When chromatin meets splicing
Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key r...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_15459993_v16_n9_p902_Kornblihtt |
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todo:paper_15459993_v16_n9_p902_Kornblihtt2023-10-03T16:23:06Z When chromatin meets splicing Kornblihtt, A.R. Schor, I.E. Allo, M. Blencowe, B.J. alternative RNA splicing bioinformatics chromatin DNA sequence exon genome genome analysis human intron molecular recognition nonhuman nucleosome priority journal regulatory mechanism short survey Alternative Splicing Animals Base Composition Chromatin Exons Humans Introns RNA Precursors Transcription, Genetic Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key role in exon recognition at the pre-mRNA level during co-transcriptional splicing, consistent with previous findings indicating chromatin-mediated regulation of alternative splicing. © 2009 Nature America, Inc. All rights reserved. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Schor, I.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Allo, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_15459993_v16_n9_p902_Kornblihtt |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
alternative RNA splicing bioinformatics chromatin DNA sequence exon genome genome analysis human intron molecular recognition nonhuman nucleosome priority journal regulatory mechanism short survey Alternative Splicing Animals Base Composition Chromatin Exons Humans Introns RNA Precursors Transcription, Genetic |
| spellingShingle |
alternative RNA splicing bioinformatics chromatin DNA sequence exon genome genome analysis human intron molecular recognition nonhuman nucleosome priority journal regulatory mechanism short survey Alternative Splicing Animals Base Composition Chromatin Exons Humans Introns RNA Precursors Transcription, Genetic Kornblihtt, A.R. Schor, I.E. Allo, M. Blencowe, B.J. When chromatin meets splicing |
| topic_facet |
alternative RNA splicing bioinformatics chromatin DNA sequence exon genome genome analysis human intron molecular recognition nonhuman nucleosome priority journal regulatory mechanism short survey Alternative Splicing Animals Base Composition Chromatin Exons Humans Introns RNA Precursors Transcription, Genetic |
| description |
Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key role in exon recognition at the pre-mRNA level during co-transcriptional splicing, consistent with previous findings indicating chromatin-mediated regulation of alternative splicing. © 2009 Nature America, Inc. All rights reserved. |
| format |
JOUR |
| author |
Kornblihtt, A.R. Schor, I.E. Allo, M. Blencowe, B.J. |
| author_facet |
Kornblihtt, A.R. Schor, I.E. Allo, M. Blencowe, B.J. |
| author_sort |
Kornblihtt, A.R. |
| title |
When chromatin meets splicing |
| title_short |
When chromatin meets splicing |
| title_full |
When chromatin meets splicing |
| title_fullStr |
When chromatin meets splicing |
| title_full_unstemmed |
When chromatin meets splicing |
| title_sort |
when chromatin meets splicing |
| url |
http://hdl.handle.net/20.500.12110/paper_15459993_v16_n9_p902_Kornblihtt |
| work_keys_str_mv |
AT kornblihttar whenchromatinmeetssplicing AT schorie whenchromatinmeetssplicing AT allom whenchromatinmeetssplicing AT blencowebj whenchromatinmeetssplicing |
| _version_ |
1807323725395132416 |