Molecular mechanisms of glucocorticoids action: From basic research to clinical implications
Glucocorticoid (GCs) hormones have pleiotropic activities in the body playing important roles in metabolism and modulating/regulating the stress and immune responses. Upon stimuli that trigger immune or inflammatory responses there is a concomitant activation of the hypothalamus-pituitary-adrenal ax...
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todo:paper_15733955_v6_n4_p371_Liberman2023-10-03T16:27:36Z Molecular mechanisms of glucocorticoids action: From basic research to clinical implications Liberman, A.C. Castro, C.N. Noguerol, M.A. Tabarrozzi, A.E.B. Druker, J. Perone, M.J. Arzt, E. Glucocorticoids Inflammation Molecular interaction Transcription factors aziridine derivative BRG1 protein coactivator associated arginine methyltransferase 1 compound a corticosteroid derivative cyclic AMP responsive element binding protein binding protein deoxyribonuclease I glucocorticoid glucocorticoid receptor histone acetyltransferase immunoglobulin enhancer binding protein methyltransferase mitogen activated protein kinase nuclear receptor coactivator 2 phenylethanolamine n methyltransferase phosphatidylinositol 3 kinase phosphoenolpyruvate carboxykinase (GTP) protein kinase B protein p300 ru 24858 steroid receptor coactivator 1 transcription factor AP 1 tyrosine aminotransferase unclassified drug antiinflammatory activity article cellular immunity chronic inflammation conformational transition DNA binding drug mechanism gene expression regulation gene induction gene repression genetic transcription hormone responsive element human hypothalamus hypophysis adrenal system immune system inflammatory disease molecular biology priority journal protein DNA interaction protein protein interaction transactivation transcription regulation Glucocorticoid (GCs) hormones have pleiotropic activities in the body playing important roles in metabolism and modulating/regulating the stress and immune responses. Upon stimuli that trigger immune or inflammatory responses there is a concomitant activation of the hypothalamus-pituitary-adrenal axis ultimately manifested by an increase in the synthesis and release of GCs to the systemic circulation. GCs play a pivotal role in the interface between the neuroendocrine and immune systems by modulating the final outcome of the immune response. The successful resolution of an immune response depends on the fine tune interplay between GCs and cytokines. The interaction between intracellular signals elicited by cytokines and the activated glucocorticoid receptor (GR) results in the induction or repression of gene transcription coordinating an effective immune response, and then its resolution avoiding excessive deleterious reactions. Herein, we describe recent knowledge regarding basic research in the complex interaction between GCs and components of the immune system at cellular and molecular levels, as well as their clinical implications for health and disease. The benefits of therapeutic GCs controlling immune disorders as well as their misconduct are also discussed in terms of considering the benefits and adverse effects to control disease and inflammation. © 2010 Bentham Science Publishers Ltd. Fil:Liberman, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Castro, C.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Druker, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_15733955_v6_n4_p371_Liberman |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Glucocorticoids Inflammation Molecular interaction Transcription factors aziridine derivative BRG1 protein coactivator associated arginine methyltransferase 1 compound a corticosteroid derivative cyclic AMP responsive element binding protein binding protein deoxyribonuclease I glucocorticoid glucocorticoid receptor histone acetyltransferase immunoglobulin enhancer binding protein methyltransferase mitogen activated protein kinase nuclear receptor coactivator 2 phenylethanolamine n methyltransferase phosphatidylinositol 3 kinase phosphoenolpyruvate carboxykinase (GTP) protein kinase B protein p300 ru 24858 steroid receptor coactivator 1 transcription factor AP 1 tyrosine aminotransferase unclassified drug antiinflammatory activity article cellular immunity chronic inflammation conformational transition DNA binding drug mechanism gene expression regulation gene induction gene repression genetic transcription hormone responsive element human hypothalamus hypophysis adrenal system immune system inflammatory disease molecular biology priority journal protein DNA interaction protein protein interaction transactivation transcription regulation |
| spellingShingle |
