Gerig, G.
Hazlett, H.C.
Paterson, S.J.
Schultz, R.T.
Styner, M.A.
Zwaigenbaum, L.
Chappell, C.
Estes, A.
Shaw, D.
Botteron, K.
McKinstry, R.
Constantino, J.
Pruett, J.
Schultz, R.
Paterson, S.
Collins, D.L.
Pike, G.B.
Fonov, V.
Kostopoulos, P.
Das, S.
Styner, M.
Gu, H.
Schlaggar, B.L.
Piven, J.
Pruett, J.R., Jr.
Raichle, M.
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness
topic_facet BOLD signal
child
controlled study
default mode network
drawing
female
functional connectivity
functional magnetic resonance imaging
human
human experiment
infant
male
nonREM sleep
preschool child
rest
thalamus
wakefulness
adult
anatomy and histology
brain
connectome
electroencephalography
growth, development and aging
nuclear magnetic resonance imaging
physiology
principal component analysis
sleep
statistics and numerical data
wakefulness
Adult
Brain
Child, Preschool
Connectome
Electroencephalography
Humans
Infant
Magnetic Resonance Imaging
Principal Component Analysis
Sleep
Wakefulness
description Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs. sleep are well documented. To investigate this question, we compared functional connectivity and BOLD signal propagation patterns in 6, 12, and 24 month old sleeping infants with patterns in adult wakefulness and non-REM sleep. We find that important functional connectivity features seen during infant sleep closely resemble those seen during adult sleep, including reduced default mode network functional connectivity. However, we also find differences between infant and adult sleep, especially in thalamic BOLD signal propagation patterns. These findings highlight the importance of considering sleep state when drawing developmental inferences in infant rs-fMRI. © 2017 Mitra et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
format JOUR
author Mitra, A.
Snyder, A.Z.
Tagliazucchi, E.
Laufs, H.
Elison, J.
Emerson, R.W.
Shen, M.D.
Wolff, J.J.
Botteron, K.N.
Dager, S.
Estes, A.M.
Evans, A.C.
Gerig, G.
Hazlett, H.C.
Paterson, S.J.
Schultz, R.T.
Styner, M.A.
Zwaigenbaum, L.
Chappell, C.
Estes, A.
Shaw, D.
Botteron, K.
McKinstry, R.
Constantino, J.
Pruett, J.
Schultz, R.
Paterson, S.
Collins, D.L.
Pike, G.B.
Fonov, V.
Kostopoulos, P.
Das, S.
Styner, M.
Gu, H.
Schlaggar, B.L.
Piven, J.
Pruett, J.R., Jr.
Raichle, M.
author_facet Mitra, A.
Snyder, A.Z.
Tagliazucchi, E.
Laufs, H.
Elison, J.
Emerson, R.W.
Shen, M.D.
Wolff, J.J.
Botteron, K.N.
Dager, S.
Estes, A.M.
Evans, A.C.
Gerig, G.
Hazlett, H.C.
Paterson, S.J.
Schultz, R.T.
Styner, M.A.
Zwaigenbaum, L.
Chappell, C.
Estes, A.
Shaw, D.
Botteron, K.
McKinstry, R.
Constantino, J.
Pruett, J.
Schultz, R.
Paterson, S.
Collins, D.L.
Pike, G.B.
Fonov, V.
Kostopoulos, P.
Das, S.
Styner, M.
Gu, H.
Schlaggar, B.L.
Piven, J.
Pruett, J.R., Jr.
Raichle, M.
author_sort Mitra, A.
title Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness
title_short Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness
title_full Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness
title_fullStr Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness
title_full_unstemmed Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness
title_sort resting-state fmri in sleeping infants more closely resembles adult sleep than adult wakefulness
url http://hdl.handle.net/20.500.12110/paper_19326203_v12_n11_p_Mitra
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