Pedunculopontine nucleus gamma band activity-preconscious awareness, waking, and REM sleep

The pedunculopontine nucleus (PPN) is a major component of the reticular activating system (RAS) that regulates waking and REM sleep, states of high frequency EEG activity. Recently, we described the presence of high threshold, voltage-dependent N- and P/Q-type calcium channels in RAS nuclei that su...

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Detalles Bibliográficos
Autores principales: Urbano, F.J., D'Onofrio, S., Luster, B., Beck, P., Hyde, J., Bisagno, V., Garcia-Rill, E.
Formato: JOUR
Materias:
Bipolar disorder
Calcium/calmodulin-dependent protein kinase II
Cyclic adenosine monophosphate
Leptin
N-and P/Q-type calcium channels
Neuronal calcium sensor
Schizophrenia
calcium channel N type
calcium channel P type
calcium channel Q type
cyclic AMP dependent protein kinase
leptin
neuronal calcium sensor
neuronal calcium sensor 1
unclassified drug
Article
awareness
bipolar disorder
calcium signaling
central nervous system
cognition
consciousness
contingent negative variation
executive function
food intake
free will
gamma rhythm
hallucination
hormonal regulation
human
memory
motor dysfunction
nerve cell network
nonhuman
obesity
oscillation
pedunculopontine tegmental nucleus
perception
preconscious awareness
problem solving
protein expression
REM sleep
reticular activating system
schizophrenia
sleep disorder
sleep waking cycle
slow wave sleep
synaptic transmission
voluntary movement
wakefulness
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_16642295_v5_nOCT_p_Urbano
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_16642295_v5_nOCT_p_Urbano
record_format dspace
spelling todo:paper_16642295_v5_nOCT_p_Urbano2023-10-03T16:29:03Z Pedunculopontine nucleus gamma band activity-preconscious awareness, waking, and REM sleep Urbano, F.J. D'Onofrio, S. Luster, B. Beck, P. Hyde, J. Bisagno, V. Garcia-Rill, E. Bipolar disorder Calcium/calmodulin-dependent protein kinase II Cyclic adenosine monophosphate Leptin N-and P/Q-type calcium channels Neuronal calcium sensor Schizophrenia calcium channel N type calcium channel P type calcium channel Q type cyclic AMP dependent protein kinase leptin neuronal calcium sensor neuronal calcium sensor 1 unclassified drug Article awareness bipolar disorder calcium signaling central nervous system cognition consciousness contingent negative variation executive function food intake free will gamma rhythm hallucination hormonal regulation human memory motor dysfunction nerve cell network nonhuman obesity oscillation pedunculopontine tegmental nucleus perception preconscious awareness problem solving protein expression REM sleep reticular activating system schizophrenia sleep disorder sleep waking cycle slow wave sleep synaptic transmission voluntary movement wakefulness The pedunculopontine nucleus (PPN) is a major component of the reticular activating system (RAS) that regulates waking and REM sleep, states of high frequency EEG activity. Recently, we described the presence of high threshold, voltage-dependent N- and P/Q-type calcium channels in RAS nuclei that subserve gamma band oscillations in the mesopontine pedunculopontine nucleus (PPN), intralaminar parafascicular nucleus (Pf), and pontine Subcoeruleus nucleus dorsalis (SubCD). Cortical gamma band activity participates in sensory perception, problem solving, and memory. Rather than participating in the temporal binding of sensory events as in the cortex, gamma band activity in the RAS may participate in the processes of preconscious awareness, and provide the essential stream of information for the formulation of many of our actions. That is, the RAS may play an early permissive role in volition. Our latest results suggest that, 1) the manifestation of gamma band activity during waking may employ a separate intracellular pathway compared to that during REM sleep, 2) neuronal calcium sensor (NCS-1) protein, which is over expressed in schizophrenia and bipolar disorder, modulates gamma band oscillations in the PPN in a concentration-dependent manner, 3) leptin, which undergoes resistance in obesity resulting in sleep dysregulation, decreases sodium currents in PPN neurons, accounting for its normal attenuation of waking, and 4) following our discovery of electrical coupling in the RAS, we hypothesize that there are cell clusters within the PPN that may act in concert. These results provide novel information on the mechanisms controlling high frequency activity related to waking and REM sleep by elements of the RAS. © 2014 Urbano, D_onofrio, Luster, Beck, Hyde, Bisagno and Garcia-rill. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16642295_v5_nOCT_p_Urbano
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Bipolar disorder
Calcium/calmodulin-dependent protein kinase II
Cyclic adenosine monophosphate
Leptin
N-and P/Q-type calcium channels
Neuronal calcium sensor
Schizophrenia
calcium channel N type
calcium channel P type
calcium channel Q type
cyclic AMP dependent protein kinase
leptin
neuronal calcium sensor
neuronal calcium sensor 1
unclassified drug
Article
awareness
bipolar disorder
calcium signaling
central nervous system
cognition
consciousness
contingent negative variation
executive function
food intake
free will
gamma rhythm
hallucination
hormonal regulation
human
memory
motor dysfunction
nerve cell network
nonhuman
obesity
oscillation
pedunculopontine tegmental nucleus
perception
preconscious awareness
problem solving
protein expression
REM sleep
reticular activating system
schizophrenia
sleep disorder
sleep waking cycle
slow wave sleep
synaptic transmission
voluntary movement
wakefulness
spellingShingle Bipolar disorder
Calcium/calmodulin-dependent protein kinase II
Cyclic adenosine monophosphate
Leptin
N-and P/Q-type calcium channels
Neuronal calcium sensor
Schizophrenia
calcium channel N type
calcium channel P type
calcium channel Q type
cyclic AMP dependent protein kinase
leptin
neuronal calcium sensor
neuronal calcium sensor 1
unclassified drug
Article
awareness
bipolar disorder
calcium signaling
central nervous system
cognition
consciousness
contingent negative variation
executive function
food intake
free will
gamma rhythm
hallucination
hormonal regulation
human
memory
motor dysfunction
nerve cell network
nonhuman
obesity
oscillation
pedunculopontine tegmental nucleus
perception
preconscious awareness
problem solving
protein expression
REM sleep
reticular activating system
schizophrenia
sleep disorder
sleep waking cycle
slow wave sleep
synaptic transmission
voluntary movement
wakefulness
Urbano, F.J.
