Single-cell profiling screen identifies microtubule-dependent reduction of variability in signaling

Populations of isogenic cells often respond coherently to signals, despite differences in protein abundance and cell state. Previously, we uncovered processes in the Saccharomyces cerevisiae pheromone response system (PRS) that reduced cell-to-cell variability in signal strength and cellular respons...

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Detalles Bibliográficos
Autores principales: Pesce, C.G., Zdraljevic, S., Peria, W.J., Bush, A., Repetto, M.V., Rockwell, D., Yu, R.C., Colman-Lerner, A., Brent, R.
Formato: JOUR
Materias:
cell-to-cell variability
genetic screen
MAP kinase
microtubules
noise
BIM1 protein, S cerevisiae
cell cycle protein
FUS3 protein, S cerevisiae
microtubule protein
mitogen activated protein kinase
pheromone
Saccharomyces cerevisiae protein
signal transducing adaptor protein
STE5 protein, S cerevisiae
genetics
MAPK signaling
metabolism
microtubule
Saccharomyces cerevisiae
signal transduction
single cell analysis
Adaptor Proteins, Signal Transducing
Cell Cycle Proteins
MAP Kinase Signaling System
Microtubule Proteins
Microtubules
Mitogen-Activated Protein Kinases
Pheromones
Saccharomyces cerevisiae Proteins
Signal Transduction
Single-Cell Analysis
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_17444292_v14_n4_p_Pesce
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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