Galectins: Major signaling modulators inside and outside the cell
Galectins control cell behavior by acting on different signaling pathways. Most of the biological activities ascribed to these molecules rely upon recognition of extracellular glycoconjugates and establishment of multivalente interactions, which trigger adaptive biological responses. However, galect...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_15665240_v14_n5_p630_Compagno |
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todo:paper_15665240_v14_n5_p630_Compagno2023-10-03T16:26:28Z Galectins: Major signaling modulators inside and outside the cell Compagno, D. Jaworski, F.M. Gentilini, L. Contrufo, G. Pérez, I.G. Elola, M.T. Pregi, N. Rabinovich, G.A. Laderach, D.J. Apoptosis Cell adherence Galectins Immune regulation Oncogenesis Signaling pathways CD45 antigen CD98 antigen galectin glycoconjugate immunoglobulin enhancer binding protein protein bcl 2 Ras protein Smad3 protein stress activated protein kinase galectin apoptosis cell migration cell proliferation downregulation gene control human nuclear localization signal protein expression protein localization protein phosphorylation protein processing review signal transduction spliceosome T lymphocyte tandem repeat animal carcinogenesis cell adhesion metabolism physiology Animals Carcinogenesis Cell Adhesion Galectins Humans Signal Transduction Galectins control cell behavior by acting on different signaling pathways. Most of the biological activities ascribed to these molecules rely upon recognition of extracellular glycoconjugates and establishment of multivalente interactions, which trigger adaptive biological responses. However, galectins are also detected within the cell in different compartments, where their regulatory functions still remain poorly understood. A deeper understanding of the entire galectin signalosome and its impact in cell behavior is therefore essential in order to delineate new strategies to specifically manipulate both galectin expression and function. This review summarizes our current knowledge of the signaling pathways activated by galectins, their glycan dependence and the cellular compartment where they become activated and are biologically relevant. © 2014 Bentham Science Publishers. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_15665240_v14_n5_p630_Compagno |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Apoptosis Cell adherence Galectins Immune regulation Oncogenesis Signaling pathways CD45 antigen CD98 antigen galectin glycoconjugate immunoglobulin enhancer binding protein protein bcl 2 Ras protein Smad3 protein stress activated protein kinase galectin apoptosis cell migration cell proliferation downregulation gene control human nuclear localization signal protein expression protein localization protein phosphorylation protein processing review signal transduction spliceosome T lymphocyte tandem repeat animal carcinogenesis cell adhesion metabolism physiology Animals Carcinogenesis Cell Adhesion Galectins Humans Signal Transduction |
| spellingShingle |
Apoptosis Cell adherence Galectins Immune regulation Oncogenesis Signaling pathways CD45 antigen CD98 antigen galectin glycoconjugate immunoglobulin enhancer binding protein protein bcl 2 Ras protein Smad3 protein stress activated protein kinase galectin apoptosis cell migration cell proliferation downregulation gene control human nuclear localization signal protein expression protein localization protein phosphorylation protein processing review signal transduction spliceosome T lymphocyte tandem repeat animal carcinogenesis cell adhesion metabolism physiology Animals Carcinogenesis Cell Adhesion Galectins Humans Signal Transduction Compagno, D. Jaworski, F.M. Gentilini, L. Contrufo, G. Pérez, I.G. Elola, M.T. Pregi, N. Rabinovich, G.A. Laderach, D.J. Galectins: Major signaling modulators inside and outside the cell |
| topic_facet |
Apoptosis Cell adherence Galectins Immune regulation Oncogenesis Signaling pathways CD45 antigen CD98 antigen galectin glycoconjugate immunoglobulin enhancer binding protein protein bcl 2 Ras protein Smad3 protein stress activated protein kinase galectin apoptosis cell migration cell proliferation downregulation gene control human nuclear localization signal protein expression protein localization protein phosphorylation protein processing review signal transduction spliceosome T lymphocyte tandem repeat animal carcinogenesis cell adhesion metabolism physiology Animals Carcinogenesis Cell Adhesion Galectins Humans Signal Transduction |
| description |
Galectins control cell behavior by acting on different signaling pathways. Most of the biological activities ascribed to these molecules rely upon recognition of extracellular glycoconjugates and establishment of multivalente interactions, which trigger adaptive biological responses. However, galectins are also detected within the cell in different compartments, where their regulatory functions still remain poorly understood. A deeper understanding of the entire galectin signalosome and its impact in cell behavior is therefore essential in order to delineate new strategies to specifically manipulate both galectin expression and function. This review summarizes our current knowledge of the signaling pathways activated by galectins, their glycan dependence and the cellular compartment where they become activated and are biologically relevant. © 2014 Bentham Science Publishers. |
| format |
JOUR |
| author |
Compagno, D. Jaworski, F.M. Gentilini, L. Contrufo, G. Pérez, I.G. Elola, M.T. Pregi, N. Rabinovich, G.A. Laderach, D.J. |
| author_facet |
Compagno, D. Jaworski, F.M. Gentilini, L. Contrufo, G. Pérez, I.G. Elola, M.T. Pregi, N. Rabinovich, G.A. Laderach, D.J. |
| author_sort |
Compagno, D. |
| title |
Galectins: Major signaling modulators inside and outside the cell |
| title_short |
Galectins: Major signaling modulators inside and outside the cell |
| title_full |
Galectins: Major signaling modulators inside and outside the cell |
| title_fullStr |
Galectins: Major signaling modulators inside and outside the cell |
| title_full_unstemmed |
Galectins: Major signaling modulators inside and outside the cell |
| title_sort |
galectins: major signaling modulators inside and outside the cell |
| url |
http://hdl.handle.net/20.500.12110/paper_15665240_v14_n5_p630_Compagno |
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