One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction

A pseudo-five-multicomponent reaction involving an isocyanide, a primary amine, two molecules of formaldehyde and water is reported, which gives N,N′-substituted 4-imidazolidinones when trifluoroethanol is used as the solvent. The reaction proceeds with good yields and with a wide variety of amines...

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Autores principales:	Attorresi, C.I., Bonifazi, E.L., Ramírez, J.A., Gola, G.F.
Formato:	JOUR
Materias:	Amines Cyanides Ethanol Polyols Heterocycles Isocyanides Multi-component reactions One step synthesis Primary amines Reaction mechanism Reaction pathways Trifluoroethanol Chemical reactions
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_14770520_v16_n46_p8944_Attorresi
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_14770520_v16_n46_p8944_Attorresi2023-10-03T16:19:06Z One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction Attorresi, C.I. Bonifazi, E.L. Ramírez, J.A. Gola, G.F. Amines Cyanides Ethanol Polyols Heterocycles Isocyanides Multi-component reactions One step synthesis Primary amines Reaction mechanism Reaction pathways Trifluoroethanol Chemical reactions A pseudo-five-multicomponent reaction involving an isocyanide, a primary amine, two molecules of formaldehyde and water is reported, which gives N,N′-substituted 4-imidazolidinones when trifluoroethanol is used as the solvent. The reaction proceeds with good yields and with a wide variety of amines and isocyanides, providing an efficient new entry to these heterocycles. A preliminary study of the reaction mechanism suggests that trifluoroethanol, although acting as the solvent, is directly involved as a reagent in the reaction pathway. © 2018 The Royal Society of Chemistry. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14770520_v16_n46_p8944_Attorresi
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Amines Cyanides Ethanol Polyols Heterocycles Isocyanides Multi-component reactions One step synthesis Primary amines Reaction mechanism Reaction pathways Trifluoroethanol Chemical reactions
spellingShingle	Amines Cyanides Ethanol Polyols Heterocycles Isocyanides Multi-component reactions One step synthesis Primary amines Reaction mechanism Reaction pathways Trifluoroethanol Chemical reactions Attorresi, C.I. Bonifazi, E.L. Ramírez, J.A. Gola, G.F. One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
topic_facet	Amines Cyanides Ethanol Polyols Heterocycles Isocyanides Multi-component reactions One step synthesis Primary amines Reaction mechanism Reaction pathways Trifluoroethanol Chemical reactions
description	A pseudo-five-multicomponent reaction involving an isocyanide, a primary amine, two molecules of formaldehyde and water is reported, which gives N,N′-substituted 4-imidazolidinones when trifluoroethanol is used as the solvent. The reaction proceeds with good yields and with a wide variety of amines and isocyanides, providing an efficient new entry to these heterocycles. A preliminary study of the reaction mechanism suggests that trifluoroethanol, although acting as the solvent, is directly involved as a reagent in the reaction pathway. © 2018 The Royal Society of Chemistry.
format	JOUR
author	Attorresi, C.I. Bonifazi, E.L. Ramírez, J.A. Gola, G.F.
author_facet	Attorresi, C.I. Bonifazi, E.L. Ramírez, J.A. Gola, G.F.
author_sort	Attorresi, C.I.
title	One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
title_short	One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
title_full	One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
title_fullStr	One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
title_full_unstemmed	One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
title_sort	one-step synthesis of n, n′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
url	http://hdl.handle.net/20.500.12110/paper_14770520_v16_n46_p8944_Attorresi
work_keys_str_mv	AT attorresici onestepsynthesisofnnsubstituted4imidazolidinonesbyanisocyanidebasedpseudofivemulticomponentreaction AT bonifaziel onestepsynthesisofnnsubstituted4imidazolidinonesbyanisocyanidebasedpseudofivemulticomponentreaction AT ramirezja onestepsynthesisofnnsubstituted4imidazolidinonesbyanisocyanidebasedpseudofivemulticomponentreaction AT golagf onestepsynthesisofnnsubstituted4imidazolidinonesbyanisocyanidebasedpseudofivemulticomponentreaction
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One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction

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