Electrochemotherapy in non-satisfactory responding tumors in vet patients: Combined administration of bleomycin, systemic and local

Electrochemotherapy (ECT), a medical treatment widely used in human tumor treatment, consists in the administration of bleomycin either systemically or locally followed by the application of an electric field. This procedure increases the toxicity of the bleomycin by 1000 fold in the treated area wi...

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Autores principales: Maglietti, F., Tellado, M., Olaiz, N., Michinski, S., Marshall, G., Kramar P., Jarm T.
Formato: CONF
Materias:
Bleomycin
Combined
Electrochemotherapy
Local systemic
Efficiency
Electric fields
Environmental technology
Patient treatment
Peptides
Bleomycins
Combined treatment
Complete response
Systemic administration
Tumor vascularization
Tumors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_16800737_v53_n_p445_Maglietti
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_16800737_v53_n_p445_Maglietti
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spelling todo:paper_16800737_v53_n_p445_Maglietti2023-10-03T16:29:49Z Electrochemotherapy in non-satisfactory responding tumors in vet patients: Combined administration of bleomycin, systemic and local Maglietti, F. Tellado, M. Olaiz, N. Michinski, S. Marshall, G. Kramar P. Jarm T. Bleomycin Combined Electrochemotherapy Local systemic Efficiency Electric fields Environmental technology Patient treatment Peptides Bleomycins Combined Combined treatment Complete response Electrochemotherapy Local systemic Systemic administration Tumor vascularization Tumors Electrochemotherapy (ECT), a medical treatment widely used in human tumor treatment, consists in the administration of bleomycin either systemically or locally followed by the application of an electric field. This procedure increases the toxicity of the bleomycin by 1000 fold in the treated area with an objective response rate of around 80%. Despite its success related to efficiency, low cost and minimum side effects, there is still a 20% of cases in which the ECT treatment is not responding. This could be ascribed to the fact that bleomycin, administered in the preferred way, that is, systemically for large tumors, is not properly reaching the whole tumor mass. The main cause is poor tumor vascularization, in which case local administration could cover areas unreachable with systemic administration. To address this problem here we propose the combined administration of bleomycin, systemic and locally, using companion animals as models for ECT tumor treating. Accordingly, we selected 7 canine and 2 feline patients with a single tumor with poor or no response to ECT, and then we repeat the treatment with ECT but now with a combined administration of bleomycin, systemic and local. The results show, according to an evaluation using the WHO criteria of tumor response, that from the 9 cases, 5 achieved a Complete Response, 3 a Partial Response, and 1 a Stable Disease after 30 days from the combined treatment date. In conclusion, the combined administration of bleomycin, systemic and local, in ECT could provide a good response in tumors that previously showed an unsatisfactory response. It is expected that these results could hopefully increase ECT efficiency. © Springer Science+Business Media Singapore 2016. CONF info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16800737_v53_n_p445_Maglietti
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Bleomycin
Combined
Electrochemotherapy
Local systemic
Efficiency
Electric fields
Environmental technology
Patient treatment
Peptides
Bleomycins
Combined
Combined treatment
Complete response
Electrochemotherapy
Local systemic
Systemic administration
Tumor vascularization
Tumors
spellingShingle Bleomycin
Combined
Electrochemotherapy
Local systemic
Efficiency
Electric fields
Environmental technology
Patient treatment
Peptides
Bleomycins
Combined
Combined treatment
Complete response
Electrochemotherapy
Local systemic
Systemic administration
Tumor vascularization
Tumors
Maglietti, F.
Tellado, M.
Olaiz, N.
Michinski, S.
Marshall, G.
Kramar P.
Jarm T.
Electrochemotherapy in non-satisfactory responding tumors in vet patients: Combined administration of bleomycin, systemic and local
topic_facet Bleomycin
Combined
Electrochemotherapy
Local systemic
Efficiency
Electric fields
Environmental technology
Patient treatment
Peptides
Bleomycins
Combined
Combined treatment
Complete response
Electrochemotherapy
Local systemic
Systemic administration
Tumor vascularization
Tumors
description Electrochemotherapy (ECT), a medical treatment widely used in human tumor treatment, consists in the administration of bleomycin either systemically or locally followed by the application of an electric field. This procedure increases the toxicity of the bleomycin by 1000 fold in the treated area with an objective response rate of around 80%. Despite its success related to efficiency, low cost and minimum side effects, there is still a 20% of cases in which the ECT treatment is not responding. This could be ascribed to the fact that bleomycin, administered in the preferred way, that is, systemically for large tumors, is not properly reaching the whole tumor mass. The main cause is poor tumor vascularization, in which case local administration could cover areas unreachable with systemic administration. To address this problem here we propose the combined administration of bleomycin, systemic and locally, using companion animals as models for ECT tumor treating. Accordingly, we selected 7 canine and 2 feline patients with a single tumor with poor or no response to ECT, and then we repeat the treatment with ECT but now with a combined administration of bleomycin, systemic and local. The results show, according to an evaluation using the WHO criteria of tumor response, that from the 9 cases, 5 achieved a Complete Response, 3 a Partial Response, and 1 a Stable Disease after 30 days from the combined treatment date. In conclusion, the combined administration of bleomycin, systemic and local, in ECT could provide a good response in tumors that previously showed an unsatisfactory response. It is expected that these results could hopefully increase ECT efficiency. © Springer Science+Business Media Singapore 2016.
format CONF
author Maglietti, F.
Tellado, M.
Olaiz, N.
Michinski, S.
Marshall, G.
Kramar P.
Jarm T.
author_facet Maglietti, F.
Tellado, M.
Olaiz, N.
Michinski, S.
Marshall, G.
Kramar P.
Jarm T.
author_sort Maglietti, F.
title Electrochemotherapy in non-satisfactory responding tumors in vet patients: Combined administration of bleomycin, systemic and local
title_short Electrochemotherapy in non-satisfactory responding tumors in vet patients: Combined administration of bleomycin, systemic and local
title_full Electrochemotherapy in non-satisfactory responding tumors in vet patients: Combined administration of bleomycin, systemic and local
title_fullStr Electrochemotherapy in non-satisfactory responding tumors in vet patients: Combined administration of bleomycin, systemic and local
title_full_unstemmed Electrochemotherapy in non-satisfactory responding tumors in vet patients: Combined administration of bleomycin, systemic and local
title_sort electrochemotherapy in non-satisfactory responding tumors in vet patients: combined administration of bleomycin, systemic and local
url http://hdl.handle.net/20.500.12110/paper_16800737_v53_n_p445_Maglietti
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AT olaizn electrochemotherapyinnonsatisfactoryrespondingtumorsinvetpatientscombinedadministrationofbleomycinsystemicandlocal
AT michinskis electrochemotherapyinnonsatisfactoryrespondingtumorsinvetpatientscombinedadministrationofbleomycinsystemicandlocal
AT marshallg electrochemotherapyinnonsatisfactoryrespondingtumorsinvetpatientscombinedadministrationofbleomycinsystemicandlocal
AT kramarp electrochemotherapyinnonsatisfactoryrespondingtumorsinvetpatientscombinedadministrationofbleomycinsystemicandlocal
AT jarmt electrochemotherapyinnonsatisfactoryrespondingtumorsinvetpatientscombinedadministrationofbleomycinsystemicandlocal
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