A population-based study of retinoblastoma incidence and survival in Argentine children

Background: An increased incidence of retinoblastoma in some developing countries has been reported but no conclusive data are available from population-based studies at national level. Purpose: To report the incidence and survival of retinoblastoma in Argentina from the National Pediatric Cancer Re...

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Autores principales:	Moreno, F., Sinaki, B., Fandiño, A., Dussel, V., Orellana, L., Chantada, G.
Formato:	JOUR
Materias:	Cancer Children Retinoblastoma Survival adolescent Argentina article cancer incidence cancer survival child developed country female human major clinical study male mortality preschool child priority journal resident retinoblastoma school child socioeconomics tertiary care center cancer children survival Adolescent Child Child, Preschool Cohort Studies Female Follow-Up Studies Humans Incidence Infant Infant, Newborn Male Prognosis Registries Retinal Neoplasms Survival Rate
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_15455009_v61_n9_p1610_Moreno
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_15455009_v61_n9_p1610_Moreno
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spelling	todo:paper_15455009_v61_n9_p1610_Moreno2023-10-03T16:23:01Z A population-based study of retinoblastoma incidence and survival in Argentine children Moreno, F. Sinaki, B. Fandiño, A. Dussel, V. Orellana, L. Chantada, G. Cancer Children Retinoblastoma Survival adolescent Argentina article cancer incidence cancer survival child developed country female human major clinical study male mortality preschool child priority journal resident retinoblastoma school child socioeconomics tertiary care center cancer children retinoblastoma survival Adolescent Argentina Child Child, Preschool Cohort Studies Female Follow-Up Studies Humans Incidence Infant Infant, Newborn Male Prognosis Registries Retinal Neoplasms Retinoblastoma Survival Rate Background: An increased incidence of retinoblastoma in some developing countries has been reported but no conclusive data are available from population-based studies at national level. Purpose: To report the incidence and survival of retinoblastoma in Argentina from the National Pediatric Cancer Registry (ROHA) and the influence of socio-economical indicators on outcome. Procedure: Cases reported to the ROHA (2000-2009) were analyzed. Incidence rates were calculated using National Vital Statistics and survival was estimated. The extended human development index (EHDI) was used as a socio-economical indicator. Results: With 438 patients reported, an incidence of 5.0 cases per million children 0-14 years old (95% CI 3.5-6.4) was calculated. Median age at diagnosis was significantly higher for children from provinces with lower EHDI; (24 vs. 35 months for unilateral, (P=0.003) and 9 versus 11.5 months for bilateral retinoblastoma (P=0.027). The 3-year probability of survival was 0.87 and 0.94 for unilateral and bilateral retinoblastoma, respectively. Residents in provinces with higher EHDI had a better 3-year survival (0.93 vs. 0.77 for lower EHDI, P<0.0001). Probability of survival was higher for patients treated at tertiary level institutions (P=0.0015). The combination of low EHDI residence province with no treatment at a tertiary institution was associated with the worst survival outcome. For both, unilateral and bilateral disease, children who died were in average diagnosed at older age. Conclusions: The incidence of retinoblastoma in Argentina is comparable to that of developed countries. Retinoblastoma is diagnosed later and survival is lower in the less developed areas of the country. © 2014 Wiley Periodicals, Inc. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_15455009_v61_n9_p1610_Moreno
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Cancer Children Retinoblastoma Survival adolescent Argentina article cancer incidence cancer survival child developed country female human major clinical study male mortality preschool child priority journal resident retinoblastoma school child socioeconomics tertiary care center cancer children retinoblastoma survival Adolescent Argentina Child Child, Preschool Cohort Studies Female Follow-Up Studies Humans Incidence Infant Infant, Newborn Male Prognosis Registries Retinal Neoplasms Retinoblastoma Survival Rate
spellingShingle	Cancer Children Retinoblastoma Survival adolescent Argentina article cancer incidence cancer survival child developed country female human major clinical study male mortality preschool child priority journal resident retinoblastoma school child socioeconomics tertiary care center cancer children retinoblastoma survival Adolescent Argentina Child Child, Preschool Cohort Studies Female Follow-Up Studies Humans Incidence Infant Infant, Newborn Male Prognosis Registries Retinal Neoplasms Retinoblastoma Survival Rate Moreno, F. Sinaki, B. Fandiño, A. Dussel, V. Orellana, L. Chantada, G. A population-based study of retinoblastoma incidence and survival in Argentine children
topic_facet	Cancer Children Retinoblastoma Survival adolescent Argentina article cancer incidence cancer survival child developed country female human major clinical study male mortality preschool child priority journal resident retinoblastoma school child socioeconomics tertiary care center cancer children retinoblastoma survival Adolescent Argentina Child Child, Preschool Cohort Studies Female Follow-Up Studies Humans Incidence Infant Infant, Newborn Male Prognosis Registries Retinal Neoplasms Retinoblastoma Survival Rate
description	Background: An increased incidence of retinoblastoma in some developing countries has been reported but no conclusive data are available from population-based studies at national level. Purpose: To report the incidence and survival of retinoblastoma in Argentina from the National Pediatric Cancer Registry (ROHA) and the influence of socio-economical indicators on outcome. Procedure: Cases reported to the ROHA (2000-2009) were analyzed. Incidence rates were calculated using National Vital Statistics and survival was estimated. The extended human development index (EHDI) was used as a socio-economical indicator. Results: With 438 patients reported, an incidence of 5.0 cases per million children 0-14 years old (95% CI 3.5-6.4) was calculated. Median age at diagnosis was significantly higher for children from provinces with lower EHDI; (24 vs. 35 months for unilateral, (P=0.003) and 9 versus 11.5 months for bilateral retinoblastoma (P=0.027). The 3-year probability of survival was 0.87 and 0.94 for unilateral and bilateral retinoblastoma, respectively. Residents in provinces with higher EHDI had a better 3-year survival (0.93 vs. 0.77 for lower EHDI, P<0.0001). Probability of survival was higher for patients treated at tertiary level institutions (P=0.0015). The combination of low EHDI residence province with no treatment at a tertiary institution was associated with the worst survival outcome. For both, unilateral and bilateral disease, children who died were in average diagnosed at older age. Conclusions: The incidence of retinoblastoma in Argentina is comparable to that of developed countries. Retinoblastoma is diagnosed later and survival is lower in the less developed areas of the country. © 2014 Wiley Periodicals, Inc.
format	JOUR
author	Moreno, F. Sinaki, B. Fandiño, A. Dussel, V. Orellana, L. Chantada, G.
author_facet	Moreno, F. Sinaki, B. Fandiño, A. Dussel, V. Orellana, L. Chantada, G.
author_sort	Moreno, F.
title	A population-based study of retinoblastoma incidence and survival in Argentine children
title_short	A population-based study of retinoblastoma incidence and survival in Argentine children
title_full	A population-based study of retinoblastoma incidence and survival in Argentine children
title_fullStr	A population-based study of retinoblastoma incidence and survival in Argentine children
title_full_unstemmed	A population-based study of retinoblastoma incidence and survival in Argentine children
title_sort	population-based study of retinoblastoma incidence and survival in argentine children
url	http://hdl.handle.net/20.500.12110/paper_15455009_v61_n9_p1610_Moreno
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A population-based study of retinoblastoma incidence and survival in Argentine children

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