Involvement of leptin in the molecular physiology of the placenta

Leptin is a homeostatic regulator in the placenta where it promotes proliferation, protein synthesis and the expression of tolerogenic maternal response molecules such as HLA-G. Leptin also exerts an anti-apoptotic action in placenta controlling the expression of p53 master cell cycle regulator unde...

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Autores principales:	Schanton, M., Maymó, J.L., Pérez-Pérez, A., Sánchez-Margalet, V., Varone, C.L.
Formato:	JOUR
Materias:	cyclic AMP dependent protein kinase DNA estrogen histone leptin placental peptide hormone protein p53 transcription factor transcription factor Sp1 Article cell differentiation cell proliferation cell survival disease predisposition DNA methylation epigenetics histone acetylation homeostasis human metabolic disorder molecular biology nuclear reprogramming placenta preeclampsia pregnancy pregnancy diabetes mellitus priority journal promoter region protein expression protein function protein induction protein modification regulatory mechanism signal transduction spontaneous abortion trophoblast uterus animal cytology female metabolism physiology Animals Female Humans Leptin Placenta Pregnancy Signal Transduction
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_14701626_v155_n1_pR1_Schanton
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_14701626_v155_n1_pR1_Schanton
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spelling	todo:paper_14701626_v155_n1_pR1_Schanton2023-10-03T16:17:38Z Involvement of leptin in the molecular physiology of the placenta Schanton, M. Maymó, J.L. Pérez-Pérez, A. Sánchez-Margalet, V. Varone, C.L. cyclic AMP dependent protein kinase DNA estrogen histone leptin placental peptide hormone protein p53 transcription factor transcription factor Sp1 leptin Article cell differentiation cell proliferation cell survival disease predisposition DNA methylation epigenetics histone acetylation homeostasis human metabolic disorder molecular biology nuclear reprogramming placenta preeclampsia pregnancy pregnancy diabetes mellitus priority journal promoter region protein expression protein function protein induction protein modification regulatory mechanism signal transduction spontaneous abortion trophoblast uterus animal cytology female metabolism physiology placenta Animals Female Humans Leptin Placenta Pregnancy Signal Transduction Leptin is a homeostatic regulator in the placenta where it promotes proliferation, protein synthesis and the expression of tolerogenic maternal response molecules such as HLA-G. Leptin also exerts an anti-apoptotic action in placenta controlling the expression of p53 master cell cycle regulator under different stress conditions. On the other hand, leptin is an integrative target of different placental stimuli. The expression of leptin in placenta is regulated by hCG, insulin, steroids, hypoxia and many other growth hormones, suggesting that it might have an important endocrine function in the trophoblastic cells. The leptin expression is induced involving the cAMP/PKA or cAMP/Epac pathways which have profound actions upon human trophoblast function. The activation of PI3K and MAPK pathways also participates in the leptin expression. Estrogens play a central role during pregnancy, particularly 17β-estradiol upregulates the leptin expression in placental cells through genomic and non-genomic actions. The leptin promoter analysis reveals specific elements that are active in placental cells. The transcription factors CREB, AP1, Sp1, NFκB and the coactivator CBP are involved in the placental leptin expression. Moreover, placental leptin promoter is a target of epigenetic marks such as DNA methylation and histone acetylation that regulates not only the leptin expression in placenta during pregnancy but also determines the predisposition of acquiring adult metabolism diseases. Taken together, all these results allow a better understanding of leptin function and regulatory mechanisms of leptin expression in human placental trophoblasts, and support the importance of leptin during pregnancy and in programming adult health. © 2018 Society for Reproduction and Fertility. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14701626_v155_n1_pR1_Schanton
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	cyclic AMP dependent protein kinase DNA estrogen histone leptin placental peptide hormone protein p53 transcription factor transcription factor Sp1 leptin Article cell differentiation cell proliferation cell survival disease predisposition DNA methylation epigenetics histone acetylation homeostasis human metabolic disorder molecular biology nuclear reprogramming placenta preeclampsia pregnancy pregnancy diabetes mellitus priority journal promoter region protein expression protein function protein induction protein modification regulatory mechanism signal transduction spontaneous abortion trophoblast uterus animal cytology female metabolism physiology placenta Animals Female Humans Leptin Placenta Pregnancy Signal Transduction
