Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions

Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillator...

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Detalles Bibliográficos
Autores principales: Uriu, K., Ares, S., Oates, A.C., Morelli, L.G.
Formato: JOUR
Materias:
animal
article
biological model
biological rhythm
cell communication
cell motion
computer simulation
human
morphogenesis
signal transduction
Animals
Biological Clocks
Cell Communication
Cell Movement
Computer Simulation
Humans
Models, Biological
Morphogenesis
Signal Transduction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_14783967_v9_n3_p_Uriu
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_14783967_v9_n3_p_Uriu
record_format dspace
spelling todo:paper_14783967_v9_n3_p_Uriu2023-10-03T16:19:26Z Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions Uriu, K. Ares, S. Oates, A.C. Morelli, L.G. animal article biological model biological rhythm cell communication cell motion computer simulation human morphogenesis signal transduction Animals Biological Clocks Cell Communication Cell Movement Computer Simulation Humans Models, Biological Morphogenesis Signal Transduction Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillators. An important assumption in these studies is that cells can immediately interact with their new neighbors after arriving at a new location. However, intercellular interactions in cellular systems may need some time to become fully established. How movement affects synchronization in this situation has not been examined. Here, we develop a coupled phase oscillator model in which we consider cell movement and the gradual recovery of intercellular coupling experienced by a cell after movement, characterized by a moving rate and a coupling recovery rate, respectively. We find (1) an optimal moving rate for synchronization and (2) a critical moving rate above which achieving synchronization is not possible. These results indicate that the extent to which movement enhances synchrony is limited by a gradual recovery of coupling. These findings suggest that the ratio of time scales of movement and signaling recovery is critical for information transfer between moving cells. © 2012 IOP Publishing Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14783967_v9_n3_p_Uriu
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic animal
article
biological model
biological rhythm
cell communication
cell motion
computer simulation
human
morphogenesis
signal transduction
Animals
Biological Clocks
Cell Communication
Cell Movement
Computer Simulation
Humans
Models, Biological
Morphogenesis
Signal Transduction
spellingShingle animal
article
biological model
biological rhythm
cell communication
cell motion
computer simulation
human
morphogenesis
signal transduction
Animals
Biological Clocks
Cell Communication
Cell Movement
Computer Simulation
Humans
Models, Biological
Morphogenesis
Signal Transduction
Uriu, K.
Ares, S.
Oates, A.C.
Morelli, L.G.
Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
topic_facet animal
article
biological model
biological rhythm
cell communication
cell motion
computer simulation
human
morphogenesis
signal transduction
Animals
Biological Clocks
Cell Communication
Cell Movement
Computer Simulation
Humans
Models, Biological
Morphogenesis
Signal Transduction
description Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillators. An important assumption in these studies is that cells can immediately interact with their new neighbors after arriving at a new location. However, intercellular interactions in cellular systems may need some time to become fully established. How movement affects synchronization in this situation has not been examined. Here, we develop a coupled phase oscillator model in which we consider cell movement and the gradual recovery of intercellular coupling experienced by a cell after movement, characterized by a moving rate and a coupling recovery rate, respectively. We find (1) an optimal moving rate for synchronization and (2) a critical moving rate above which achieving synchronization is not possible. These results indicate that the extent to which movement enhances synchrony is limited by a gradual recovery of coupling. These findings suggest that the ratio of time scales of movement and signaling recovery is critical for information transfer between moving cells. © 2012 IOP Publishing Ltd.
format JOUR
author Uriu, K.
Ares, S.
Oates, A.C.
Morelli, L.G.
author_facet Uriu, K.
Ares, S.
Oates, A.C.
Morelli, L.G.
author_sort Uriu, K.
title Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
title_short Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
title_full Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
title_fullStr Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
title_full_unstemmed Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
title_sort optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
url http://hdl.handle.net/20.500.12110/paper_14783967_v9_n3_p_Uriu
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