Impact of upstream and downstream constraints on a signaling module's ultrasensitivity

Much work has been done on the study of the biochemical mechanisms that result in ultrasensitive behavior of simple biochemical modules. However, in a living cell, such modules are embedded in a bigger network that constrains the range of inputs that the module will receive as well as the range of t...

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Autores principales: Altszyler, E., Ventura, A., Colman-Lerner, A., Chernomoretz, A.
Formato: JOUR
Materias:
dynamic range
Signaling
transfer function
ultrasensitivity
biological model
kinetics
signal transduction
Kinetics
Models, Biological
Signal Transduction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_14783967_v11_n6_p_Altszyler
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_14783967_v11_n6_p_Altszyler
record_format dspace
spelling todo:paper_14783967_v11_n6_p_Altszyler2023-10-03T16:19:24Z Impact of upstream and downstream constraints on a signaling module's ultrasensitivity Altszyler, E. Ventura, A. Colman-Lerner, A. Chernomoretz, A. dynamic range Signaling transfer function ultrasensitivity biological model kinetics signal transduction Kinetics Models, Biological Signal Transduction Much work has been done on the study of the biochemical mechanisms that result in ultrasensitive behavior of simple biochemical modules. However, in a living cell, such modules are embedded in a bigger network that constrains the range of inputs that the module will receive as well as the range of the module's outputs that network will be able to detect. Here, we studied how the effective ultrasensitivity of a modular system is affected by these restrictions. We use a simple setup to explore to what extent the dynamic range spanned by upstream and downstream components of an ultrasensitive module impact on the effective sensitivity of the system. Interestingly, we found for some ultrasensitive motifs that dynamic range limitations imposed by downstream components can produce effective sensitivities much larger than that of the original module when considered in isolation. © 2014 IOP Publishing Ltd. Fil:Ventura, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Colman-Lerner, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Chernomoretz, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14783967_v11_n6_p_Altszyler
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic dynamic range
Signaling
transfer function
ultrasensitivity
biological model
kinetics
signal transduction
Kinetics
Models, Biological
Signal Transduction
spellingShingle dynamic range
Signaling
transfer function
ultrasensitivity
biological model
kinetics
signal transduction
Kinetics
Models, Biological
Signal Transduction
Altszyler, E.
Ventura, A.
Colman-Lerner, A.
Chernomoretz, A.
Impact of upstream and downstream constraints on a signaling module's ultrasensitivity
topic_facet dynamic range
Signaling
transfer function
ultrasensitivity
biological model
kinetics
signal transduction
Kinetics
Models, Biological
Signal Transduction
description Much work has been done on the study of the biochemical mechanisms that result in ultrasensitive behavior of simple biochemical modules. However, in a living cell, such modules are embedded in a bigger network that constrains the range of inputs that the module will receive as well as the range of the module's outputs that network will be able to detect. Here, we studied how the effective ultrasensitivity of a modular system is affected by these restrictions. We use a simple setup to explore to what extent the dynamic range spanned by upstream and downstream components of an ultrasensitive module impact on the effective sensitivity of the system. Interestingly, we found for some ultrasensitive motifs that dynamic range limitations imposed by downstream components can produce effective sensitivities much larger than that of the original module when considered in isolation. © 2014 IOP Publishing Ltd.
format JOUR
author Altszyler, E.
Ventura, A.
Colman-Lerner, A.
Chernomoretz, A.
author_facet Altszyler, E.
Ventura, A.
Colman-Lerner, A.
Chernomoretz, A.
author_sort Altszyler, E.
title Impact of upstream and downstream constraints on a signaling module's ultrasensitivity
title_short Impact of upstream and downstream constraints on a signaling module's ultrasensitivity
title_full Impact of upstream and downstream constraints on a signaling module's ultrasensitivity
title_fullStr Impact of upstream and downstream constraints on a signaling module's ultrasensitivity
title_full_unstemmed Impact of upstream and downstream constraints on a signaling module's ultrasensitivity
title_sort impact of upstream and downstream constraints on a signaling module's ultrasensitivity
url http://hdl.handle.net/20.500.12110/paper_14783967_v11_n6_p_Altszyler
work_keys_str_mv AT altszylere impactofupstreamanddownstreamconstraintsonasignalingmodulesultrasensitivity
AT venturaa impactofupstreamanddownstreamconstraintsonasignalingmodulesultrasensitivity
AT colmanlernera impactofupstreamanddownstreamconstraintsonasignalingmodulesultrasensitivity
AT chernomoretza impactofupstreamanddownstreamconstraintsonasignalingmodulesultrasensitivity
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