D'Onofrio, S.
Luster, B.
Beck, P.
Hyde, J.
Bisagno, V.
Garcia-Rill, E.
Pedunculopontine nucleus gamma band activity-preconscious awareness, waking, and REM sleep
topic_facet Bipolar disorder
Calcium/calmodulin-dependent protein kinase II
Cyclic adenosine monophosphate
Leptin
N-and P/Q-type calcium channels
Neuronal calcium sensor
Schizophrenia
calcium channel N type
calcium channel P type
calcium channel Q type
cyclic AMP dependent protein kinase
leptin
neuronal calcium sensor
neuronal calcium sensor 1
unclassified drug
Article
awareness
bipolar disorder
calcium signaling
central nervous system
cognition
consciousness
contingent negative variation
executive function
food intake
free will
gamma rhythm
hallucination
hormonal regulation
human
memory
motor dysfunction
nerve cell network
nonhuman
obesity
oscillation
pedunculopontine tegmental nucleus
perception
preconscious awareness
problem solving
protein expression
REM sleep
reticular activating system
schizophrenia
sleep disorder
sleep waking cycle
slow wave sleep
synaptic transmission
voluntary movement
wakefulness
description The pedunculopontine nucleus (PPN) is a major component of the reticular activating system (RAS) that regulates waking and REM sleep, states of high frequency EEG activity. Recently, we described the presence of high threshold, voltage-dependent N- and P/Q-type calcium channels in RAS nuclei that subserve gamma band oscillations in the mesopontine pedunculopontine nucleus (PPN), intralaminar parafascicular nucleus (Pf), and pontine Subcoeruleus nucleus dorsalis (SubCD). Cortical gamma band activity participates in sensory perception, problem solving, and memory. Rather than participating in the temporal binding of sensory events as in the cortex, gamma band activity in the RAS may participate in the processes of preconscious awareness, and provide the essential stream of information for the formulation of many of our actions. That is, the RAS may play an early permissive role in volition. Our latest results suggest that, 1) the manifestation of gamma band activity during waking may employ a separate intracellular pathway compared to that during REM sleep, 2) neuronal calcium sensor (NCS-1) protein, which is over expressed in schizophrenia and bipolar disorder, modulates gamma band oscillations in the PPN in a concentration-dependent manner, 3) leptin, which undergoes resistance in obesity resulting in sleep dysregulation, decreases sodium currents in PPN neurons, accounting for its normal attenuation of waking, and 4) following our discovery of electrical coupling in the RAS, we hypothesize that there are cell clusters within the PPN that may act in concert. These results provide novel information on the mechanisms controlling high frequency activity related to waking and REM sleep by elements of the RAS. © 2014 Urbano, D_onofrio, Luster, Beck, Hyde, Bisagno and Garcia-rill.
format JOUR
author Urbano, F.J.
D'Onofrio, S.
Luster, B.
Beck, P.
Hyde, J.
Bisagno, V.
Garcia-Rill, E.
author_facet Urbano, F.J.
D'Onofrio, S.
Luster, B.
Beck, P.
Hyde, J.
Bisagno, V.
Garcia-Rill, E.
author_sort Urbano, F.J.
title Pedunculopontine nucleus gamma band activity-preconscious awareness, waking, and REM sleep
title_short Pedunculopontine nucleus gamma band activity-preconscious awareness, waking, and REM sleep
title_full Pedunculopontine nucleus gamma band activity-preconscious awareness, waking, and REM sleep
title_fullStr Pedunculopontine nucleus gamma band activity-preconscious awareness, waking, and REM sleep
title_full_unstemmed Pedunculopontine nucleus gamma band activity-preconscious awareness, waking, and REM sleep
title_sort pedunculopontine nucleus gamma band activity-preconscious awareness, waking, and rem sleep
url http://hdl.handle.net/20.500.12110/paper_16642295_v5_nOCT_p_Urbano
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