Glucocorticoids Inflammation Molecular interaction Transcription factors aziridine derivative BRG1 protein coactivator associated arginine methyltransferase 1 compound a corticosteroid derivative cyclic AMP responsive element binding protein binding protein deoxyribonuclease I glucocorticoid glucocorticoid receptor histone acetyltransferase immunoglobulin enhancer binding protein methyltransferase mitogen activated protein kinase nuclear receptor coactivator 2 phenylethanolamine n methyltransferase phosphatidylinositol 3 kinase phosphoenolpyruvate carboxykinase (GTP) protein kinase B protein p300 ru 24858 steroid receptor coactivator 1 transcription factor AP 1 tyrosine aminotransferase unclassified drug antiinflammatory activity article cellular immunity chronic inflammation conformational transition DNA binding drug mechanism gene expression regulation gene induction gene repression genetic transcription hormone responsive element human hypothalamus hypophysis adrenal system immune system inflammatory disease molecular biology priority journal protein DNA interaction protein protein interaction transactivation transcription regulation Liberman, A.C. Castro, C.N. Noguerol, M.A. Tabarrozzi, A.E.B. Druker, J. Perone, M.J. Arzt, E. Molecular mechanisms of glucocorticoids action: From basic research to clinical implications |
| topic_facet |
Glucocorticoids Inflammation Molecular interaction Transcription factors aziridine derivative BRG1 protein coactivator associated arginine methyltransferase 1 compound a corticosteroid derivative cyclic AMP responsive element binding protein binding protein deoxyribonuclease I glucocorticoid glucocorticoid receptor histone acetyltransferase immunoglobulin enhancer binding protein methyltransferase mitogen activated protein kinase nuclear receptor coactivator 2 phenylethanolamine n methyltransferase phosphatidylinositol 3 kinase phosphoenolpyruvate carboxykinase (GTP) protein kinase B protein p300 ru 24858 steroid receptor coactivator 1 transcription factor AP 1 tyrosine aminotransferase unclassified drug antiinflammatory activity article cellular immunity chronic inflammation conformational transition DNA binding drug mechanism gene expression regulation gene induction gene repression genetic transcription hormone responsive element human hypothalamus hypophysis adrenal system immune system inflammatory disease molecular biology priority journal protein DNA interaction protein protein interaction transactivation transcription regulation |
| description |
Glucocorticoid (GCs) hormones have pleiotropic activities in the body playing important roles in metabolism and modulating/regulating the stress and immune responses. Upon stimuli that trigger immune or inflammatory responses there is a concomitant activation of the hypothalamus-pituitary-adrenal axis ultimately manifested by an increase in the synthesis and release of GCs to the systemic circulation. GCs play a pivotal role in the interface between the neuroendocrine and immune systems by modulating the final outcome of the immune response. The successful resolution of an immune response depends on the fine tune interplay between GCs and cytokines. The interaction between intracellular signals elicited by cytokines and the activated glucocorticoid receptor (GR) results in the induction or repression of gene transcription coordinating an effective immune response, and then its resolution avoiding excessive deleterious reactions. Herein, we describe recent knowledge regarding basic research in the complex interaction between GCs and components of the immune system at cellular and molecular levels, as well as their clinical implications for health and disease. The benefits of therapeutic GCs controlling immune disorders as well as their misconduct are also discussed in terms of considering the benefits and adverse effects to control disease and inflammation. © 2010 Bentham Science Publishers Ltd. |
| format |
JOUR |
| author |
Liberman, A.C. Castro, C.N. Noguerol, M.A. Tabarrozzi, A.E.B. Druker, J. Perone, M.J. Arzt, E. |
| author_facet |
Liberman, A.C. Castro, C.N. Noguerol, M.A. Tabarrozzi, A.E.B. Druker, J. Perone, M.J. Arzt, E. |
| author_sort |
Liberman, A.C. |
| title |
Molecular mechanisms of glucocorticoids action: From basic research to clinical implications |
| title_short |
Molecular mechanisms of glucocorticoids action: From basic research to clinical implications |
| title_full |
Molecular mechanisms of glucocorticoids action: From basic research to clinical implications |
| title_fullStr |
Molecular mechanisms of glucocorticoids action: From basic research to clinical implications |
| title_full_unstemmed |
Molecular mechanisms of glucocorticoids action: From basic research to clinical implications |
| title_sort |
molecular mechanisms of glucocorticoids action: from basic research to clinical implications |
| url |
http://hdl.handle.net/20.500.12110/paper_15733955_v6_n4_p371_Liberman |
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