ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory

Extracellular regulated kinase 1/2 (ERK1/2) has been strongly implicated in several cellular processes. In the brain ERK1/2 activity has been primarily involved in long-term memory (LTM) formation and expression. Here, we review earlier evidence and describe recent developments of ERK1/2 signaling i...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Medina, J.H., Viola, H.
Formato: JOUR
Materias:
Durability
ERK1/2
Extinction
Long-term memory
Reconsolidation
Retrieval
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_16625099_v11_n_p_Medina
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_16625099_v11_n_p_Medina
record_format dspace
spelling todo:paper_16625099_v11_n_p_Medina2023-10-03T16:28:44Z ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory Medina, J.H. Viola, H. Durability ERK1/2 Extinction Long-term memory Reconsolidation Retrieval Extracellular regulated kinase 1/2 (ERK1/2) has been strongly implicated in several cellular processes. In the brain ERK1/2 activity has been primarily involved in long-term memory (LTM) formation and expression. Here, we review earlier evidence and describe recent developments of ERK1/2 signaling in memory processing focusing the attention on the role of ERK1/2 in memory retrieval and reconsolidation, and in the maintenance of the memory trace including mechanisms involving the protection of labile memories. In addition, relearning requires ERK1/2 activity in selected brain regions. Its involvement in distinct memory stages points at ERK1/2 as a core element in memory processing and as one likely target to treat memory impairments associated with neurological disorders. © 2018 Medina and Viola. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16625099_v11_n_p_Medina
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Durability
ERK1/2
Extinction
Long-term memory
Reconsolidation
Retrieval
spellingShingle Durability
ERK1/2
Extinction
Long-term memory
Reconsolidation
Retrieval
Medina, J.H.
Viola, H.
ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
topic_facet Durability
ERK1/2
Extinction
Long-term memory
Reconsolidation
Retrieval
description Extracellular regulated kinase 1/2 (ERK1/2) has been strongly implicated in several cellular processes. In the brain ERK1/2 activity has been primarily involved in long-term memory (LTM) formation and expression. Here, we review earlier evidence and describe recent developments of ERK1/2 signaling in memory processing focusing the attention on the role of ERK1/2 in memory retrieval and reconsolidation, and in the maintenance of the memory trace including mechanisms involving the protection of labile memories. In addition, relearning requires ERK1/2 activity in selected brain regions. Its involvement in distinct memory stages points at ERK1/2 as a core element in memory processing and as one likely target to treat memory impairments associated with neurological disorders. © 2018 Medina and Viola.
format JOUR
author Medina, J.H.
Viola, H.
author_facet Medina, J.H.
Viola, H.
author_sort Medina, J.H.
title ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
title_short ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
title_full ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
title_fullStr ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
title_full_unstemmed ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
title_sort erk1/2: a key cellular component for the formation, retrieval, reconsolidation and persistence of memory
url http://hdl.handle.net/20.500.12110/paper_16625099_v11_n_p_Medina
work_keys_str_mv AT medinajh erk12akeycellularcomponentfortheformationretrievalreconsolidationandpersistenceofmemory
AT violah erk12akeycellularcomponentfortheformationretrievalreconsolidationandpersistenceofmemory
_version_ 1807324023479074816

Ejemplares similares