Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties

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Fused heterobicyclic systems have gained much importance in the field of medicinal chemistry because of their broad spectrum of physiological activities. Among the heterocyclic rings containing bridgehead nitrogen atom, imidazothiazoles derivatives are especially attractive because of their differen...

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Detalles Bibliográficos
Autores principales: Fascio, M.L., Errea, M.I., D'Accorso, N.B.
Formato: JOUR
Materias:
Biological activities
Imidazo[2,1-b]thiazoles
Imidazo[2,1-b][1,3,4]thiadiazoles
Imidazo[2,1-c][1,2,4]triazoles
Pyrrolo[2,1-b]thiazoles
antiinfective agent
antineoplastic agent
antivirus agent
heterocyclic compound
imidazole derivative
thiazole derivative
animal
cell proliferation
chemistry
drug effects
human
synthesis
Animals
Anti-Bacterial Agents
Antineoplastic Agents
Antiviral Agents
Cell Proliferation
Heterocyclic Compounds
Humans
Imidazoles
Thiazoles
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_17683254_v90_n_p666_Fascio
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_17683254_v90_n_p666_Fascio
record_format dspace
spelling todo:paper_17683254_v90_n_p666_Fascio2023-10-03T16:32:51Z Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties Fascio, M.L. Errea, M.I. D'Accorso, N.B. Biological activities Imidazo[2,1-b]thiazoles Imidazo[2,1-b][1,3,4]thiadiazoles Imidazo[2,1-c][1,2,4]triazoles Pyrrolo[2,1-b]thiazoles antiinfective agent antineoplastic agent antivirus agent heterocyclic compound imidazole derivative thiazole derivative animal cell proliferation chemistry drug effects human synthesis Animals Anti-Bacterial Agents Antineoplastic Agents Antiviral Agents Cell Proliferation Heterocyclic Compounds Humans Imidazoles Thiazoles Fused heterobicyclic systems have gained much importance in the field of medicinal chemistry because of their broad spectrum of physiological activities. Among the heterocyclic rings containing bridgehead nitrogen atom, imidazothiazoles derivatives are especially attractive because of their different biological activities. Since many imidazothiazoles derivatives are effective for treating several diseases, is interesting to analyze the behavior of some isosteric related heterocycles, such as pirrolothiazoles, imidazothiadiazoles and imidazotriazoles. In this context, this review summarizes the current knowledge about the syntheses and biological behavior of these families of heterocycles. Traditional synthetic methodologies as well as alternative synthetic procedures are described. Among these last methodologies, the use of multicomponent reaction, novel and efficient coupling reagents, and environmental friendly strategies, like microwave assistance and solvent-free condition in ionic liquids are also summarized. This review includes the biological assessments, docking research and studies of mechanism of action performed in order to obtain the compounds leading to the development of new drugs. Copyright © 2015 Elsevier Masson SAS. All rights reserved. Fil:Fascio, M.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Errea, M.I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:D'Accorso, N.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_17683254_v90_n_p666_Fascio
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Biological activities
Imidazo[2,1-b]thiazoles
Imidazo[2,1-b][1,3,4]thiadiazoles
Imidazo[2,1-c][1,2,4]triazoles
Pyrrolo[2,1-b]thiazoles
antiinfective agent
antineoplastic agent
antivirus agent
heterocyclic compound
imidazole derivative
thiazole derivative
animal
cell proliferation
chemistry
drug effects
human
synthesis
Animals
Anti-Bacterial Agents
Antineoplastic Agents
Antiviral Agents
Cell Proliferation
Heterocyclic Compounds
Humans
Imidazoles
Thiazoles
spellingShingle Biological activities
Imidazo[2,1-b]thiazoles
Imidazo[2,1-b][1,3,4]thiadiazoles
Imidazo[2,1-c][1,2,4]triazoles
Pyrrolo[2,1-b]thiazoles
antiinfective agent
antineoplastic agent
antivirus agent
heterocyclic compound
imidazole derivative
thiazole derivative
animal
cell proliferation
chemistry
drug effects
human
synthesis
Animals
Anti-Bacterial Agents
Antineoplastic Agents
Antiviral Agents
Cell Proliferation
Heterocyclic Compounds
Humans
Imidazoles
Thiazoles
Fascio, M.L.
Errea, M.I.
D'Accorso, N.B.
Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties
topic_facet Biological activities
Imidazo[2,1-b]thiazoles
Imidazo[2,1-b][1,3,4]thiadiazoles
Imidazo[2,1-c][1,2,4]triazoles
Pyrrolo[2,1-b]thiazoles
antiinfective agent
antineoplastic agent
antivirus agent
heterocyclic compound
imidazole derivative
thiazole derivative
animal
cell proliferation
chemistry
drug effects
human
synthesis
Animals
Anti-Bacterial Agents
Antineoplastic Agents
Antiviral Agents
Cell Proliferation
Heterocyclic Compounds
Humans
Imidazoles
Thiazoles
description Fused heterobicyclic systems have gained much importance in the field of medicinal chemistry because of their broad spectrum of physiological activities. Among the heterocyclic rings containing bridgehead nitrogen atom, imidazothiazoles derivatives are especially attractive because of their different biological activities. Since many imidazothiazoles derivatives are effective for treating several diseases, is interesting to analyze the behavior of some isosteric related heterocycles, such as pirrolothiazoles, imidazothiadiazoles and imidazotriazoles. In this context, this review summarizes the current knowledge about the syntheses and biological behavior of these families of heterocycles. Traditional synthetic methodologies as well as alternative synthetic procedures are described. Among these last methodologies, the use of multicomponent reaction, novel and efficient coupling reagents, and environmental friendly strategies, like microwave assistance and solvent-free condition in ionic liquids are also summarized. This review includes the biological assessments, docking research and studies of mechanism of action performed in order to obtain the compounds leading to the development of new drugs. Copyright © 2015 Elsevier Masson SAS. All rights reserved.
format JOUR
author Fascio, M.L.
Errea, M.I.
D'Accorso, N.B.
author_facet Fascio, M.L.
Errea, M.I.
D'Accorso, N.B.
author_sort Fascio, M.L.
title Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties
title_short Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties
title_full Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties
title_fullStr Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties
title_full_unstemmed Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties
title_sort imidazothiazole and related heterocyclic systems. synthesis, chemical and biological properties
url http://hdl.handle.net/20.500.12110/paper_17683254_v90_n_p666_Fascio
work_keys_str_mv AT fascioml imidazothiazoleandrelatedheterocyclicsystemssynthesischemicalandbiologicalproperties
AT erreami imidazothiazoleandrelatedheterocyclicsystemssynthesischemicalandbiologicalproperties
AT daccorsonb imidazothiazoleandrelatedheterocyclicsystemssynthesischemicalandbiologicalproperties
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