In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B

Lung cancer is the most deadly type of cancer in humans, with non-small-cell lung cancer (NSCLC) being the most frequent and aggressive type of lung cancer showing high resistance to radiation and chemotherapy. Despite the outstanding progress made in anti-tumor therapy, discovering effective anti-t...

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Detalles Bibliográficos
Autores principales: Silva, I.T., Carvalho, A., Lang, K.L., Dudek, S.E., Masemann, D., Durán, F.J., Caro, M.S.B., Rapp, U.R., Wixler, V., Schenkel, E.P., Simões, C.M.O., Ludwig, S.
Formato: JOUR
Materias:
2 deoxy 2 amine cucurbitacin E
caspase 3
cucurbitacin
epidermal growth factor receptor
mitogen activated protein kinase
protein kinase B
Raf protein
STAT3 protein
staurosporine
surfactant protein C
unclassified drug
antineoplastic agent
apoptosis regulatory protein
cucurbitacin B
phosphatidylinositol 3 kinase
triterpene
animal cell
animal experiment
animal model
antineoplastic activity
apoptosis
Article
cancer inhibition
cell cycle arrest
cell proliferation
controlled study
drug structure
G2 phase cell cycle checkpoint
human
human cell
in vitro study
in vivo study
lung alveolus epithelium
male
non small cell lung cancer
nonhuman
protein expression
protein phosphorylation
signal transduction
animal
Carcinoma, Non-Small-Cell Lung
cell cycle checkpoint
cytoskeleton
disease model
drug effects
drug screening
genetics
Lung Neoplasms
metabolism
mouse
pathology
phosphorylation
synthesis
transgenic mouse
tumor cell line
Animals
Antineoplastic Agents
Apoptosis
Apoptosis Regulatory Proteins
Caspase 3
Cell Cycle Checkpoints
Cell Line, Tumor
Cell Proliferation
Cytoskeleton
Disease Models, Animal
Humans
Male
Mice
Mice, Transgenic
Phosphatidylinositol 3-Kinases
Phosphorylation
Proto-Oncogene Proteins c-akt
raf Kinases
Receptor, Epidermal Growth Factor
Signal Transduction
STAT3 Transcription Factor
Triterpenes
Tumor Stem Cell Assay
Xenograft Model Antitumor Assays
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v10_n2_p_Silva
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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