Altered gene expression in hippocampus and depressive-like behavior in young adult female mice by early protein malnutrition
Perinatal development represents a critical period in the life of an individual. A common cause of poor development is that which comes from undernutrition or malnutrition. In particular, protein deprivation during development has been shown to have deep deleterious effects on brain's growth an...
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todo:paper_16011848_v15_n8_p741_Belluscio2023-10-03T16:27:49Z Altered gene expression in hippocampus and depressive-like behavior in young adult female mice by early protein malnutrition Belluscio, L.M. Alberca, C.D. Pregi, N. Cánepa, E.T. c-fos Calcineurin depressive-like behavior early-life stress Egr1 forced swimming test hippocampus malnutrition mice perinatal period calcineurin early growth response factor 1 protein c fos adult animal experiment animal model Article behavior controlled study coping behavior depression female forced swim test gene expression hippocampus kwashiorkor malnutrition mouse nerve cell plasticity nonhuman priority journal animal animal behavior anxiety depression disease model gene expression genetics hippocampus male mental stress metabolism pathophysiology physiology pregnancy protein calorie malnutrition psychology Adaptation, Psychological Animals Anxiety Behavior, Animal Depression Depressive Disorder Disease Models, Animal Female Gene Expression Hippocampus Male Mice Neuronal Plasticity Pregnancy Protein-Energy Malnutrition Stress, Psychological Perinatal development represents a critical period in the life of an individual. A common cause of poor development is that which comes from undernutrition or malnutrition. In particular, protein deprivation during development has been shown to have deep deleterious effects on brain's growth and plasticity. Early-life stress has also been linked with an increased risk to develop different psychopathologies later in life. We have previously shown that perinatal protein malnutrition in mice leads to the appearance of anxiety-related behaviors in the adulthood. We also found evidence that the female offspring was more susceptible to the development of depression-related behaviors. In the present work, we further investigated this behavior together with its molecular bases. We focused our study on the hippocampus, as it is a structure involved in coping with stressful situations. We found an increase in immobility time in the forced swimming test in perinatally malnourished females, and an alteration in the expression of genes related with neuroplasticity, early growth response 1, calcineurin and c-fos. We also found that perinatal malnutrition causes a reduction in the number of neurons in the hippocampus. This reduction, together with altered gene expression, could be related to the increment in immobility time observed in the forced swimming test. © 2016 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society Fil:Pregi, N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cánepa, E.T. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16011848_v15_n8_p741_Belluscio |
| institution |
Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
c-fos Calcineurin depressive-like behavior early-life stress Egr1 forced swimming test hippocampus malnutrition mice perinatal period calcineurin early growth response factor 1 protein c fos adult animal experiment animal model Article behavior controlled study coping behavior depression female forced swim test gene expression hippocampus kwashiorkor malnutrition mouse nerve cell plasticity nonhuman priority journal animal animal behavior anxiety depression disease model gene expression genetics hippocampus male mental stress metabolism pathophysiology physiology pregnancy protein calorie malnutrition psychology Adaptation, Psychological Animals Anxiety Behavior, Animal Depression Depressive Disorder Disease Models, Animal Female Gene Expression Hippocampus Male Mice Neuronal Plasticity Pregnancy Protein-Energy Malnutrition Stress, Psychological |
| spellingShingle |
c-fos Calcineurin depressive-like behavior early-life stress Egr1 forced swimming test hippocampus malnutrition mice perinatal period calcineurin early growth response factor 1 protein c fos adult animal experiment animal model Article behavior controlled study coping behavior depression female forced swim test gene expression hippocampus kwashiorkor malnutrition mouse nerve cell plasticity nonhuman priority journal animal animal behavior anxiety depression disease model gene expression genetics hippocampus male mental stress metabolism pathophysiology physiology pregnancy protein calorie malnutrition psychology Adaptation, Psychological Animals Anxiety Behavior, Animal Depression Depressive Disorder Disease Models, Animal Female Gene Expression Hippocampus Male Mice Neuronal Plasticity Pregnancy Protein-Energy Malnutrition Stress, Psychological Belluscio, L.M. Alberca, C.D. Pregi, N. Cánepa, E.T. Altered gene expression in hippocampus and depressive-like behavior in young adult female mice by early protein malnutrition |
| topic_facet |
c-fos Calcineurin depressive-like behavior early-life stress Egr1 forced swimming test hippocampus malnutrition mice perinatal period calcineurin early growth response factor 1 protein c fos adult animal experiment animal model Article behavior controlled study coping behavior depression female forced swim test gene expression hippocampus kwashiorkor malnutrition mouse nerve cell plasticity nonhuman priority journal animal animal behavior anxiety depression disease model gene expression genetics hippocampus male mental stress metabolism pathophysiology physiology pregnancy protein calorie malnutrition psychology Adaptation, Psychological Animals Anxiety Behavior, Animal Depression Depressive Disorder Disease Models, Animal Female Gene Expression Hippocampus Male Mice Neuronal Plasticity Pregnancy Protein-Energy Malnutrition Stress, Psychological |
| description |
Perinatal development represents a critical period in the life of an individual. A common cause of poor development is that which comes from undernutrition or malnutrition. In particular, protein deprivation during development has been shown to have deep deleterious effects on brain's growth and plasticity. Early-life stress has also been linked with an increased risk to develop different psychopathologies later in life. We have previously shown that perinatal protein malnutrition in mice leads to the appearance of anxiety-related behaviors in the adulthood. We also found evidence that the female offspring was more susceptible to the development of depression-related behaviors. In the present work, we further investigated this behavior together with its molecular bases. We focused our study on the hippocampus, as it is a structure involved in coping with stressful situations. We found an increase in immobility time in the forced swimming test in perinatally malnourished females, and an alteration in the expression of genes related with neuroplasticity, early growth response 1, calcineurin and c-fos. We also found that perinatal malnutrition causes a reduction in the number of neurons in the hippocampus. This reduction, together with altered gene expression, could be related to the increment in immobility time observed in the forced swimming test. © 2016 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society |
| format |
JOUR |
| author |
Belluscio, L.M. Alberca, C.D. Pregi, N. Cánepa, E.T. |
| author_facet |
Belluscio, L.M. Alberca, C.D. Pregi, N. Cánepa, E.T. |
| author_sort |
Belluscio, L.M. |
| title |
Altered gene expression in hippocampus and depressive-like behavior in young adult female mice by early protein malnutrition |
| title_short |
Altered gene expression in hippocampus and depressive-like behavior in young adult female mice by early protein malnutrition |
| title_full |
Altered gene expression in hippocampus and depressive-like behavior in young adult female mice by early protein malnutrition |
| title_fullStr |
Altered gene expression in hippocampus and depressive-like behavior in young adult female mice by early protein malnutrition |
| title_full_unstemmed |
Altered gene expression in hippocampus and depressive-like behavior in young adult female mice by early protein malnutrition |
| title_sort |
altered gene expression in hippocampus and depressive-like behavior in young adult female mice by early protein malnutrition |
| url |
http://hdl.handle.net/20.500.12110/paper_16011848_v15_n8_p741_Belluscio |
| work_keys_str_mv |
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