Target RNAs strike back on MicroRNAs

MicroRNAs are extensively studied regulatory non-coding small RNAs that silence animal genes throughout most biological processes, typically doing so by binding to partially complementary sequences within target RNAs. A plethora of studies has described detailed mechanisms for microRNA biogenesis an...

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Autores principales:	Wightman, F.F., Giono, L.E., Fededa, J.P., De La Mata, M.
Formato:	JOUR
Materias:	Argonaute Degradation Exoribonuclease MicroRNA Tailing And trimming TDMD Terminal nucleotidyl transferase Uridylation argonaute protein microRNA nucleotide RNA small untranslated RNA virus RNA 3' untranslated region binding site gene cluster gene expression regulation gene loss gene repression gene silencing gene targeting nonhuman Review RNA degradation tissue specificity
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_16648021_v9_nOCT_p_Wightman
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_16648021_v9_nOCT_p_Wightman2023-10-03T16:29:13Z Target RNAs strike back on MicroRNAs Wightman, F.F. Giono, L.E. Fededa, J.P. De La Mata, M. Argonaute Degradation Exoribonuclease MicroRNA Tailing And trimming TDMD Terminal nucleotidyl transferase Uridylation argonaute protein microRNA nucleotide RNA small untranslated RNA virus RNA 3' untranslated region binding site gene cluster gene expression regulation gene loss gene repression gene silencing gene targeting nonhuman Review RNA degradation tissue specificity MicroRNAs are extensively studied regulatory non-coding small RNAs that silence animal genes throughout most biological processes, typically doing so by binding to partially complementary sequences within target RNAs. A plethora of studies has described detailed mechanisms for microRNA biogenesis and function, as well as their temporal and spatial regulation during development. By inducing translational repression and/or degradation of their target RNAs, microRNAs can contribute to achieve highly specific cell-or tissue-specific gene expression, while their aberrant expression can lead to disease. Yet an unresolved aspect of microRNA biology is how such small RNA molecules are themselves cleared from the cell, especially under circumstances where fast microRNA turnover or specific degradation of individual microRNAs is required. In recent years, it was unexpectedly found that binding of specific target RNAs to microRNAs with extensive complementarity can reverse the outcome, triggering degradation of the bound microRNAs. This emerging pathway, named TDMD for Target RNA-Directed MicroRNA Degradation, leads to microRNA 3′-end tailing by the addition of A/U non-templated nucleotides, trimming or shortening from the 3′ end, and highly specific microRNA loss, providing a new layer of microRNA regulation. Originally described in flies and known to be triggered by viral RNAs, novel endogenous instances of TDMD have been uncovered and are now starting to be understood. Here, we review our current knowledge of this pathway and its potential role in the control and diversification of microRNA expression patterns. © 2018 Fuchs Wightman, Giono, Fededa and de la Mata. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16648021_v9_nOCT_p_Wightman
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Argonaute Degradation Exoribonuclease MicroRNA Tailing And trimming TDMD Terminal nucleotidyl transferase Uridylation argonaute protein microRNA nucleotide RNA small untranslated RNA virus RNA 3' untranslated region binding site gene cluster gene expression regulation gene loss gene repression gene silencing gene targeting nonhuman Review RNA degradation tissue specificity
spellingShingle	Argonaute Degradation Exoribonuclease MicroRNA Tailing And trimming TDMD Terminal nucleotidyl transferase Uridylation argonaute protein microRNA nucleotide RNA small untranslated RNA virus RNA 3' untranslated region binding site gene cluster gene expression regulation gene loss gene repression gene silencing gene targeting nonhuman Review RNA degradation tissue specificity Wightman, F.F. Giono, L.E. Fededa, J.P. De La Mata, M. Target RNAs strike back on MicroRNAs
topic_facet	Argonaute Degradation Exoribonuclease MicroRNA Tailing And trimming TDMD Terminal nucleotidyl transferase Uridylation argonaute protein microRNA nucleotide RNA small untranslated RNA virus RNA 3' untranslated region binding site gene cluster gene expression regulation gene loss gene repression gene silencing gene targeting nonhuman Review RNA degradation tissue specificity
description	MicroRNAs are extensively studied regulatory non-coding small RNAs that silence animal genes throughout most biological processes, typically doing so by binding to partially complementary sequences within target RNAs. A plethora of studies has described detailed mechanisms for microRNA biogenesis and function, as well as their temporal and spatial regulation during development. By inducing translational repression and/or degradation of their target RNAs, microRNAs can contribute to achieve highly specific cell-or tissue-specific gene expression, while their aberrant expression can lead to disease. Yet an unresolved aspect of microRNA biology is how such small RNA molecules are themselves cleared from the cell, especially under circumstances where fast microRNA turnover or specific degradation of individual microRNAs is required. In recent years, it was unexpectedly found that binding of specific target RNAs to microRNAs with extensive complementarity can reverse the outcome, triggering degradation of the bound microRNAs. This emerging pathway, named TDMD for Target RNA-Directed MicroRNA Degradation, leads to microRNA 3′-end tailing by the addition of A/U non-templated nucleotides, trimming or shortening from the 3′ end, and highly specific microRNA loss, providing a new layer of microRNA regulation. Originally described in flies and known to be triggered by viral RNAs, novel endogenous instances of TDMD have been uncovered and are now starting to be understood. Here, we review our current knowledge of this pathway and its potential role in the control and diversification of microRNA expression patterns. © 2018 Fuchs Wightman, Giono, Fededa and de la Mata.
format	JOUR
author	Wightman, F.F. Giono, L.E. Fededa, J.P. De La Mata, M.
author_facet	Wightman, F.F. Giono, L.E. Fededa, J.P. De La Mata, M.
author_sort	Wightman, F.F.
title	Target RNAs strike back on MicroRNAs
title_short	Target RNAs strike back on MicroRNAs
title_full	Target RNAs strike back on MicroRNAs
title_fullStr	Target RNAs strike back on MicroRNAs
title_full_unstemmed	Target RNAs strike back on MicroRNAs
title_sort	target rnas strike back on micrornas
url	http://hdl.handle.net/20.500.12110/paper_16648021_v9_nOCT_p_Wightman
work_keys_str_mv	AT wightmanff targetrnasstrikebackonmicrornas AT gionole targetrnasstrikebackonmicrornas AT fededajp targetrnasstrikebackonmicrornas AT delamatam targetrnasstrikebackonmicrornas
_version_	1807316575343083520

Target RNAs strike back on MicroRNAs

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