Stochastic fire-diffuse-fire model with realistic cluster dynamics
Living organisms use waves that propagate through excitable media to transport information. Ca2 + waves are a paradigmatic example of this type of processes. A large hierarchy of Ca2 + signals that range from localized release events to global waves has been observed in Xenopus laevis oocytes. In th...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_15393755_v82_n3_p_Calabrese |
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todo:paper_15393755_v82_n3_p_Calabrese2023-10-03T16:22:34Z Stochastic fire-diffuse-fire model with realistic cluster dynamics Calabrese, A. Fraiman, D. Zysman, D. Ponce Dawson, S. Calcium dynamics Cluster dynamics Cluster models Discrete stochastic models Endoplasmic reticulum Excitable media Experimental observation Fire-diffuse-fire models Living organisms Reaction diffusion equations Transition regimes Xenopus laevis oocytes Biology Linear equations Stochastic systems Sugars Stochastic models Living organisms use waves that propagate through excitable media to transport information. Ca2 + waves are a paradigmatic example of this type of processes. A large hierarchy of Ca2 + signals that range from localized release events to global waves has been observed in Xenopus laevis oocytes. In these cells, Ca2 + release occurs trough inositol 1,4,5-trisphosphate receptors (IP 3 Rs) which are organized in clusters of channels located on the membrane of the endoplasmic reticulum. In this article we construct a stochastic model for a cluster of IP 3 R 's that replicates the experimental observations reported in. We then couple this phenomenological cluster model with a reaction-diffusion equation, so as to have a discrete stochastic model for calcium dynamics. The model we propose describes the transition regimes between isolated release and steadily propagating waves as the IP 3 concentration is increased. © 2010 The American Physical Society. Fil:Zysman, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ponce Dawson, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_15393755_v82_n3_p_Calabrese |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Calcium dynamics Cluster dynamics Cluster models Discrete stochastic models Endoplasmic reticulum Excitable media Experimental observation Fire-diffuse-fire models Living organisms Reaction diffusion equations Transition regimes Xenopus laevis oocytes Biology Linear equations Stochastic systems Sugars Stochastic models |
| spellingShingle |
Calcium dynamics Cluster dynamics Cluster models Discrete stochastic models Endoplasmic reticulum Excitable media Experimental observation Fire-diffuse-fire models Living organisms Reaction diffusion equations Transition regimes Xenopus laevis oocytes Biology Linear equations Stochastic systems Sugars Stochastic models Calabrese, A. Fraiman, D. Zysman, D. Ponce Dawson, S. Stochastic fire-diffuse-fire model with realistic cluster dynamics |
| topic_facet |
Calcium dynamics Cluster dynamics Cluster models Discrete stochastic models Endoplasmic reticulum Excitable media Experimental observation Fire-diffuse-fire models Living organisms Reaction diffusion equations Transition regimes Xenopus laevis oocytes Biology Linear equations Stochastic systems Sugars Stochastic models |
| description |
Living organisms use waves that propagate through excitable media to transport information. Ca2 + waves are a paradigmatic example of this type of processes. A large hierarchy of Ca2 + signals that range from localized release events to global waves has been observed in Xenopus laevis oocytes. In these cells, Ca2 + release occurs trough inositol 1,4,5-trisphosphate receptors (IP 3 Rs) which are organized in clusters of channels located on the membrane of the endoplasmic reticulum. In this article we construct a stochastic model for a cluster of IP 3 R 's that replicates the experimental observations reported in. We then couple this phenomenological cluster model with a reaction-diffusion equation, so as to have a discrete stochastic model for calcium dynamics. The model we propose describes the transition regimes between isolated release and steadily propagating waves as the IP 3 concentration is increased. © 2010 The American Physical Society. |
| format |
JOUR |
| author |
Calabrese, A. Fraiman, D. Zysman, D. Ponce Dawson, S. |
| author_facet |
Calabrese, A. Fraiman, D. Zysman, D. Ponce Dawson, S. |
| author_sort |
Calabrese, A. |
| title |
Stochastic fire-diffuse-fire model with realistic cluster dynamics |
| title_short |
Stochastic fire-diffuse-fire model with realistic cluster dynamics |
| title_full |
Stochastic fire-diffuse-fire model with realistic cluster dynamics |
| title_fullStr |
Stochastic fire-diffuse-fire model with realistic cluster dynamics |
| title_full_unstemmed |
Stochastic fire-diffuse-fire model with realistic cluster dynamics |
| title_sort |
stochastic fire-diffuse-fire model with realistic cluster dynamics |
| url |
http://hdl.handle.net/20.500.12110/paper_15393755_v82_n3_p_Calabrese |
| work_keys_str_mv |
AT calabresea stochasticfirediffusefiremodelwithrealisticclusterdynamics AT fraimand stochasticfirediffusefiremodelwithrealisticclusterdynamics AT zysmand stochasticfirediffusefiremodelwithrealisticclusterdynamics AT poncedawsons stochasticfirediffusefiremodelwithrealisticclusterdynamics |
| _version_ |
1807319737652215808 |