Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process

Consolidated memories return to a labile state after the presentation of cues (reminders) associated with acquisition, followed by a period of stabilization (reconsolidation). However not all cues are equally effective in initiating the process, unpredictable cues triggered it, predictable cues do n...

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Autores principales: Forcato, C., Bavassi, L., De Pino, G., Fernández, R.S., Villarreal, M.F., Pedreira, M.E.
Formato: JOUR
Materias:
comparative effectiveness
controlled study
functional magnetic resonance imaging
hippocampus
human
information retrieval
memory
adolescent
adult
association
female
learning
male
non-therapeutic research
nuclear magnetic resonance imaging
physiology
recall
reminder system
young adult
Adolescent
Adult
Association Learning
Cues
Female
Hippocampus
Humans
Magnetic Resonance Imaging
Male
Memory
Mental Recall
Nontherapeutic Human Experimentation
Reminder Systems
Young Adult
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v11_n3_p_Forcato
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_19326203_v11_n3_p_Forcato
record_format dspace
spelling todo:paper_19326203_v11_n3_p_Forcato2023-10-03T16:34:41Z Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process Forcato, C. Bavassi, L. De Pino, G. Fernández, R.S. Villarreal, M.F. Pedreira, M.E. comparative effectiveness controlled study functional magnetic resonance imaging hippocampus human information retrieval memory adolescent adult association female hippocampus learning male non-therapeutic research nuclear magnetic resonance imaging physiology recall reminder system young adult Adolescent Adult Association Learning Cues Female Hippocampus Humans Magnetic Resonance Imaging Male Memory Mental Recall Nontherapeutic Human Experimentation Reminder Systems Young Adult Consolidated memories return to a labile state after the presentation of cues (reminders) associated with acquisition, followed by a period of stabilization (reconsolidation). However not all cues are equally effective in initiating the process, unpredictable cues triggered it, predictable cues do not. We hypothesize that the different effects observed by the different reminder types on memory labilization-reconsolidation depend on a differential neural involvement during reminder presentation. To test it, we developed a declarative task and compared the efficacy of three reminder types in triggering the process in humans (Experiment 1). Finally, we compared the brain activation patterns between the different conditions using functional magnetic resonance imaging (fMRI) (Experiment 2). We confirmed that the unpredictable reminder is the most effective in initiating the labilization-reconsolidation process. Furthermore, only under this condition there was differential left hippocampal activation during its presentation.We suggest that the left hippocampus is detecting the incongruence between actual and past events and allows the memory to be updated. © 2016 Forcato et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fil:Forcato, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bavassi, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pedreira, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19326203_v11_n3_p_Forcato
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic comparative effectiveness
controlled study
functional magnetic resonance imaging
hippocampus
human
information retrieval
memory
adolescent
adult
association
female
hippocampus
learning
male
non-therapeutic research
nuclear magnetic resonance imaging
physiology
recall
reminder system
young adult
Adolescent
Adult
Association Learning
Cues
Female
Hippocampus
Humans
Magnetic Resonance Imaging
Male
Memory
Mental Recall
Nontherapeutic Human Experimentation
Reminder Systems
Young Adult
spellingShingle comparative effectiveness
controlled study
functional magnetic resonance imaging
hippocampus
human
information retrieval
memory
adolescent
adult
association
female
hippocampus
learning
male
non-therapeutic research
nuclear magnetic resonance imaging
physiology
recall
reminder system
young adult
Adolescent
Adult
Association Learning
Cues
Female
Hippocampus
Humans
Magnetic Resonance Imaging
Male
Memory
Mental Recall
Nontherapeutic Human Experimentation
Reminder Systems
Young Adult
Forcato, C.
Bavassi, L.
De Pino, G.
Fernández, R.S.
Villarreal, M.F.
Pedreira, M.E.
Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process
topic_facet comparative effectiveness
controlled study
functional magnetic resonance imaging
hippocampus
human
information retrieval
memory
adolescent
adult
association
female
hippocampus
learning
male
non-therapeutic research
nuclear magnetic resonance imaging
physiology
recall
reminder system
young adult
Adolescent
Adult
Association Learning
Cues
Female
Hippocampus
Humans
Magnetic Resonance Imaging
Male
Memory
Mental Recall
Nontherapeutic Human Experimentation
Reminder Systems
Young Adult
description Consolidated memories return to a labile state after the presentation of cues (reminders) associated with acquisition, followed by a period of stabilization (reconsolidation). However not all cues are equally effective in initiating the process, unpredictable cues triggered it, predictable cues do not. We hypothesize that the different effects observed by the different reminder types on memory labilization-reconsolidation depend on a differential neural involvement during reminder presentation. To test it, we developed a declarative task and compared the efficacy of three reminder types in triggering the process in humans (Experiment 1). Finally, we compared the brain activation patterns between the different conditions using functional magnetic resonance imaging (fMRI) (Experiment 2). We confirmed that the unpredictable reminder is the most effective in initiating the labilization-reconsolidation process. Furthermore, only under this condition there was differential left hippocampal activation during its presentation.We suggest that the left hippocampus is detecting the incongruence between actual and past events and allows the memory to be updated. © 2016 Forcato et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
format JOUR
author Forcato, C.
Bavassi, L.
De Pino, G.
Fernández, R.S.
Villarreal, M.F.
Pedreira, M.E.
author_facet Forcato, C.
Bavassi, L.
De Pino, G.
Fernández, R.S.
Villarreal, M.F.
Pedreira, M.E.
author_sort Forcato, C.
title Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process
title_short Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process
title_full Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process
title_fullStr Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process
title_full_unstemmed Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process
title_sort differential left hippocampal activation during retrieval with different types of reminders: an fmri study of the reconsolidation process
url http://hdl.handle.net/20.500.12110/paper_19326203_v11_n3_p_Forcato
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