Dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats

Dopamine release and phase-amplitude cross-frequency coupling (CFC) have independently been implicated in prefrontal cortex (PFC) functioning. To causally investigate whether dopamine release affects phase-amplitude comodulation between different frequencies in local field potentials (LFP) recorded...

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Autores principales:	Andino-Pavlovsky, V., Souza, A.C., Scheffer-Teixeira, R., Tort, A.B.L., Etchenique, R., Ribeiro, S.
Formato:	JOUR
Materias:	Comodulation Delta-gamma coupling Dopamine LFP oscillation Uncaging dopamine rubidopa unclassified drug 2,2' bipyridine dichlorobis(2,2'-bipyridine)ruthenium organometallic compound action potential amplitude amplitude modulation animal behavior animal experiment animal tissue Article brain function controlled study delta oscillation dopamine release electric potential gamma oscillation light irradiance local field potential male medial prefrontal cortex nonhuman oscillation rat analogs and derivatives animal delta rhythm drug effects electroencephalography gamma rhythm metabolism photostimulation physiology prefrontal cortex procedures REM sleep spectroscopy time factor ultraviolet radiation wakefulness Wistar rat 2,2'-Dipyridyl Animals Delta Rhythm Electroencephalography Gamma Rhythm Male Organometallic Compounds Photic Stimulation Prefrontal Cortex Rats Rats, Wistar Sleep, REM Spectrum Analysis Time Factors Ultraviolet Rays Wakefulness
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_16625110_v11_n_p_AndinoPavlovsky
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_16625110_v11_n_p_AndinoPavlovsky
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spelling	todo:paper_16625110_v11_n_p_AndinoPavlovsky2023-10-03T16:28:47Z Dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats Andino-Pavlovsky, V. Souza, A.C. Scheffer-Teixeira, R. Tort, A.B.L. Etchenique, R. Ribeiro, S. Comodulation Delta-gamma coupling Dopamine LFP oscillation Uncaging dopamine rubidopa unclassified drug 2,2' bipyridine dichlorobis(2,2'-bipyridine)ruthenium dopamine organometallic compound action potential amplitude amplitude modulation animal behavior animal experiment animal tissue Article brain function controlled study delta oscillation dopamine release electric potential gamma oscillation light irradiance local field potential male medial prefrontal cortex nonhuman oscillation rat analogs and derivatives animal delta rhythm drug effects electroencephalography gamma rhythm metabolism photostimulation physiology prefrontal cortex procedures REM sleep spectroscopy time factor ultraviolet radiation wakefulness Wistar rat 2,2'-Dipyridyl Animals Delta Rhythm Dopamine Electroencephalography Gamma Rhythm Male Organometallic Compounds Photic Stimulation Prefrontal Cortex Rats Rats, Wistar Sleep, REM Spectrum Analysis Time Factors Ultraviolet Rays Wakefulness Dopamine release and phase-amplitude cross-frequency coupling (CFC) have independently been implicated in prefrontal cortex (PFC) functioning. To causally investigate whether dopamine release affects phase-amplitude comodulation between different frequencies in local field potentials (LFP) recorded from the medial PFC (mPFC) of behaving rats, we used RuBiDopa, a light-sensitive caged compound that releases the neurotransmitter dopamine when irradiated with visible light. LFP power did not change in any frequency band after the application of light-uncaged dopamine, but significantly strengthened phase-amplitude comodulation between delta and gamma oscillations. Saline did not exert significant changes, while injections of dopamine and RuBiDopa produced a slow increase in comodulation for several minutes after the injection. The results show that dopamine release in the medial PFC shifts phase-amplitude comodulation from theta-gamma to delta-gamma. Although being preliminary results due to the limitation of the low number of animals present in this study, our findings suggest that dopamine-mediated modification of the frequencies involved in comodulation could be a mechanism by which this neurotransmitter regulates functioning in mPFC. © 2017 Andino-Pavlovsky, Souza, Scheffer-Teixeira, Tort, Etchenique and Ribeiro. Fil:Etchenique, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16625110_v11_n_p_AndinoPavlovsky
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Comodulation Delta-gamma coupling Dopamine LFP oscillation Uncaging dopamine rubidopa unclassified drug 2,2' bipyridine dichlorobis(2,2'-bipyridine)ruthenium dopamine organometallic compound action potential amplitude amplitude modulation animal behavior animal experiment animal tissue Article brain function controlled study delta oscillation dopamine release electric potential gamma oscillation light irradiance local field potential male medial prefrontal cortex nonhuman oscillation rat analogs and derivatives animal delta rhythm drug effects electroencephalography gamma rhythm metabolism photostimulation physiology prefrontal cortex procedures REM sleep spectroscopy time factor ultraviolet radiation wakefulness Wistar rat 2,2'-Dipyridyl Animals Delta Rhythm Dopamine Electroencephalography Gamma Rhythm Male Organometallic Compounds Photic Stimulation Prefrontal Cortex Rats Rats, Wistar Sleep, REM Spectrum Analysis Time Factors Ultraviolet Rays Wakefulness