spellingShingle	cyclic AMP dependent protein kinase DNA estrogen histone leptin placental peptide hormone protein p53 transcription factor transcription factor Sp1 leptin Article cell differentiation cell proliferation cell survival disease predisposition DNA methylation epigenetics histone acetylation homeostasis human metabolic disorder molecular biology nuclear reprogramming placenta preeclampsia pregnancy pregnancy diabetes mellitus priority journal promoter region protein expression protein function protein induction protein modification regulatory mechanism signal transduction spontaneous abortion trophoblast uterus animal cytology female metabolism physiology placenta Animals Female Humans Leptin Placenta Pregnancy Signal Transduction Schanton, M. Maymó, J.L. Pérez-Pérez, A. Sánchez-Margalet, V. Varone, C.L. Involvement of leptin in the molecular physiology of the placenta
topic_facet	cyclic AMP dependent protein kinase DNA estrogen histone leptin placental peptide hormone protein p53 transcription factor transcription factor Sp1 leptin Article cell differentiation cell proliferation cell survival disease predisposition DNA methylation epigenetics histone acetylation homeostasis human metabolic disorder molecular biology nuclear reprogramming placenta preeclampsia pregnancy pregnancy diabetes mellitus priority journal promoter region protein expression protein function protein induction protein modification regulatory mechanism signal transduction spontaneous abortion trophoblast uterus animal cytology female metabolism physiology placenta Animals Female Humans Leptin Placenta Pregnancy Signal Transduction
description	Leptin is a homeostatic regulator in the placenta where it promotes proliferation, protein synthesis and the expression of tolerogenic maternal response molecules such as HLA-G. Leptin also exerts an anti-apoptotic action in placenta controlling the expression of p53 master cell cycle regulator under different stress conditions. On the other hand, leptin is an integrative target of different placental stimuli. The expression of leptin in placenta is regulated by hCG, insulin, steroids, hypoxia and many other growth hormones, suggesting that it might have an important endocrine function in the trophoblastic cells. The leptin expression is induced involving the cAMP/PKA or cAMP/Epac pathways which have profound actions upon human trophoblast function. The activation of PI3K and MAPK pathways also participates in the leptin expression. Estrogens play a central role during pregnancy, particularly 17β-estradiol upregulates the leptin expression in placental cells through genomic and non-genomic actions. The leptin promoter analysis reveals specific elements that are active in placental cells. The transcription factors CREB, AP1, Sp1, NFκB and the coactivator CBP are involved in the placental leptin expression. Moreover, placental leptin promoter is a target of epigenetic marks such as DNA methylation and histone acetylation that regulates not only the leptin expression in placenta during pregnancy but also determines the predisposition of acquiring adult metabolism diseases. Taken together, all these results allow a better understanding of leptin function and regulatory mechanisms of leptin expression in human placental trophoblasts, and support the importance of leptin during pregnancy and in programming adult health. © 2018 Society for Reproduction and Fertility.
format	JOUR
author	Schanton, M. Maymó, J.L. Pérez-Pérez, A. Sánchez-Margalet, V. Varone, C.L.
author_facet	Schanton, M. Maymó, J.L. Pérez-Pérez, A. Sánchez-Margalet, V. Varone, C.L.
author_sort	Schanton, M.
title	Involvement of leptin in the molecular physiology of the placenta
title_short	Involvement of leptin in the molecular physiology of the placenta
title_full	Involvement of leptin in the molecular physiology of the placenta
title_fullStr	Involvement of leptin in the molecular physiology of the placenta
title_full_unstemmed	Involvement of leptin in the molecular physiology of the placenta
title_sort	involvement of leptin in the molecular physiology of the placenta
url	http://hdl.handle.net/20.500.12110/paper_14701626_v155_n1_pR1_Schanton
work_keys_str_mv	AT schantonm involvementofleptininthemolecularphysiologyoftheplacenta AT maymojl involvementofleptininthemolecularphysiologyoftheplacenta AT perezpereza involvementofleptininthemolecularphysiologyoftheplacenta AT sanchezmargaletv involvementofleptininthemolecularphysiologyoftheplacenta AT varonecl involvementofleptininthemolecularphysiologyoftheplacenta
_version_	1782028776437186560

Involvement of leptin in the molecular physiology of the placenta

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