Fabrication and characterization of porous PHBV scaffolds for tissue engineering
Porous scaffolds of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) were elaborated by three different techniques: salt leaching (SL), emulsion solvent evaporation (ESE) and temperature induced phase separation (TIPS). For SL partially fused sieved grains of sodium chloride (106-355 μm) were used as po...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_17426588_v332_n1_p_Ruiz |
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todo:paper_17426588_v332_n1_p_Ruiz2023-10-03T16:30:41Z Fabrication and characterization of porous PHBV scaffolds for tissue engineering Ruiz, I. Hermida, É.B. Baldessari, A. Alkalinity Biomedical engineering Emulsification Enzymatic hydrolysis Irradiation Phase separation Pore size Tissue engineering Emulsion solvent evaporation Fabrication and characterizations Gamma irradiation Interconnected structures Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Scaffolds for tissue engineering Temperature-induced phase separation Three different techniques Scaffolds (biology) Porous scaffolds of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) were elaborated by three different techniques: salt leaching (SL), emulsion solvent evaporation (ESE) and temperature induced phase separation (TIPS). For SL partially fused sieved grains of sodium chloride (106-355 μm) were used as porogen. Emulsions, prepared from a solution of PHBV in chloroform allow getting flexible films; the content of surfactant may be used to control the pore size. The pore size of the TIPS scaffolds decreased on increasing the cooling rate and the morphology of the interconnected structure could be controlled by changing the temperature gradient. Finally, chemical changes associated to the enhancement of hydrophilic behaviour of the scaffolds after alkaline and enzymatic hydrolysis as well as after sterilization by γ irradiation are presented. CONF info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_17426588_v332_n1_p_Ruiz |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Alkalinity Biomedical engineering Emulsification Enzymatic hydrolysis Irradiation Phase separation Pore size Tissue engineering Emulsion solvent evaporation Fabrication and characterizations Gamma irradiation Interconnected structures Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Scaffolds for tissue engineering Temperature-induced phase separation Three different techniques Scaffolds (biology) |
| spellingShingle |
Alkalinity Biomedical engineering Emulsification Enzymatic hydrolysis Irradiation Phase separation Pore size Tissue engineering Emulsion solvent evaporation Fabrication and characterizations Gamma irradiation Interconnected structures Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Scaffolds for tissue engineering Temperature-induced phase separation Three different techniques Scaffolds (biology) Ruiz, I. Hermida, É.B. Baldessari, A. Fabrication and characterization of porous PHBV scaffolds for tissue engineering |
| topic_facet |
Alkalinity Biomedical engineering Emulsification Enzymatic hydrolysis Irradiation Phase separation Pore size Tissue engineering Emulsion solvent evaporation Fabrication and characterizations Gamma irradiation Interconnected structures Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Scaffolds for tissue engineering Temperature-induced phase separation Three different techniques Scaffolds (biology) |
| description |
Porous scaffolds of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) were elaborated by three different techniques: salt leaching (SL), emulsion solvent evaporation (ESE) and temperature induced phase separation (TIPS). For SL partially fused sieved grains of sodium chloride (106-355 μm) were used as porogen. Emulsions, prepared from a solution of PHBV in chloroform allow getting flexible films; the content of surfactant may be used to control the pore size. The pore size of the TIPS scaffolds decreased on increasing the cooling rate and the morphology of the interconnected structure could be controlled by changing the temperature gradient. Finally, chemical changes associated to the enhancement of hydrophilic behaviour of the scaffolds after alkaline and enzymatic hydrolysis as well as after sterilization by γ irradiation are presented. |
| format |
CONF |
| author |
Ruiz, I. Hermida, É.B. Baldessari, A. |
| author_facet |
Ruiz, I. Hermida, É.B. Baldessari, A. |
| author_sort |
Ruiz, I. |
| title |
Fabrication and characterization of porous PHBV scaffolds for tissue engineering |
| title_short |
Fabrication and characterization of porous PHBV scaffolds for tissue engineering |
| title_full |
Fabrication and characterization of porous PHBV scaffolds for tissue engineering |
| title_fullStr |
Fabrication and characterization of porous PHBV scaffolds for tissue engineering |
| title_full_unstemmed |
Fabrication and characterization of porous PHBV scaffolds for tissue engineering |
| title_sort |
fabrication and characterization of porous phbv scaffolds for tissue engineering |
| url |
http://hdl.handle.net/20.500.12110/paper_17426588_v332_n1_p_Ruiz |
| work_keys_str_mv |
AT ruizi fabricationandcharacterizationofporousphbvscaffoldsfortissueengineering AT hermidaeb fabricationandcharacterizationofporousphbvscaffoldsfortissueengineering AT baldessaria fabricationandcharacterizationofporousphbvscaffoldsfortissueengineering |
| _version_ |
1807320866400239616 |