Monocyte-derived dendritic cells loaded with a mixture of apoptotic/ necrotic melanoma cells efficiently cross-present gp100 and MART-1 antigens to specific CD8+ T lymphocytes

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Background: In the present study, we demonstrate, in rigorous fashion, that human monocyte-derived immature dendritic cells (DCs) can efficiently cross-present tumor-associated antigens when co-cultured with a mixture of human melanoma cells rendered apoptotic/necrotic by γ irradiation (Apo-Nec cell...

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Autores principales:	von Euw, E.M., Barrio, M.M., Furman, D., Bianchini, M., Levy, E.M., Yee, C., Li, Y., Wainstok, R., Mordoh, J.
Formato:	JOUR
Materias:	B7 antigen cancer vaccine CD40 antigen CD83 antigen CD86 antigen chemokine chemokine receptor CCR7 dendritic cell vaccine dextran fluorescein isothiocyanate gamma interferon glycoprotein gp 100 HLA A antigen HLA antigen HLA antigen class 1 HLA antigen class 2 HLA antigen class 3 interleukin 10 interleukin 12 macrophage inflammatory protein 3beta melan A tumor antigen unclassified drug CCR7 protein, human epitope melanocyte protein Pmel 17 membrane protein MLANA protein, human SILV protein, human tumor protein antigen expression antigen specificity apoptosis article CD8+ T lymphocyte cell cloning cell death cell kinetics cell maturation cell migration cell surface cell vacuole coculture controlled study cross presentation cytokine release cytotoxic T lymphocyte dendritic cell electron microscopy fluorescence activated cell sorting gamma irradiation human human cell in vitro study melanoma cell monocyte phagocytosis upregulation vaccination cell differentiation cell motion cytology drug effect gamma radiation immunology melanoma necrosis pathology radiation exposure time tumor cell line ultrastructure Antigens, Neoplasm Apoptosis CD8-Positive T-Lymphocytes Cell Differentiation Cell Line, Tumor Cell Movement Chemokine CCL19 Coculture Techniques Cross-Priming Dendritic Cells Epitopes Gamma Rays gp100 Melanoma Antigen Humans Interleukin-10 Interleukin-12 MART-1 Antigen Melanoma Membrane Glycoproteins Monocytes Necrosis Neoplasm Proteins Phagocytosis Receptors, CCR7 Time Factors
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_14795876_v5_n_p_vonEuw
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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