Carbohydrate PEGylation, an approach to improve pharmacological potency

Conjugation with polyethylene glycol (PEG), known as PEGylation, has been widely used to improve the bioavailability of proteins and low molecular weight drugs. The covalent conjugation of PEG to the carbohydrate moiety of a protein has been mainly used to enhance the pharmacokinetic properties of t...

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Autores principales: Giorgi, M.E., Agusti, R., De Lederkremer, R.M.
Formato: JOUR
Materias:
Bioavailability
Carbohydrates
Conjugates
Glycopegylation
Multivalent glycosystems
Multivalent PEGylation
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_18605397_v10_n_p1433_Giorgi
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_18605397_v10_n_p1433_Giorgi2023-10-03T16:33:17Z Carbohydrate PEGylation, an approach to improve pharmacological potency Giorgi, M.E. Agusti, R. De Lederkremer, R.M. Bioavailability Carbohydrates Conjugates Glycopegylation Multivalent glycosystems Multivalent PEGylation Conjugation with polyethylene glycol (PEG), known as PEGylation, has been widely used to improve the bioavailability of proteins and low molecular weight drugs. The covalent conjugation of PEG to the carbohydrate moiety of a protein has been mainly used to enhance the pharmacokinetic properties of the attached protein while yielding a more defined product. Thus, glycoPEGylation was successfully applied to the introduction of a PEGylated sialic acid to a preexisting or enzymatically linked glycan in a protein. Carbohydrates are now recognized as playing an important role in host-pathogen interactions in protozoal, bacterial and viral infections and are consequently candidates for chemotherapy. The short in vivo half-life of low molecular weight glycans hampered their use but methods for the covalent attachment of PEG have been less exploited. In this review, information on the preparation and application of PEG-carbohydrates, in particular multiarm PEGylation, is presented. © 2014 Giorgi et al. Fil:Giorgi, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Agusti, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:De Lederkremer, R.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_18605397_v10_n_p1433_Giorgi
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Bioavailability
Carbohydrates
Conjugates
Glycopegylation
Multivalent glycosystems
Multivalent PEGylation
spellingShingle Bioavailability
Carbohydrates
Conjugates
Glycopegylation
Multivalent glycosystems
Multivalent PEGylation
Giorgi, M.E.
Agusti, R.
De Lederkremer, R.M.
Carbohydrate PEGylation, an approach to improve pharmacological potency
topic_facet Bioavailability
Carbohydrates
Conjugates
Glycopegylation
Multivalent glycosystems
Multivalent PEGylation
description Conjugation with polyethylene glycol (PEG), known as PEGylation, has been widely used to improve the bioavailability of proteins and low molecular weight drugs. The covalent conjugation of PEG to the carbohydrate moiety of a protein has been mainly used to enhance the pharmacokinetic properties of the attached protein while yielding a more defined product. Thus, glycoPEGylation was successfully applied to the introduction of a PEGylated sialic acid to a preexisting or enzymatically linked glycan in a protein. Carbohydrates are now recognized as playing an important role in host-pathogen interactions in protozoal, bacterial and viral infections and are consequently candidates for chemotherapy. The short in vivo half-life of low molecular weight glycans hampered their use but methods for the covalent attachment of PEG have been less exploited. In this review, information on the preparation and application of PEG-carbohydrates, in particular multiarm PEGylation, is presented. © 2014 Giorgi et al.
format JOUR
author Giorgi, M.E.
Agusti, R.
De Lederkremer, R.M.
author_facet Giorgi, M.E.
Agusti, R.
De Lederkremer, R.M.
author_sort Giorgi, M.E.
title Carbohydrate PEGylation, an approach to improve pharmacological potency
title_short Carbohydrate PEGylation, an approach to improve pharmacological potency
title_full Carbohydrate PEGylation, an approach to improve pharmacological potency
title_fullStr Carbohydrate PEGylation, an approach to improve pharmacological potency
title_full_unstemmed Carbohydrate PEGylation, an approach to improve pharmacological potency
title_sort carbohydrate pegylation, an approach to improve pharmacological potency
url http://hdl.handle.net/20.500.12110/paper_18605397_v10_n_p1433_Giorgi
work_keys_str_mv AT giorgime carbohydratepegylationanapproachtoimprovepharmacologicalpotency
AT agustir carbohydratepegylationanapproachtoimprovepharmacologicalpotency
AT delederkremerrm carbohydratepegylationanapproachtoimprovepharmacologicalpotency
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