Fluorination methods in drug discovery
Fluorination reactions of medicinal and biologically-active compounds will be discussed. Late stage fluorination strategies of medicinal targets have recently attracted considerable attention on account of the influence that a fluorine atom can impart to targets of medicinal importance, such as modu...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_14770520_v14_n36_p8398_Yerien |
| Aporte de: |
| id |
todo:paper_14770520_v14_n36_p8398_Yerien |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_14770520_v14_n36_p8398_Yerien2023-10-03T16:19:04Z Fluorination methods in drug discovery Yerien, D.E. Bonesi, S. Postigo, A. Bioactivity Biochemistry Carbon Chemical bonds Electronegativity Fluorination Halogenation Aromatic rings Biologically active compounds Drug discovery Fluorination reactions Fluorine atoms Fluorine substitution Membrane permeability Pharmaceutical industry Fluorine fluorinated hydrocarbon fluorine chemical structure chemistry drug development halogenation synthesis Drug Discovery Fluorine Halogenation Hydrocarbons, Fluorinated Molecular Structure Fluorination reactions of medicinal and biologically-active compounds will be discussed. Late stage fluorination strategies of medicinal targets have recently attracted considerable attention on account of the influence that a fluorine atom can impart to targets of medicinal importance, such as modulation of lipophilicity, electronegativity, basicity and bioavailability, the latter as a consequence of membrane permeability. Therefore, the recourse to late-stage fluorine substitution on compounds with already known and relevant biological activity can provide the pharmaceutical industry with new leads with improved medicinal properties. The fluorination strategies will take into account different fluorinating reagents, either of nucleophilic or electrophilic, and of radical nature. Diverse families of organic compounds such as (hetero)aromatic rings, and aliphatic substrates (sp3, sp2, and sp carbon atoms) will be studied in late-stage fluorination reaction strategies. © 2014 The Royal Society of Chemistry. Fil:Bonesi, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14770520_v14_n36_p8398_Yerien |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Bioactivity Biochemistry Carbon Chemical bonds Electronegativity Fluorination Halogenation Aromatic rings Biologically active compounds Drug discovery Fluorination reactions Fluorine atoms Fluorine substitution Membrane permeability Pharmaceutical industry Fluorine fluorinated hydrocarbon fluorine chemical structure chemistry drug development halogenation synthesis Drug Discovery Fluorine Halogenation Hydrocarbons, Fluorinated Molecular Structure |
| spellingShingle |
Bioactivity Biochemistry Carbon Chemical bonds Electronegativity Fluorination Halogenation Aromatic rings Biologically active compounds Drug discovery Fluorination reactions Fluorine atoms Fluorine substitution Membrane permeability Pharmaceutical industry Fluorine fluorinated hydrocarbon fluorine chemical structure chemistry drug development halogenation synthesis Drug Discovery Fluorine Halogenation Hydrocarbons, Fluorinated Molecular Structure Yerien, D.E. Bonesi, S. Postigo, A. Fluorination methods in drug discovery |
| topic_facet |
Bioactivity Biochemistry Carbon Chemical bonds Electronegativity Fluorination Halogenation Aromatic rings Biologically active compounds Drug discovery Fluorination reactions Fluorine atoms Fluorine substitution Membrane permeability Pharmaceutical industry Fluorine fluorinated hydrocarbon fluorine chemical structure chemistry drug development halogenation synthesis Drug Discovery Fluorine Halogenation Hydrocarbons, Fluorinated Molecular Structure |
| description |
Fluorination reactions of medicinal and biologically-active compounds will be discussed. Late stage fluorination strategies of medicinal targets have recently attracted considerable attention on account of the influence that a fluorine atom can impart to targets of medicinal importance, such as modulation of lipophilicity, electronegativity, basicity and bioavailability, the latter as a consequence of membrane permeability. Therefore, the recourse to late-stage fluorine substitution on compounds with already known and relevant biological activity can provide the pharmaceutical industry with new leads with improved medicinal properties. The fluorination strategies will take into account different fluorinating reagents, either of nucleophilic or electrophilic, and of radical nature. Diverse families of organic compounds such as (hetero)aromatic rings, and aliphatic substrates (sp3, sp2, and sp carbon atoms) will be studied in late-stage fluorination reaction strategies. © 2014 The Royal Society of Chemistry. |
| format |
JOUR |
| author |
Yerien, D.E. Bonesi, S. Postigo, A. |
| author_facet |
Yerien, D.E. Bonesi, S. Postigo, A. |
| author_sort |
Yerien, D.E. |
| title |
Fluorination methods in drug discovery |
| title_short |
Fluorination methods in drug discovery |
| title_full |
Fluorination methods in drug discovery |
| title_fullStr |
Fluorination methods in drug discovery |
| title_full_unstemmed |
Fluorination methods in drug discovery |
| title_sort |
fluorination methods in drug discovery |
| url |
http://hdl.handle.net/20.500.12110/paper_14770520_v14_n36_p8398_Yerien |
| work_keys_str_mv |
AT yeriende fluorinationmethodsindrugdiscovery AT bonesis fluorinationmethodsindrugdiscovery AT postigoa fluorinationmethodsindrugdiscovery |
| _version_ |
1807320342665887744 |