spellingShingle	Comodulation Delta-gamma coupling Dopamine LFP oscillation Uncaging dopamine rubidopa unclassified drug 2,2' bipyridine dichlorobis(2,2'-bipyridine)ruthenium dopamine organometallic compound action potential amplitude amplitude modulation animal behavior animal experiment animal tissue Article brain function controlled study delta oscillation dopamine release electric potential gamma oscillation light irradiance local field potential male medial prefrontal cortex nonhuman oscillation rat analogs and derivatives animal delta rhythm drug effects electroencephalography gamma rhythm metabolism photostimulation physiology prefrontal cortex procedures REM sleep spectroscopy time factor ultraviolet radiation wakefulness Wistar rat 2,2'-Dipyridyl Animals Delta Rhythm Dopamine Electroencephalography Gamma Rhythm Male Organometallic Compounds Photic Stimulation Prefrontal Cortex Rats Rats, Wistar Sleep, REM Spectrum Analysis Time Factors Ultraviolet Rays Wakefulness Andino-Pavlovsky, V. Souza, A.C. Scheffer-Teixeira, R. Tort, A.B.L. Etchenique, R. Ribeiro, S. Dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats
topic_facet	Comodulation Delta-gamma coupling Dopamine LFP oscillation Uncaging dopamine rubidopa unclassified drug 2,2' bipyridine dichlorobis(2,2'-bipyridine)ruthenium dopamine organometallic compound action potential amplitude amplitude modulation animal behavior animal experiment animal tissue Article brain function controlled study delta oscillation dopamine release electric potential gamma oscillation light irradiance local field potential male medial prefrontal cortex nonhuman oscillation rat analogs and derivatives animal delta rhythm drug effects electroencephalography gamma rhythm metabolism photostimulation physiology prefrontal cortex procedures REM sleep spectroscopy time factor ultraviolet radiation wakefulness Wistar rat 2,2'-Dipyridyl Animals Delta Rhythm Dopamine Electroencephalography Gamma Rhythm Male Organometallic Compounds Photic Stimulation Prefrontal Cortex Rats Rats, Wistar Sleep, REM Spectrum Analysis Time Factors Ultraviolet Rays Wakefulness
description	Dopamine release and phase-amplitude cross-frequency coupling (CFC) have independently been implicated in prefrontal cortex (PFC) functioning. To causally investigate whether dopamine release affects phase-amplitude comodulation between different frequencies in local field potentials (LFP) recorded from the medial PFC (mPFC) of behaving rats, we used RuBiDopa, a light-sensitive caged compound that releases the neurotransmitter dopamine when irradiated with visible light. LFP power did not change in any frequency band after the application of light-uncaged dopamine, but significantly strengthened phase-amplitude comodulation between delta and gamma oscillations. Saline did not exert significant changes, while injections of dopamine and RuBiDopa produced a slow increase in comodulation for several minutes after the injection. The results show that dopamine release in the medial PFC shifts phase-amplitude comodulation from theta-gamma to delta-gamma. Although being preliminary results due to the limitation of the low number of animals present in this study, our findings suggest that dopamine-mediated modification of the frequencies involved in comodulation could be a mechanism by which this neurotransmitter regulates functioning in mPFC. © 2017 Andino-Pavlovsky, Souza, Scheffer-Teixeira, Tort, Etchenique and Ribeiro.
format	JOUR
author	Andino-Pavlovsky, V. Souza, A.C. Scheffer-Teixeira, R. Tort, A.B.L. Etchenique, R. Ribeiro, S.
author_facet	Andino-Pavlovsky, V. Souza, A.C. Scheffer-Teixeira, R. Tort, A.B.L. Etchenique, R. Ribeiro, S.
author_sort	Andino-Pavlovsky, V.
title	Dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats
title_short	Dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats
title_full	Dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats
title_fullStr	Dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats
title_full_unstemmed	Dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats
title_sort	dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats
url	http://hdl.handle.net/20.500.12110/paper_16625110_v11_n_p_AndinoPavlovsky
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Dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats

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